Janneke W C M Mulder,D Meeike Kusters,Jeanine E Roeters van Lennep et al.
Janneke W C M Mulder et al.
Purpose of review: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of g...
Xiangqiang Shao,Robert Steiner,Amy L Peterson
Xiangqiang Shao
Purpose of review: Newborn screening is one of the most successful public health programs of the last century and offers unparalleled access to universal screening for a variety of metabolic and other disorders. Interest ...
ANGPTL3 and ApoC-III inhibitors for treating hypertriglyceridemia in context: horses for courses? [0.03%]
治疗高甘油三酯血症的ANGPTL3和ApoC-III抑制剂：适合不同患者？
Dick C Chan,Gerald F Watts
Dick C Chan
Purpose of review: Hypertriglyceridemia (HTG) is an independent and casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more effective treatments for patients with HTG. Angiop...
Familial hypercholesterolemia in children and the importance of early treatment [0.03%]
儿童家族性高胆固醇血症及早期治疗的重要性
Sibbeliene E van den Bosch,Barbara A Hutten,Willemijn E Corpeleijn et al.
Sibbeliene E van den Bosch et al.
Purpose of review: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screeni...
Yiyi Zhang,Sarah D de Ferranti,Andrew E Moran
Yiyi Zhang
Purpose of review: Despite familial hypercholesterolemia (FH) being the most common genetic cause of cardiovascular disease (CVD), genetic testing is rarely utilized in the US. This review summarizes what is known about t...
Julius L Katzmann,Ulrich Laufs
Julius L Katzmann
Purpose of review: Two large cardiovascular outcomes trials of monoclonal antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9) demonstrated that therapeutic inhibition of extracellular PCSK9 markedly r...
C-reactive protein, pharmacological treatments and diet: how to target your inflammatory burden [0.03%]
C-反应蛋白，药物治疗和饮食：如何针对你的炎症负担采取措施
Benjamin Bay,Natalie Arnold,Christoph Waldeyer
Benjamin Bay
Purpose of review: This article focuses on pharmacological agents as well as dietary changes aimed at the reduction of the inflammatory burden measured by circulating C-reactive protein concentrations. ...
Remnant cholesterol as a new lipid-lowering target to reduce cardiovascular events [0.03%]
残余胆固醇作为新的血脂降低靶点以减少心血管事件
Paolo Raggi,Maria Laura Becciu,Eliano P Navarese
Paolo Raggi
Purpose of review: Remnant cholesterol has become increasingly recognized as a direct contributor to the development of atherosclerosis and as an additional marker of cardiovascular risk. This review aims to summarize the...
Novel functions of Tribbles-homolog 1 in liver, adipocytes and atherosclerosis [0.03%]
Tribbles同源蛋白1在肝脏、脂肪细胞及动脉粥样硬化中的新功能
Ileana Hernandez-Resendiz,Ralph Burkhardt
Ileana Hernandez-Resendiz
Purpose of review: Human genetics studies have sparked great interest in the pseudokinase Tribbles homolog 1, as variant at the TRIB1 gene locus were robustly linked to several cardiometabolic traits, including plasma lip...
Shehan D Perera,Robert A Hegele
Shehan D Perera
Purpose of review: While biallelic rare APOA5 pathogenic loss-of-function (LOF) variants cause familial chylomicronemia syndrome, heterozygosity for such variants is associated with highly variable triglyceride phenotypes...