Proprotein convertase subtilisin/kexin type 9-inhibition across different patient populations [0.03%]
不同患者群体中的丝氨酸蛋白酶PCSK9抑制作用
Paulina Elena Stürzebecher,Ulrich Laufs
Paulina Elena Stürzebecher
Purpose of review: Monoclonal antibodies (mAb) targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have been established in cardiovascular risk prevention. The purpose of this review is to summarize the effect...
How safe are proprotein convertase subtilisinekexin type 9 inhibitors in diabetes? [0.03%]
蛋白酶素转换子9抑制剂在糖尿病患者中的安全性如何？
Tian Chen,Naifeng Liu
Tian Chen
Purpose of review: To examine the safety of proprotein convertase subtilisinekexin type 9 (PCSK9) inhibitors in patients with diabetes, specifically focusing on their impact on glucose metabolism. ...
Altered lipid metabolism and the development of metabolic-associated fatty liver disease [0.03%]
脂质代谢的改变与代谢相关性脂肪肝疾病的发展
Christy Foster,Charles A Gagnon,Ambika P Ashraf
Christy Foster
Purpose of review: An increasing amount of research has underscored the significant role of lipoproteins in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). This comprehensive review examines the intr...
Basic and translational evidence supporting the role of TM6SF2 in VLDL metabolism [0.03%]
支持TM6SF2在VLDL代谢中发挥作用的基本和转化证据
Jing Liu,Henry N Ginsberg,Gissette Reyes-Soffer
Jing Liu
Purpose of review: Transmembrane 6 superfamily member 2 ( TM6SF2 ) gene was identified through exome-wide studies in 2014. A genetic variant from glutamic acid to lysine substitution at amino acid position 167 (NM_0010015...
G protein-coupled receptor 146: new insights from genetics and model systems [0.03%]
遗传学和模型系统对G蛋白偶联受体146的新见解
Umesh Tharehalli,Antoine Rimbert
Umesh Tharehalli
Purpose of review: Atherosclerotic cardiovascular diseases continue to be a significant global cause of death. Despite the availability of efficient treatments, there is an ongoing need for innovative strategies to lower ...
Ainara G Cabodevilla,Ni Son,Ira J Goldberg
Ainara G Cabodevilla
Purpose of review: Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotyp...
Janneke W C M Mulder,D Meeike Kusters,Jeanine E Roeters van Lennep et al.
Janneke W C M Mulder et al.
Purpose of review: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of g...
Xiangqiang Shao,Robert Steiner,Amy L Peterson
Xiangqiang Shao
Purpose of review: Newborn screening is one of the most successful public health programs of the last century and offers unparalleled access to universal screening for a variety of metabolic and other disorders. Interest ...
ANGPTL3 and ApoC-III inhibitors for treating hypertriglyceridemia in context: horses for courses? [0.03%]
治疗高甘油三酯血症的ANGPTL3和ApoC-III抑制剂：适合不同患者？
Dick C Chan,Gerald F Watts
Dick C Chan
Purpose of review: Hypertriglyceridemia (HTG) is an independent and casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more effective treatments for patients with HTG. Angiop...