Macrophage cannibalism: efferocytosis in atherosclerosis [0.03%]
巨噬细胞食胞作用在动脉粥样硬化中的作用机制研究-Efferocytosis in Atherosclerosis
Amy A Baxter,Ivan K H Poon,Denuja Karunakaran
Amy A Baxter
Purpose of review: This review explores the evolving understanding of efferocytosis - the clearance of dead or dying cells by phagocytes - in the context of atherosclerosis. It highlights recent discovers in cell death mo...
Timo E Strandberg
Timo E Strandberg
Purpose of review: In 1994, the 4S trial was revolutionary by showing that cholesterol lowering with simvastatin reduced, not only atherosclerotic vascular disease (ASCVD) events, but also all-cause mortality as compared ...
Gilbert R Thompson,Shahenaz Walji,Jaimini Cegla
Gilbert R Thompson
Purpose of review: The review focusses on the role of liver transplantation, and rarely combined liver and heart transplantation, in the current management of homozygous familial hypercholesterolaemia (HoFH). ...
The complex pro-atherosclerotic role of lipoprotein(a): a multiplicity of cellular targets [0.03%]
脂蛋白(a)的复杂促动脉粥样硬化作用：多细胞靶点
Julia M Assini,Michael B Boffa,Marlys L Koschinsky
Julia M Assini
Purpose of review: Elevated plasma lipoprotein(a) (Lp(a)) is a causal and independent risk factor for atherosclerotic cardiovascular disease; therefore, understanding the fundamental mechanisms underlying Lp(a)-mediated p...
SPRINGing off the lock: the role of SPRING in S1P activity and SREBP-regulated lipid metabolism [0.03%]
去锁定的SPRING：SPRING在S1P活性和SREBP调节的脂质代谢中的作用
Ilaria Micallo,Ashley V Bullington,Daniel L Kober et al.
Ilaria Micallo et al.
Purpose of review: Lipid metabolism and de-novo lipogenesis (DNL) is broadly controlled by the SREBP transcription factors. These transcription factors are matured from membrane-anchored precursor proteins by the proteoly...
Cycling of metabolic states and metabolites as drivers of atherosclerosis [0.03%]
代谢状态和代谢物的循环作为动脉粥样硬化驱动因素的作用
Franziska Krautter,Edward A Fisher
Franziska Krautter
Purpose of review: Cardiovascular diseases (CVDs) are a leading cause of death worldwide. While it is well known that obesity, dyslipidemia and diabetes are major risk factors of CVD, observational clinical studies have s...
Therapeutic lowering of lipoprotein(a): implications for improving outcomes in patients with peripheral arterial disease [0.03%]
脂蛋白(a)的治疗性降低：对改善外周动脉疾病患者预后的意义
Stephen J Nicholls
Stephen J Nicholls
Purpose of review: To identify the opportunity of targeting patients with elevated lipoprotein(a) [Lp(a)] in patients with peripheral arterial disease (PAD). ...