Heterozygosity for pathogenic variants in familial chylomicronemia syndrome genes: from carrier state to complex trait [0.03%]
载有家族性高乳糜微粒血症综合征基因致病突变杂合子：从携带者表型到复杂性状
Robert A Hegele
Robert A Hegele
Purpose of review: Biallelic loss-of-function (LOF) variants in any of five canonical genes - LPL, GPIHBP1, APOA5, APOC2, and LMF1 - cause familial chylomicronemia syndrome (FCS), a rare and severe Mendelian disorder. Het...
Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis [0.03%]
中东和北非地区的早发动脉粥样硬化性心血管疾病：经济损失、治疗障碍及日益严重的医疗危机政策建议
Radwa Ahmed Batran,Sara Tahoun,Amira Othman et al.
Radwa Ahmed Batran et al.
Purpose of the review: Premature atherosclerotic cardiovascular disease (ASCVD) is increasingly recognized as a major public health challenge in the Middle East and North Africa (MENA) region, where cardiovascular events ...
The role of metabolic profiling and dietary intervention in the early diagnosis and prevention of atherosclerosis [0.03%]
代谢谱型和饮食干预在动脉粥样硬化早期诊断和预防中的作用
Ali Khattib,Manar Shmet,Rasha Ashkar et al.
Ali Khattib et al.
Purpose of review: Atherosclerotic cardiovascular disease (ACVD) causes more than 17 million deaths annually, and traditional risk scores capture only part of individual risk. Metabolomic and lipidomic profiling has emerg...
A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients? [0.03%]
Janus激酶抑制对炎症性肠病患者血浆LDL胆固醇和主要不良心血管事件的利弊分析：两者不可兼得？
Katherine Muñoz Ayala,Eleonora A M Festen,Marit Westerterp
Katherine Muñoz Ayala
Purpose of review: Janus kinase (JAK) inhibitors have emerged as potent anti-inflammatory drugs and are prescribed in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). However, cardiovascular safety concerns...
Inflammation and atherosclerotic cardiovascular disease: where do we go from here? [0.03%]
炎症与动脉粥样硬化性心血管病：路在何方？
Ori Waksman,Ron Waksman
Ori Waksman
Purpose of review: Low-grade systemic inflammation, as determined by high-sensitivity C-reactive protein (hsCRP), plays a significant role in the progression and development of atherosclerotic cardiovascular disease (ASCV...
HDL and ASCVD: is high HDL-C protective, harmful, or simply misleading? [0.03%]
高密度脂蛋白胆固醇与动脉粥样硬化性心血管疾病：高高密度脂蛋白胆固醇具有保护作用、有害还是仅仅具有误导作用？
Paolo Parini,Matteo Pedrelli
Paolo Parini
Purpose of review: This review examines whether high high-density lipoprotein cholesterol (HDL-C) is protective, harmful, or simply misleading in relation to atherosclerotic cardiovascular disease (ASCVD), with emphasis o...
Miguel Nassif Junior,Renata Turrini Jacob Fazoli,Giuliano Generoso
Miguel Nassif Junior
Purpose of review: Advances in the management of lipid disorders have expanded therapeutic options for hypercholesterolemia and beyond. We review the current advances in RNA interference (RNAi) therapies as small interfer...