Isaiah Little,Stephanie Bersie,Elizabeth F Redente et al.
Isaiah Little et al.
Purpose of review: As the primary guardians at the air-surface interface, the functional profile of alveolar macrophages (AM) is wide-ranging from establishment of the alveolar niche, homeostatic maintenance of surfactant...
Tatsuya Sato,Marenao Tanaka,Masato Furuhashi
Tatsuya Sato
Purpose of review: Small dense low-density lipoprotein cholesterol (sdLDL-C) is recognized for its strong atherosclerogenic potential. However, its direct measurement remains impractical in clinical settings due to its hi...
Genetic influences on macrophage function and lipid uptake in atherosclerosis [0.03%]
遗传因素对动脉粥样硬化中巨噬细胞功能和脂质摄取的影响
Chris A O&#x;Callaghan,Jiahao Jiang
Chris A O&#x;Callaghan
Purpose of review: Macrophages can accumulate lipid droplets in their cytoplasm resulting in the foamy appearance seen in various diseases, especially atherosclerosis. This review assesses new insights from single cell an...
The intracellular chylomicron highway: novel insights into chylomicron biosynthesis, trafficking, and secretion [0.03%]
细胞内的乳糜微粒通路：关于乳糜微粒生物合成、运输和分泌的新见解
Ankia Visser,M Mahmood Hussain,Jan Albert Kuivenhoven
Ankia Visser
Purpose of review: Chylomicron biosynthesis plays a vital role in supplying essential lipids and lipid soluble vitamins to peripheral tissues for various functions. Despite this, the intracellular synthesis, trafficking, ...
The need for national and international registries of patients with elevated lipoprotein(a) [0.03%]
需要建立载脂蛋白(a)水平升高患者的国家和国际登记系统
Adam I Kramer,Iulia Iatan,Liam R Brunham
Adam I Kramer
Purpose of review: Elevated lipoprotein(a) [Lp(a)] is a genetically determined independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Current guidelines recommend universal testing of Lp(a) once in an...
Therapeutic advances in the Lp(a) battle: what do we know and what are the most awaited novelties in the field ? [0.03%]
Lp(a)战斗中的治疗进展：我们知道了什么，该领域最期待的创新是什么？
Marc Jean-Gilles,Baris Gencer
Marc Jean-Gilles
Purpose of review: To review the latest advances in lipoprotein(a) [Lp(a)] treatment, focusing on the impact of currently available lipid-lowering therapies and highlighting the highly anticipated and most developed RNA-b...
Fahad Alnouri,Frederick J Raal
Fahad Alnouri
Purpose of review: Individuals with familial hypercholesterolemia (FH), particularly those with homozygous FH (HoFH) who have markedly elevated LDL-cholesterol (LDL-C) levels from birth, present with unique complications ...
Leveraging drug-target Mendelian randomization for tailored lipoprotein-lipid lowering [0.03%]
利用药物靶点孟德尔随机化进行针对性的脂蛋白血脂降低治疗
Eloi Gagnon,Benoit J Arsenault
Eloi Gagnon
Purpose of review: The study of naturally occurring genetic variation in human populations has laid the foundation for proprotein converts subtilisin/kexin type 9 inhibitors, and more recently new classes of lipid-lowerin...
Yash Prakash,Deepak L Bhatt,Waqas A Malick
Yash Prakash
Purpose of review: Hypertriglyceridemia (HTG), which arises from defects in triglyceride-rich lipoprotein (TRL) metabolism, is associated with increased morbidity and mortality from pancreatitis and atherosclerotic cardio...
Navigating variants of uncertain significance in genetic dyslipidemia: how to assess and counsel patients [0.03%]
在遗传性血脂异常中处理不确定意义的变异：如何评估和指导患者
Hannah E Ison,Benjamin Helm,Gabriel Kringlen et al.
Hannah E Ison et al.
Purpose of review: Genetic testing has become an integral component of clinical care when an inherited condition is suspected. However, the interpretation of variants identified with this testing can be nuanced. Variants ...