An evidence based therapeutic approach to hereditary and acquired angioedema [0.03%]
基于证据的遗传性和获得性血管水肿治疗方法
Konrad Bork
Konrad Bork
Purpose of review: Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (HAE-C1-INH), HAE with normal C1-INH, and acquired angioedema due to C1-INH deficiency are rare but important diseases that c...
Bernard Y Thong,Miguel Blanca
Bernard Y Thong
Pharmacotherapy in refractory anaphylaxis: when intramuscular epinephrine fails [0.03%]
难治性过敏性休克的药物治疗：当肌肉注射肾上腺素无效时
Ann M Kemp,Stephen F Kemp
Ann M Kemp
Purpose of review: This review aims to provide an evidence-based overview of several pharmacotherapeutic options available for refractory anaphylaxis when intramuscular epinephrine, the drug of choice, fails to provide re...
Update on the understanding, diagnosis and tailored management of anaphylaxis: making progress [0.03%]
过敏性休克的诊治进展：如何有的放矢？
Gianenrico Senna,Jeffrey G Demain
Gianenrico Senna
Cheryl S Hankin,Linda Cox
Cheryl S Hankin
Purpose of review: Given the widespread prevalence of allergic disease, its substantially associated clinical and economic burden, the unique disease-modifying benefits of allergy immunotherapy (AIT), and increased availa...
The importance of hapten-protein complex formation in the development of drug allergy [0.03%]
药物过敏中hapten-蛋白复合物形成的重要性
Lee Faulkner,Xiaoli Meng,B Kevin Park et al.
Lee Faulkner et al.
Purpose of review: Drug allergy is an adverse drug reaction that is immune-mediated. Immune activation can occur when drugs or haptens bind covalently to proteins and then act as antigens. The purpose of this review is to...
Allen P Kaplan,Todor A Popov
Allen P Kaplan
Purpose of review: Chronic spontaneous urticaria (CSU) has been traditionally managed with antihistamines. Over the years, studies using different formulations and dosing regimens have delineated the limits of their effec...
Massimo Triggiani,Marcello Montagni,Roberta Parente et al.
Massimo Triggiani et al.
Purpose of review: Anaphylaxis is a life-threatening event in which the cardiovascular system is responsible for the majority of clinical symptoms and for potentially fatal outcome. This review summarizes the most recent ...
Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: from phenotyping to genotyping [0.03%]
非甾体抗炎药超敏反应研究从表型到基因型
Natalia Blanca-López,Ester Barrionuevo,Inmaculada Andreu et al.
Natalia Blanca-López et al.
Purpose of review: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent drugs involved in hypersensitivity drugs reactions. Both immunological and nonimmunological mechanisms can be involved. We describe th...
Camilla Stephens,Raúl J Andrade,M Isabel Lucena
Camilla Stephens
Purpose of review: Idiosyncratic drug-induced liver injury (iDILI) is a relatively rare condition, but can have serious consequences for the individual patient, public health, regulatory agencies and the pharmaceutical in...