Cholesteryl ester transfer protein inhibition: a pathway to reducing risk of morbidity and promoting longevity [0.03%]
胆固醇酯转移蛋白抑制：降低疾病负担和促进长寿的途径
Michael H Davidson,Andrew Hsieh,John J P Kastelein
Michael H Davidson
Purpose of review: To review the evidence and describe the biological plausibility for the benefits of inhibiting cholesteryl ester transfer protein (CETP) on multiple organ systems through modification of lipoprotein met...
Seyed Saeed Tamehri Zadeh,Jing Pang,Dick C Chan et al.
Seyed Saeed Tamehri Zadeh et al.
Purpose of review: Familial hypercholesterolemia (FH) registries can capture unique data on FH concerning real-world practice, clinic epidemiology, natural history, cascade testing, cardiovascular consequences of late dia...
Fibroblast growth factor 21: update on genetics and molecular biology [0.03%]
成纤维细胞生长因子21：遗传学和分子生物学的最新研究进展
Daniel R Barros,Robert A Hegele
Daniel R Barros
Purpose of review: Since its discovery, most research on fibroblast growth factor 21 (FGF21) has focused on its antihyperglycemia properties. However, attention has recently shifted towards elucidating the ability of FGF2...
Distinct roles of size-defined HDL subpopulations in cardiovascular disease [0.03%]
尺寸定义的HDL亚群在心血管疾病中的不同作用
W Sean Davidson,Tomas Vaisar,Jay W Heinecke et al.
W Sean Davidson et al.
Purpose of review: Doubts about whether high-density lipoprotein-cholesterol (HDL-C) levels are causally related to atherosclerotic cardiovascular disease (CVD) risk have stimulated research on identifying HDL-related met...
Universal screening for familial hypercholesterolaemia: how can we maximise benefits and minimise potential harm for children and their families? [0.03%]
如何最大限度地提高利益并最小限度地减少儿童及其家庭进行高胆固醇血症普遍筛查的潜在危害？
Uma Ramaswami,Lorraine Priestley-Barnham,Steve E Humphries
Uma Ramaswami
Purpose of review: Universal Screening programmes to identify subjects with familial hypercholesterolaemia (FH) have been the subject of much recent interest. However, any screening programme can cause harm as well as hav...
Derek L Connolly,Vinoda Sharma,Kausik K Ray
Derek L Connolly
Purpose of review: Inclisiran is a small interfering RNA that blocks hepatocyte production of the PCSK9 (proprotein convertase subtilisin/kexin type 9) protein by specifically targeting PCKS9 mRNA in the cytoplasm. This r...
Stephen J Nicholls,Adam J Nelson,Laura F Michael
Stephen J Nicholls
Purpose of review: To review the development of oral agents to lower Lp(a) levels as an approach to reducing cardiovascular risk, with a focus on recent advances in the field. ...
Effectiveness of cascade screening for elevated lipoprotein(a), an underdiagnosed family disorder [0.03%]
高脂蛋白(a)筛查的有效性：一种被忽视的家族性疾病
Maxim E Annink,Emma S Janssen,Laurens F Reeskamp
Maxim E Annink
Purpose of review: Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent, genetic risk factor for cardiovascular disease. Though crucial for adequate risk assessment, detection of individuals at increased risk becau...
The emerging role of fat-inducing transcript 2 in endoplasmic reticulum proteostasis and lipoprotein biogenesis [0.03%]
脂肪诱导转录本2在内质网蛋白质稳态和脂蛋白生物发生中的作用不容忽视
Jeffrey L Brodsky,Anuradha Iyer,Konstantinos I Fortounas et al.
Jeffrey L Brodsky et al.
Purpose of review: This review examines the evolving role of the fat-inducing transcript 2 (FIT2) protein in lipid droplet (LD) biology and its broader implications in cellular physiology and disease. With recent advancem...