GATA2 deficiency [0.03%]
GATA2缺乏症
Amy P Hsu,Lisa J McReynolds,Steven M Holland
Amy P Hsu
Purpose of review: GATA2 deficiency is a germline disease that causes a wide spectrum of phenotypes including viral and bacterial infections, cytopenias, myelodysplasia, myeloid leukemias, pulmonary alveolar proteinosis a...
Mark Ballow
Mark Ballow
Purpose of review: In the past few years there have been many advances in our understanding of the mechanisms by which intravenous immune globulin (IVIG) modulates immune function in autoimmune disorders. ...
When less is more: primary immunodeficiency with an autoinflammatory kick [0.03%]
当少即多：原发性免疫缺陷伴自身炎症性表现
Angeliki Giannelou,Qing Zhou,Daniel L Kastner
Angeliki Giannelou
Purpose of review: Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that targe...
Discovering susceptibility genes for allergic rhinitis and allergy using a genome-wide association study strategy [0.03%]
采用全基因组关联研究策略发现过敏性鼻炎和过敏易感基因
Jingyun Li,Yuan Zhang,Luo Zhang
Jingyun Li
Purpose of review: Allergic rhinitis and allergy are complex conditions, in which both genetic and environmental factors contribute to the pathogenesis. Genome-wide association studies (GWASs) employing common single-nucl...
Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis [0.03%]
苦味受体T2R38在上呼吸道感染和慢性鼻窦炎中的作用
Robert J Lee,Noam A Cohen
Robert J Lee
Purpose of review: Taste receptor family 2 (T2R) bitter taste receptors were originally identified and named on the basis of their role in type 2 taste cells of the tongue, in which they serve to detect the presence of po...
Marek Jutel,Cezmi A Akdis
Marek Jutel
Purpose of review: Allergen-specific immunotherapy is the only curative treatment for allergic diseases. In spite of the great progress in both vaccine development and the methods of allergen immunotherapy (AIT) in recent...
Stem cell transplantation for primary immunodeficiencies: the European experience [0.03%]
造血干细胞移植治疗原发性免疫缺陷病的欧洲经验
Marina Cavazzana,Fabien Touzot,Despina Moshous et al.
Marina Cavazzana et al.
Purpose of review: Primary immunodeficiencies (PIDs) constitute a heterogeneous group of inherited disorders affecting the development and/or function of the immune system. This review focuses on the recent advances in he...
Stem cell transplantation for primary immunodeficiency diseases: the North American experience [0.03%]
造血干细胞移植治疗原发性免疫缺陷病的北美洲经验
Sung-Yun Pai,Morton J Cowan
Sung-Yun Pai
Purpose of review: This review describes recent studies on outcomes after allogeneic hematopoietic cell transplantation for primary immunodeficiency in North America, including severe combined immunodeficiency (SCID), Wis...
Jean-Pierre Allam,Natalija Novak
Jean-Pierre Allam
Purpose of review: This review aims to recap recent published data on immunological mechanisms underlying sublingual immunotherapy (SLIT). Recent findings...
Gerhard Kindle,Benjamin Gathmann,Bodo Grimbacher
Gerhard Kindle
Purpose of review: We provide an overview on the latest developments in primary immunodeficiency registries worldwide, on the basis of the recent literature amended by some older references to achieve completeness. ...