Patrick Bez,Martina Ceraudo,Fabrizio Vianello et al.
Patrick Bez et al.
Purpose of review: The purpose of the review is to describe the most recent advancement in understanding of the pivotal role of autoimmune regulator ( AIRE ) gene expression in central and peripheral tolerance, and the im...
The biological basis for current treatment strategies for granulomatous disease in common variable immunodeficiency [0.03%]
常见变量免疫缺陷型肉芽肿病的当前治疗策略的生物学基础
Astrid C van Stigt,Giulia Gualtiero,Francesco Cinetto et al.
Astrid C van Stigt et al.
Purpose of review: The pathogenesis of granulomatous disease in common variable immunodeficiency (CVID) is still largely unknown, which hampers effective treatment. This review describes the current knowledge on the patho...
Hereditary angioedema due to C1-inhibitor deficiency: current therapeutic approaches [0.03%]
C1酯酶抑制剂缺乏所致遗传性血管水肿的当前治疗措施
Giulia Costanzo,Giada Sambugaro,Davide Firinu
Giulia Costanzo
Purpose of review: For decades, treatment options for hereditary angioedema (HAE) were limited by major adverse effects, insufficient efficacy, and difficult routes of administration. However, the growing body of knowledg...
Bridging the gap: neurodevelopmental disorder risks in inborn errors of immunity [0.03%]
从先天性免疫缺陷到神经发育障碍风险：建立桥梁关系
Devika Kurup,Amy M FitzPatrick,Aleksandra Badura et al.
Devika Kurup et al.
Purpose of review: The aim of this review is to examine published reports of neurodevelopmental phenotypes in patients with inborn errors of immunity (IEI). We briefly discuss potential interactions between the immune and...
Natalia Rodríguez-Otero,Elena Ramírez-Mateo,Maria Nieves Plana et al.
Natalia Rodríguez-Otero et al.
Purpose of review: Allergic rhinitis is a relevant and global health problem affecting up to 5-50% of the general population and its prevalence is increasing due to climate change and pollution among other factors and cou...
Yaroslav Andrew Jakymec,Justin Greiwe,Jonathan A Bernstein
Yaroslav Andrew Jakymec
Purpose of review: This review comes at a time where new techniques in immunotherapy administration are being developed, new innovations are being incorporated to standard techniques, and new regulations are being adopted...
Allergen-specific immunotherapy at the extremes of age: below 5 years and elderly: evidence beyond indications? [0.03%]
特应免疫疗法用于极小年龄和老年患者：适应证之外的证据？
Cansu Özdemiral,Deniz Ilgun Gurel,Umit Sahiner
Cansu Özdemiral
Purpose of review: Allergen-specific immunotherapy (AIT) has been used in clinical practice to treat allergic diseases for over 100 years. The effectiveness and safety of AIT have been substantiated in numerous studies; h...
Patrick Bez,Klaus Warnatz
Patrick Bez
Purpose of review: Liver disease has emerged as a major risk factor for increased mortality in patients with common variable immunodeficiency (CVID). This is mostly due to presinusoidal portal hypertension (PHTN) frequent...
Inês Pais-Cunha,Cristina Jácome,Rafael Vieira et al.
Inês Pais-Cunha et al.
Purpose of review: This review explores the relevance of eHealth technologies to address unmet needs in pediatric respiratory allergies, particularly allergic rhinitis (AR) and asthma. Given the increasing burden of these...
Constantinos Pitsios,Carlo Maria Rossi
Constantinos Pitsios
Purpose of review: The connection between eosinophilic esophagitis (EoE) and food and airborne allergens is complex. Exposure to allergens (mainly food) is often the trigger for EoE flares. The development of EoE has been...