Annie Haase,Anne C Goldberg
Annie Haase
Purpose of review: Familial hypercholesterolemia is an underdiagnosed autosomal codominant genetic condition associated with significantly increased risk of early cardiovascular disease when untreated. Early diagnosis and...
Heme and haemoglobin direct macrophage Mhem phenotype and counter foam cell formation in areas of intraplaque haemorrhage [0.03%]
血红素和血红蛋白可直接诱导巨噬细胞生成Mheme表型并对抗泡沫细胞形成以修复动脉粥样硬化斑块内出血区域损伤
Joseph J Boyle
Joseph J Boyle
Purpose of review: Several studies have recently shown that haemoglobin drives a novel macrophage subset that is protected from foam cell formation. Recen...
LOX-1: a multiligand receptor at the crossroads of response to danger signals [0.03%]
LOX-1：一个位于危险信号反应交叉路口的多配体受体
Tatsuya Sawamura,Akemi Kakino,Yoshiko Fujita
Tatsuya Sawamura
Purpose of review: LOX-1 is a multiligand receptor implicated in endothelial dysfunction and atherosclerosis, although it was originally identified as an oxidized LDL receptor. In this review, the roles of various LOX-1 l...
Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease [0.03%]
溶血磷脂酰基转移酶：从发现到疾病
Anil K Agarwal
Anil K Agarwal
Purpose of review: Over the past several years, many more isoforms for the same enzymes, specifically for 1-acylglycerol-3-phosphate O-acyltransferases (AGPATs), have been cloned and studied. In this review, we summarize ...
HDL functionality [0.03%]
HDL功能
Handrean Soran,Salam Hama,Rahul Yadav et al.
Handrean Soran et al.
Purpose of review: HDL cholesterol concentration is inversely correlated with cardiovascular disease and has a wide range of functions involved in many systems. The purpose of this review is to summarize HDL functionality...
Richard Bulbulia,Jane Armitage
Richard Bulbulia
Purpose of review: Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians...
Daniel Gaudet,Julie Méthot,John Kastelein
Daniel Gaudet
Purpose of review: The present review summarizes the clinical development of adeno-associated viral vector (AAV)1-lipoprotein lipase (LPL)S447X gene therapy (alipogene tiparvovec) for lipoprotein lipase deficiency. Lipopr...
Søren Nielsen,Fredrik Karpe
Søren Nielsen
Purpose of review: Plasma free fatty acids (FFA) are major substrates for hepatic VLDL-triglycerides (VLDL-TG) production. In addition, it is a common belief that VLDL-TG production is a substrate driven process primarily...
The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia [0.03%]
通路选择性胰岛素抵抗和反应在糖尿病脂蛋白异常中的作用
Xiangdong Wu,Keyang Chen,Kevin Jon Williams
Xiangdong Wu
Purpose of review: Type 2 diabetes mellitus (T2DM) and related syndromes exhibit a deadly triad of dyslipoproteinemia, which leads to atherosclerosis, hyperglycemia, which causes microvascular disease, and hypertension. T...
Roberta Ara,Hasan Basarir,Sue Elizabeth Ward
Roberta Ara
Purpose of review: Policy decision-making in cardiovascular disease is increasingly informed by the results generated from decision-analytic models (DAMs). The methodological approaches and assumptions used in these DAMs ...