A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients? [0.03%]
Janus激酶抑制对炎症性肠病患者血浆LDL胆固醇和主要不良心血管事件的利弊分析：两者不可兼得？
Katherine Muñoz Ayala,Eleonora A M Festen,Marit Westerterp
Katherine Muñoz Ayala
Purpose of review: Janus kinase (JAK) inhibitors have emerged as potent anti-inflammatory drugs and are prescribed in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). However, cardiovascular safety concerns...
Inflammation and atherosclerotic cardiovascular disease: where do we go from here? [0.03%]
炎症与动脉粥样硬化性心血管病：路在何方？
Ori Waksman,Ron Waksman
Ori Waksman
Purpose of review: Low-grade systemic inflammation, as determined by high-sensitivity C-reactive protein (hsCRP), plays a significant role in the progression and development of atherosclerotic cardiovascular disease (ASCV...
HDL and ASCVD: is high HDL-C protective, harmful, or simply misleading? [0.03%]
高密度脂蛋白胆固醇与动脉粥样硬化性心血管疾病：高高密度脂蛋白胆固醇具有保护作用、有害还是仅仅具有误导作用？
Paolo Parini,Matteo Pedrelli
Paolo Parini
Purpose of review: This review examines whether high high-density lipoprotein cholesterol (HDL-C) is protective, harmful, or simply misleading in relation to atherosclerotic cardiovascular disease (ASCVD), with emphasis o...
Miguel Nassif Junior,Renata Turrini Jacob Fazoli,Giuliano Generoso
Miguel Nassif Junior
Purpose of review: Advances in the management of lipid disorders have expanded therapeutic options for hypercholesterolemia and beyond. We review the current advances in RNA interference (RNAi) therapies as small interfer...
Beyond cellular distress: reframing GDF15 as a lipid-sensitive metabolic signal [0.03%]
超越细胞应激：将GDF15重新定位为脂质敏感性代谢信号
Dongdong Wang,Logan K Townsend,Gregory R Steinberg
Dongdong Wang
Purpose of review: Growth differentiation factor-15 (GDF15) is widely described as a hormone that conveys somatic distress to the brain, yet this framework does not explain why GDF15 is elevated in many common metabolic s...
Polygenic risk scores in familial hypercholesterolemia. Do they have a role? [0.03%]
家族性高胆固醇血症中的多基因风险评分有其作用吗？
Martine Paquette,Simon-Pierre Guay,Alexis Baass
Martine Paquette
Purpose of review: Risk assessment in patients with familial hypercholesterolemia (FH) remains an important clinical challenge. The polygenic susceptibility for plasma lipoprotein traits or coronary artery disease (CAD) c...
Ali K Jaafar,Steeve Bourane,Gilles C Lambert et al.
Ali K Jaafar et al.
Purpose of review: Elevated concentrations of both low-density lipoprotein (LDL)-cholesterol and lipoprotein(a) [Lp(a)] is probably the most detrimental lipid profile in terms of cardiovascular health. Our primary objecti...
Emerging regulators of endothelial lipid metabolism in atherosclerosis [0.03%]
动脉粥样硬化中新兴的内皮细胞脂质代谢调节因子
Jason S Irei,Kai Hirayama,William A Boisvert
Jason S Irei
Purpose of review: Although therapies for hyperlipidemia and hypertension have been shown to be highly effective, they have not sufficiently mitigated overall cardiovascular disease risk. Endothelial cells (ECs) are an in...