Histone deacetylases and their inhibitors: new implications for asthma and chronic respiratory conditions [0.03%]
组蛋白去乙酰酶及其抑制剂：对哮喘和慢性呼吸系统疾病的新的影响
Simon G Royce,Tom C Karagiannis
Simon G Royce
Purpose of review: The importance of the role of histone deacetylase enzymes in the pathogenesis of asthma and chronic respiratory diseases is increasingly being recognized. Similarly, the potential clinical utility of hi...
The association between acetaminophen and asthma: is there anything to learn from the upper airways? [0.03%]
对乙酰氨基酚与哮喘的关系：还能从上呼吸道方面得到什么启示吗？
Haejin Kim,Christine C Johnson
Haejin Kim
Purpose of review: To examine the literature evidence for the association between acetaminophen (paracetamol) use and development of rhinitis. Recent find...
Innate lymphoid cells in asthma: when innate immunity comes in a Th2 flavor [0.03%]
哮喘小体：当先天免疫披上2型淋巴细胞的外衣
Donata Vercelli,Justyna Gozdz,Erika von Mutius
Donata Vercelli
Purpose of review: Asthma is typically considered as an immunologic Th2 cell-mediated disease, a notion that is still inspiring many therapeutic strategies. In the past years, however, an innate immune cell type has been ...
Jun Zhong,Michael Roth
Jun Zhong
Purpose of review: To summarize the new knowledge on tissue remodeling in the context of lung diseases. Tissue remodeling includes changes in cells: differentiation; response to growths factors, hormones, or environmental...
An update on the pathogenesis of the upper airways in aspirin-exacerbated respiratory disease [0.03%]
一氧化氮呼气试验在阿司匹林加重性呼吸系统疾病上呼吸道发病机制中的作用
Jeong-Hee Choi,Mi-Ae Kim,Hae-Sim Park
Jeong-Hee Choi
Purpose of review: The key features of aspirin-exacerbated respiratory diseases (AERDs) include chronic, severe asthma and a high prevalence (60-80%) of chronic rhinosinusitis with nasal polyps, all of which are exacerbat...
Dendritic cell c-kit signaling and adaptive immunity: implications for the upper airways [0.03%]
树突状细胞c-kit信号转导与适应性免疫应答：上呼吸道相关问题的启示
Timothy B Oriss,Nandini Krishnamoorthy,Prabir Ray et al.
Timothy B Oriss et al.
Purpose of review: Binding of the receptor tyrosine kinase, c-kit, to its ligand, stem cell factor (SCF), mediates numerous biological functions. Important roles for c-kit in hematopoiesis, melanogenesis, erythropoiesis, ...
The rhinitis control assessment test: implications for the present and future [0.03%]
鼻炎控制评估测试：目前和未来的启示
Robert A Nathan
Robert A Nathan
Purpose of review: To summarize the development of the Rhinitis Control Assessment Test (RCAT), its usefulness in clinical practice, and the benefit it provides for patients who are bothered by allergic and nonallergic rh...
Finn Rasmussen,Robert J Hancox
Finn Rasmussen
Purpose of review: Obesity and asthma are chronic conditions affecting millions of people worldwide. The two conditions also appear to be linked with an increased risk of asthma in people who are obese. The purpose of thi...
Adult asthma biomarkers [0.03%]
成人哮喘生物标志物
Mi-Ae Kim,Yoo Seob Shin,Le Duy Pham et al.
Mi-Ae Kim et al.
Purpose of review: A variety of novel asthma treatments have been developed based on phenotypes, and the clinical trial results show promising responses. This review summarizes the current knowledge of biomarkers for the ...
New approaches to transcutaneous immunotherapy: targeting dendritic cells with novel allergen conjugates [0.03%]
透皮免疫疗法的新方法：用新型过敏原缀合物靶向树突状细胞
Richard Weiss,Sandra Scheiblhofer,Yoan Machado et al.
Richard Weiss et al.
Purpose of review: This review summarizes recent preclinical and human studies evaluating allergen-specific immunotherapy via the transcutaneous route, and provides a rationale for the application of modified allergens wi...