Inflammation in atherosclerosis: a Big Idea that has underperformed so far [0.03%]
动脉粥样硬化炎症研究：一个未达预期的重大观点
Kevin Jon Williams
Kevin Jon Williams
Purpose of review: For many years, inflammation has been a major concept in basic research on atherosclerosis and in the development of potential diagnostic tools and treatments. The purpose of this review is to assess th...
The potential of circulating nonesterified fatty acids and sphingolipids in the biological understanding of cognitive decline and dementia [0.03%]
循环未酯化脂肪酸和鞘脂在认知衰退和痴呆生物学研究中的潜在作用
Kristine F Moseholm,Josefine T Meineche,Majken K Jensen
Kristine F Moseholm
Purpose of review: Cognitive decline and late-onset dementia pose significant challenges in aging societies, and many dementia cases could be prevented or delayed through modification of associated risk factors, many of w...
Javier Hernando-Redondo,Olga Castañer Niño,Montse Fitó
Javier Hernando-Redondo
Purpose of review: Despite reductions in low-density lipoprotein (LDL) cholesterol (LDLc), residual cardiovascular risk remains due to factors beyond lipoprotein levels, such as LDL particle count, size, electronegativity...
Preeclampsia and fetal growth restriction: does novel proteomics reveal immunological possible candidate biomarkers? [0.03%]
新型蛋白质组学技术能否揭示免疫相关子痫前期和胎儿生长受限的生物标志物?
Marie Winther,Morten Hanefeld Dziegiel,Steffen Ullitz Thorsen
Marie Winther
Purpose of review: The aim of this review is to explore a possible link between immunological candidate proteins, identified through modern proteomic techniques, and preeclampsia (PE) and fetal growth restriction (FGR). ...
Jacqueline S Dron,Pradeep Natarajan,Gina M Peloso
Jacqueline S Dron
Purpose of review: This review highlights contributions of the Global Lipids Genetics Consortium (GLGC) in advancing the understanding of the genetic etiology of blood lipid traits, including total cholesterol, LDL choles...
Implementation science and genetic testing for familial hypercholesterolemia [0.03%]
基因检测在家族性高胆固醇血症的实施科学中的应用
Karen Birkenhead,David Sullivan,Gerald F Watts et al.
Karen Birkenhead et al.
Purpose of review: Familial hypercholesterolemia is a treatable genetic disorder of cholesterol metabolism. Genetic testing is the most specific method for diagnosing familial hypercholesterolemia, but it remains underuti...
Recent advances in applying metabolomics to uncover dietary impact on cardiometabolic health [0.03%]
代谢组学在揭示饮食对心血管代偿健康影响方面的最新进展
Naixin Zhang,Bjørn Lundbergh,Marta Guasch-Ferré
Naixin Zhang
Purpose of review: Cardiometabolic diseases are a major global health concern, with diet playing a crucial role in their prevention and management. Recent advancements in the identification of metabolic signatures related...
Martine Paquette,Simon-Pierre Guay,Alexis Baass
Martine Paquette
Purpose of review: In recent years, studies have shed light on the concept of risk heterogeneity among patients with severe hypertriglyceridemia (HTG). Several clinical risk factors for acute pancreatitis have been identi...
Lourdes Chávez-Alfaro,Víctor Silveira-Sanguino,Carmen Piernas
Lourdes Chávez-Alfaro
Purpose of review: Cardiometabolic diseases (CMDs) increasingly contribute to the cumulative burden of morbidity and mortality worldwide. Here, we reviewed intervention studies using a randomized controlled trial (RCT) de...