Lipoprotein(a) and peripheral artery disease: contemporary evidence and therapeutic advances [0.03%]
脂蛋白(a)与外周动脉疾病：最新证据和治疗进展
Shivshankar Thanigaimani,Maarisha Kumar,Jonathan Golledge
Shivshankar Thanigaimani
Purpose of review: Peripheral artery disease (PAD) is a major cause of global health burden, including amputation and impaired quality of life. This review examines the evidence implicating lipoprotein(a) [Lp(a)] in PAD, ...
Are Lipoprotein(a) levels decreased in insulin resistance and type 2 diabetes? [0.03%]
脂代谢异常：胰岛素抵抗和2型糖尿病患者的Lp(a)水平降低？
Pablo Corral,María Gabriela Matta,Laura Schreier
Pablo Corral
Purpose of review: Lipoprotein(a) [Lp(a)] is a significant player in cardiovascular disease (CVD) and type 2 diabetes (T2D). While Lp(a) contributes to residual cardiovascular risk in T2D, lower levels paradoxically incre...
The lipid-heart hypothesis from the Seven Countries Study of Cardiovascular Diseases [0.03%]
七国研究中的脂类-心脏病假说
Alessandro Menotti,Paolo Emilio Puddu
Alessandro Menotti
Purpose of review: To summarize and comment recent analyses from the Seven Countries Study of Cardiovascular Diseases (SCS) on the role of Atherogenicity (ATI) and Thrombogenicity (THI) indexes (created by combining sever...
Anders B Wulff,Børge G Nordestgaard
Anders B Wulff
Purpose of review: Remnant cholesterol is receiving increasing attention as a target to reduce residual atherosclerotic cardiovascular disease (ASCVD) risk in individuals already treated with statins. New therapeutic opti...
Impact of Achilles tendon on diagnosis and phenotypes of familial hypercholesterolemia [0.03%]
跟腱病变对家族性高胆固醇血症诊断和表型的影响
Hayato Tada,Atsushi Nohara,Masa-Aki Kawashiri et al.
Hayato Tada et al.
Purpose of review: Achilles tendon thickness is one of the most specific physical findings of familial hypercholesterolemia (FH), and thus it is used as one of the clinical diagnostic criteria. However, the objective asse...
Robert A Hegele
Robert A Hegele
Purpose of review: Genetic testing of patients with severe hypertriglyceridemia often identifies a single heterozygous pathogenic variant in the LPL gene. The complex and variable phenotype associated with this genotype i...
Safety and effectiveness of proprotein convertase subtilisin/kexin type 9 inhibition: an updated review [0.03%]
PCSK9抑制剂的安全性和有效性：综述更新版
Konstantinos Pamporis,Paschalis Karakasis,Dimitrios Tsiachris
Konstantinos Pamporis
Purpose of review: To summarize the recent literature on the effectiveness and safety of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) in reducing low-density lipoprotein cholesterol (LDL-C) and mitiga...