Miguel Nassif Junior,Renata Turrini Jacob Fazoli,Giuliano Generoso
Miguel Nassif Junior
Purpose of review: Advances in the management of lipid disorders have expanded therapeutic options for hypercholesterolemia and beyond. We review the current advances in RNA interference (RNAi) therapies as small interfer...
Beyond cellular distress: reframing GDF15 as a lipid-sensitive metabolic signal [0.03%]
超越细胞应激：将GDF15重新定位为脂质敏感性代谢信号
Dongdong Wang,Logan K Townsend,Gregory R Steinberg
Dongdong Wang
Purpose of review: Growth differentiation factor-15 (GDF15) is widely described as a hormone that conveys somatic distress to the brain, yet this framework does not explain why GDF15 is elevated in many common metabolic s...
Polygenic risk scores in familial hypercholesterolemia. Do they have a role? [0.03%]
家族性高胆固醇血症中的多基因风险评分有其作用吗？
Martine Paquette,Simon-Pierre Guay,Alexis Baass
Martine Paquette
Purpose of review: Risk assessment in patients with familial hypercholesterolemia (FH) remains an important clinical challenge. The polygenic susceptibility for plasma lipoprotein traits or coronary artery disease (CAD) c...
Ali K Jaafar,Steeve Bourane,Gilles C Lambert et al.
Ali K Jaafar et al.
Purpose of review: Elevated concentrations of both low-density lipoprotein (LDL)-cholesterol and lipoprotein(a) [Lp(a)] is probably the most detrimental lipid profile in terms of cardiovascular health. Our primary objecti...
Emerging regulators of endothelial lipid metabolism in atherosclerosis [0.03%]
动脉粥样硬化中新兴的内皮细胞脂质代谢调节因子
Jason S Irei,Kai Hirayama,William A Boisvert
Jason S Irei
Purpose of review: Although therapies for hyperlipidemia and hypertension have been shown to be highly effective, they have not sufficiently mitigated overall cardiovascular disease risk. Endothelial cells (ECs) are an in...
Tomas Freiberger
Tomas Freiberger
Purpose of review: Familial hypercholesterolemia is a monogenic Mendelian disorder characterized by elevated LDL cholesterol and premature atherosclerotic cardiovascular disease. It is caused by pathogenic variants in LDL...
Recent advances in understanding the spectrum of genetic determinants of lipoprotein(a) levels [0.03%]
近期关于调控Lp(a)水平的遗传决定因子研究进展
Stefan Coassin
Stefan Coassin
Purpose of review: Our understanding of the genetic regulation of lipoprotein(a) [Lp(a)] is hindered by the complex structure of the LPA gene, limited non-European datasets and its elusive cellular receptor(s). This revie...
Impact of mRNA and protein isoforms in lipoprotein metabolism and how to modulate them [0.03%]
脂蛋白代谢中的mRNA和蛋白质异构体的影响及其调节方法
Kelly M Martinovich,Jessica M Cale,May T Aung-Htut
Kelly M Martinovich
Purpose of review: More than 95% of human genes undergo alternative pre-mRNA processing based on cell type, developmental stages, and environmental stimuli, among other factors. Not all alternatively spliced mRNAs are tra...