Gilbert R Thompson,Shahenaz Walji,Jaimini Cegla
Gilbert R Thompson
Purpose of review: The review focusses on the role of liver transplantation, and rarely combined liver and heart transplantation, in the current management of homozygous familial hypercholesterolaemia (HoFH). ...
The complex pro-atherosclerotic role of lipoprotein(a): a multiplicity of cellular targets [0.03%]
脂蛋白(a)的复杂促动脉粥样硬化作用：多细胞靶点
Julia M Assini,Michael B Boffa,Marlys L Koschinsky
Julia M Assini
Purpose of review: Elevated plasma lipoprotein(a) (Lp(a)) is a causal and independent risk factor for atherosclerotic cardiovascular disease; therefore, understanding the fundamental mechanisms underlying Lp(a)-mediated p...
SPRINGing off the lock: the role of SPRING in S1P activity and SREBP-regulated lipid metabolism [0.03%]
去锁定的SPRING：SPRING在S1P活性和SREBP调节的脂质代谢中的作用
Ilaria Micallo,Ashley V Bullington,Daniel L Kober et al.
Ilaria Micallo et al.
Purpose of review: Lipid metabolism and de-novo lipogenesis (DNL) is broadly controlled by the SREBP transcription factors. These transcription factors are matured from membrane-anchored precursor proteins by the proteoly...
Cycling of metabolic states and metabolites as drivers of atherosclerosis [0.03%]
代谢状态和代谢物的循环作为动脉粥样硬化驱动因素的作用
Franziska Krautter,Edward A Fisher
Franziska Krautter
Purpose of review: Cardiovascular diseases (CVDs) are a leading cause of death worldwide. While it is well known that obesity, dyslipidemia and diabetes are major risk factors of CVD, observational clinical studies have s...
Therapeutic lowering of lipoprotein(a): implications for improving outcomes in patients with peripheral arterial disease [0.03%]
脂蛋白(a)的治疗性降低：对改善外周动脉疾病患者预后的意义
Stephen J Nicholls
Stephen J Nicholls
Purpose of review: To identify the opportunity of targeting patients with elevated lipoprotein(a) [Lp(a)] in patients with peripheral arterial disease (PAD). ...
Samuel C Delk,Srinivasa T Reddy,Alan M Fogelman
Samuel C Delk
Purpose of review: A review of recent publications demonstrating the important role of the intestine in the pathogenesis of cardiovascular disease. Recent...
Beyond cholesterol: linking the conformation of apolipoprotein B to atherogenesis [0.03%]
胆固醇之外：载脂蛋白B构象与动脉粥样硬化之间的联系
Katariina Öörni,Martina B Lorey
Katariina Öörni
Purpose of review: This review integrates recent structural and biochemical insights into apolipoprotein B (apoB) containing lipoproteins to highlight how factors beyond cholesterol levels contribute to atherosclerosis. ...
Peripheral arterial disease associated with elevated lipoprotein(a): a review of the evidence and treatment approaches [0.03%]
脂蛋白(a)升高的外周动脉疾病：证据和治疗综述
Harpreet S Bhatia,Sonar Dalal,Elsie Ross
Harpreet S Bhatia
Purpose of review: Peripheral arterial disease (PAD) is an atherosclerotic and thrombotic disease associated with substantial morbidity and mortality. Although risk factors for PAD are mostly modifiable, prognosis remains...