Julijana Asllani,Eleni Anastasiou,Nikolaos G Papadopoulos
Julijana Asllani
Purpose of review: Allergen immunotherapy (AIT) remains the only disease-modifying treatment for respiratory allergic diseases and the only intervention capable of preventing systemic sting reactions in patients with veno...
Precision allergy molecular diagnostic applications in anaphylaxis: from triggers to risk stratification and personalized management [0.03%]
精准过敏分子诊断在过敏性休克中的应用：从致病因素到风险分层和个性化治疗
René Maximiliano Gómez,Mário Morais-Almeida,Ignacio J Ansotegui
René Maximiliano Gómez
Purpose of review: Precision allergy molecular diagnostic applications (PAMD@), previously referred to as component-resolved diagnosis (CRD), has progressively transformed the diagnostic approach to anaphylaxis. This revi...
Mas-related G protein-coupled receptor X2 in non-IgE-mediated mast cell activation and anaphylaxis: a paradigm shift [0.03%]
MAS相关G蛋白偶联受体X2在非IgE介导的肥大细胞活化和过敏性休克中的作用：一个范式转变
Marco Zurlo,Francesca Levi-Schaffer
Marco Zurlo
Purpose of review: The understanding of anaphylaxis has evolved over time beyond the classical IgE-mediated paradigm. This review examines the role of Mas-related G protein-coupled receptor X2 (MRGPRX2) in non-IgE-mediate...
Microbiota and anaphylaxis: emerging insights into immune regulation and clinical implications [0.03%]
微生物群和过敏反应：免疫调节与临床意义的新见解
Martina Ottoni,Antonio Nouvenne,Erminia Ridolo
Martina Ottoni
Purpose of review: Anaphylaxis is a life-threatening systemic hypersensitivity reaction with highly variable clinical expression and unpredictable severity. Increasing evidence suggests that host-microbiota interactions m...
Victoria Cardona,Anna Sala-Cunill
Victoria Cardona
Purpose of review: Anaphylaxis attributable to non-immunoglobulin E (IgE)-mediated mechanisms represents an increasingly recognized and clinically challenging subset of severe hypersensitivity reactions. This review synth...
Anaphylaxis in pregnancy: diagnostic blind spots, epinephrine hesitancy, and emerging prevention strategies [0.03%]
妊娠期过敏性休克：诊断盲点、肾上腺素使用犹豫以及新兴的预防策略
Luciana Kase Tanno,Pascal Demoly
Luciana Kase Tanno
Purpose of review: Anaphylaxis during pregnancy is uncommon but remains one of the most critical emergencies in obstetric medicine because maternal deterioration and fetal hypoxia evolve simultaneously. Despite establishe...
Giada Crescioli,Costanza Cacini,Francesco Catamerò et al.
Giada Crescioli et al.
Purpose of review: Biosimilars are increasingly shaping the management of pediatric allergic diseases and offering cost-effective alternatives to originator biology. This review summarizes the scientific and regulatory pr...
Chiara Lo Presti,Licia Peruzzi,Francesco Licciardi
Chiara Lo Presti
Purpose of review: Systemic lupus erythematosus (SLE) is typically considered an acquired disease; nevertheless, a growing body of evidence suggests that, particularly in patients with severe disease and early onset, SLE ...
Circadian control of innate immunity: molecular mechanisms and implications for allergic disorders [0.03%]
昼夜节律调节先天免疫：分子机制及其对过敏的影响
Ammar Nahas,Daniel Zammit Lupi,Beatriz Nunez Colao et al.
Ammar Nahas et al.
Purpose of review: Circadian clocks are increasingly recognized as fundamental regulators of innate immune function, yet their relevance to allergy and clinical immunology has only recently been clarified. This review sum...
Probiotics in allergic disease: from adjunct supplement to immune-modifying strategy (2026 update) [0.03%]
益生菌与过敏性疾病：从辅助补充到免疫调节策略（2026年更新）
Giorgio S Raho
Giorgio S Raho
Purpose of review: Allergic diseases continue to increase globally, and accumulating evidence implicates early-life microbial exposures as central determinants of immune tolerance. This review synthesizes advances from 20...