Harold S Nelson
Harold S Nelson
Purpose of review: It is likely that approval of allergen preparations for sublingual immunotherapy (SLIT) will soon occur in the United States. This article reviews experience with SLIT in this country, concentrating on ...
Massimo Caruso,Emanuele Crisafulli,Raffaella Lizzio et al.
Massimo Caruso et al.
Purpose of review: Most asthma patients are easily managed with a standard combination of therapies consisting of inhaled controller and reliever drugs, but there remains a large unmet need at the severe end of the diseas...
Anupama Ravi,Matthew A Rank
Anupama Ravi
Purpose of review: To identify and discuss recent articles pertaining to the reduction and management of systemic reactions to allergen immunotherapy (AIT). ...
Pathogenic mechanisms and clinical implications of congenital neutropenia syndromes [0.03%]
先天性中性粒细胞减少综合症的发病机制及临床意义
Fabian Hauck,Christoph Klein
Fabian Hauck
Purpose of review: The purpose of this review is to summarize pathogenic mechanisms and clinical implications of the most illustrative genetic entities of congenital neutropenia syndromes. ...
Emmanuelle Jouanguy,Laure Gineau,Julien Cottineau et al.
Emmanuelle Jouanguy et al.
Purpose of review: Inborn errors of human natural killer (NK) cells may affect the development of these cells, their function, or both. There are two broad categories of genetic defects of NK cell development, depending o...
Helen Chapel,Ann Gardulf
Helen Chapel
Purpose of review: Rapid subcutaneous immunoglobulin (SCIg) infusions have been used as an important method of delivering replacement immunoglobulin (Ig) to patients with primary immune deficiencies (PIDs) in Europe over ...
B-cell memory and primary immune deficiencies: interleukin-21 related defects [0.03%]
B细胞记忆和原发性免疫缺陷：白细胞介素-21相关缺陷
Marylin Desjardins,Bruce D Mazer
Marylin Desjardins
Purpose of review: The purpose of this study is to describe recent advances in our understanding of the role of interleukin-21 (IL-21) in B-cell maturation, and how defects in IL-21 receptor (IL-21R) signalling pathways (...
Safety and tolerability of sublingual immunotherapy in clinical trials and real life [0.03%]
舌下免疫疗法临床试验及实际应用中的安全性与耐受性研究
Gianenrico Senna,Marco Caminati,Giorgio Walter Canonica
Gianenrico Senna
Purpose of review: Sublingual immunotherapy (SLIT) is effective in allergic rhinitis and asthma. Apart from its efficacy, safety is crucial as this treatment is usually self-administered at home. Tolerability also plays a...