Novel antifungal agents for treating endemic mycoses: hope on the horizon? [0.03%]
治疗土源性真菌病的新抗真菌药物：未来可期？
Nathan C Bahr,Alessandro C Pasqualotto,George R Thompson rd
Nathan C Bahr
Purpose of review: Current treatments for endemic mycoses are limited by toxicity, drug-drug interactions, the need for therapeutic drug monitoring, and suboptimal penetration to sequestered sites. At the same time, sever...
Laura C Steinhardt,Jimee Hwang
Laura C Steinhardt
Purpose of review: Malaria rapid diagnostic tests (RDTs) have revolutionized malaria diagnosis in endemic settings. RDTs are simple to use and accurate for clinical cases, although sensitivity is reduced at parasite densi...
Histoplasmosis in children: emerging insights and evolving guidelines [0.03%]
儿童组织胞浆菌病：新兴认识和不断发展的指南要点
Kate Shapiro,Sandra R Arnold
Kate Shapiro
Purpose of review: This review provides an update on the epidemiology, risk factors, clinical presentation, diagnosis, and management recommendations incorporating recommendations from recent publications including the In...
Michael Blank,Anna Rydlova,Malick M Gibani
Michael Blank
Purpose of review: Typhoidal and invasive non-typhoidal Salmonella (iNTS) serovars remain leading causes of bloodstream infection, mortality and morbidity, particularly in South Asia and sub-Saharan Africa. The rising bur...
Katia C Halabi
Katia C Halabi
Purpose of review: Measles has reemerged as a significant global public health threat, with increasing morbidity and mortality associated with declining vaccination rates. This review summarizes current global outbreaks, ...
Rebecca J Chancey,Paul Cantey
Rebecca J Chancey
Purpose of review: New World screwworm (NWS) is an emerging parasitic threat in Central America and Mexico, which is spreading northward into the southern United States. Here we highlight the changing epidemiology, lifecy...
Unresolved questions in pediatric dengue: from disease mechanisms to prevention [0.03%]
儿童登革热未解之谜：从疾病机制到预防
Eduardo Lopez-Medina
Eduardo Lopez-Medina
Purpose of review: Despite recent advances in understanding dengue infection, substantial gaps remain in its epidemiology, pathogenesis, diagnosis, and prevention, including vaccine development and its long-term impact. T...
Combination therapy for fungal diseases: the role of immunotherapy in the present and the future [0.03%]
真菌病的联合疗法：目前和未来的免疫治疗作用
Laura Seldeslachts,Simon Feys,Frank L van de Veerdonk et al.
Laura Seldeslachts et al.
Purpose of review: Invasive fungal infections remain associated with high morbidity and mortality despite advances in antifungal therapy. Current treatments are largely pathogen-directed and fail to address the dysregulat...
Diana Vilar-Compte,Pamela Garciadiego-Fossas,Cyntia Ibanes-Gutierrez
Diana Vilar-Compte
Purpose of review: This review examines the gap between evidence-based indications for glove use and current practice, and analyzes sustainability and implementation science strategies to optimize their use. ...
Jason E Bowling
Jason E Bowling