Pancreatic and cardiometabolic complications of severe hypertriglyceridaemia [0.03%]
严重高甘油三酯血症的胰腺和心血管代谢并发症
Bilal Bashir,Maryam Ferdousi,Paul Durrington et al.
Bilal Bashir et al.
Purpose of review: This review endeavours to explore the aetiopathogenesis and impact of severe hypertriglyceridemia (SHTG) and chylomicronaemia on cardiovascular, and pancreatic complications and summarizes the novel pha...
Familial hypercholesterolemia-Plus: is the metabolic syndrome changing the clinical picture of familial hypercholesterolemia? [0.03%]
代谢综合征会改变家族性高胆固醇血症的临床表现吗？
Liam R Brunham
Liam R Brunham
Purpose of review: The purpose of this review article was to describe recent advances in our knowledge about how diabetes and metabolic syndrome are changing the face of familial hypercholesterolemia. ...
Fernando Civeira,César Martín,Ana Cenarro
Fernando Civeira
Purpose of review: Autosomal dominant hypercholesterolemia is a common cause of cardiovascular disease. In addition to the classic genes that cause hypercholesterolemia, LDLR, APOB and PCSK9 , a new locus has emerged as a...
Proprotein convertase subtilisin/kexin type 9-inhibition across different patient populations [0.03%]
不同患者群体中的丝氨酸蛋白酶PCSK9抑制作用
Paulina Elena Stürzebecher,Ulrich Laufs
Paulina Elena Stürzebecher
Purpose of review: Monoclonal antibodies (mAb) targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have been established in cardiovascular risk prevention. The purpose of this review is to summarize the effect...
How safe are proprotein convertase subtilisinekexin type 9 inhibitors in diabetes? [0.03%]
蛋白酶素转换子9抑制剂在糖尿病患者中的安全性如何？
Tian Chen,Naifeng Liu
Tian Chen
Purpose of review: To examine the safety of proprotein convertase subtilisinekexin type 9 (PCSK9) inhibitors in patients with diabetes, specifically focusing on their impact on glucose metabolism. ...
Altered lipid metabolism and the development of metabolic-associated fatty liver disease [0.03%]
脂质代谢的改变与代谢相关性脂肪肝疾病的发展
Christy Foster,Charles A Gagnon,Ambika P Ashraf
Christy Foster
Purpose of review: An increasing amount of research has underscored the significant role of lipoproteins in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). This comprehensive review examines the intr...
Basic and translational evidence supporting the role of TM6SF2 in VLDL metabolism [0.03%]
支持TM6SF2在VLDL代谢中发挥作用的基本和转化证据
Jing Liu,Henry N Ginsberg,Gissette Reyes-Soffer
Jing Liu
Purpose of review: Transmembrane 6 superfamily member 2 ( TM6SF2 ) gene was identified through exome-wide studies in 2014. A genetic variant from glutamic acid to lysine substitution at amino acid position 167 (NM_0010015...
G protein-coupled receptor 146: new insights from genetics and model systems [0.03%]
遗传学和模型系统对G蛋白偶联受体146的新见解
Umesh Tharehalli,Antoine Rimbert
Umesh Tharehalli
Purpose of review: Atherosclerotic cardiovascular diseases continue to be a significant global cause of death. Despite the availability of efficient treatments, there is an ongoing need for innovative strategies to lower ...
Ainara G Cabodevilla,Ni Son,Ira J Goldberg
Ainara G Cabodevilla
Purpose of review: Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotyp...