The immunopathology of keratoconus: tear film biomarkers and immune pathways [0.03%]
角膜扩张的免疫病理学：泪液生物标志物和免疫途径
Marco Lombardo,Mario Fruschelli,Sebastiano Serrao
Marco Lombardo
Purpose of review: This review explores established risk factors for keratoconus and current insights into tear film immune biomarkers, with a focus on the role of chronic low-grade inflammation in disease pathogenesis an...
Alessandro Barone,Francesca Nicoletta,Martina Ottoni et al.
Alessandro Barone et al.
Purpose of review: Anaphylaxis in elderly is a little-known topic, despite the worldwide growth of this part of the population. In this review, the main elicitors are discussed, with a particular regard for risk factors, ...
Xin-Rong Lim,Bernard Yu-Hor Thong
Xin-Rong Lim
Purpose of review: Among the various manifestations of perioperative hypersensitivity (POH), skin reactions are often the first and most visible signs of an allergic or hypersensitivity response to drugs, antiseptics, or ...
Jessy Elst,Didier G Ebo,Vito Sabato
Jessy Elst
Purpose of review: Mast cell degranulation in anaphylaxis can result from both IgE-dependent and IgE-independent mechanisms. The two conditions differ in terms of phenotype, diagnosis and specific therapeutic targets. ...
Advances in the treatment of anaphylaxis: intranasal and sublingual versus intramuscular epinephrine [0.03%]
过敏性休克治疗新进展：鼻内给药和舌下给药与肌肉注射肾上腺素的比较研究
Jay Adam Lieberman,Matthew Greenhawt
Jay Adam Lieberman
Purpose of review: Epinephrine is universally considered the standard of care for the treatment of severe allergic reactions, including anaphylaxis, and, until recently, was preferentially recommended to be given intramus...
Paul J Turner
Paul J Turner
Purpose of review: Air travel has now returned to prepandemic levels, with over 10.5 billion passengers in 2024. Many of these passengers have food allergies, and there is a perception that allergic reactions are common d...
David González-de-Olano,Iván Álvarez-Twose
David González-de-Olano
Purpose of review: Among patients with hymenoptera venom allergy (HVA), a high proportion have an underlying systemic mastocytosis. It is essential to identify them for an adequate management. ...
Editorial: pharmacotherapy and evidence-based medicine in allergy and clinical immunology-2025 updates and perspectives [0.03%]
述评：过敏及临床免疫学的药物治疗和循证医学（2025更新版）
Giovanni Paoletti,Edoardo Cavaglià,Andrea Di Biase et al.
Giovanni Paoletti et al.
The role of regulatory T cells in preventing the development of drug hypersensitivity reactions [0.03%]
调节性T细胞在预防药物过敏反应发生中的作用
Lonnie MacDonald,Megan Mitchell,Paul Thomson
Lonnie MacDonald
Purpose of review: T-cell-mediated drug hypersensitivity reactions represent a major impediment to the drug discovery process whilst presenting a significant burden to the healthcare sector. These reactions are predominan...
Algorithms for the classification of patients with a β-lactam allergy label: a systematic review [0.03%]
β-内酰胺类抗生素过敏患者的分类算法：系统评价
Joana Sousa,Joana Balseiro,Mariana Barreto et al.
Joana Sousa et al.
Purpose of review: Beta-lactam allergy is frequently reported, but only a minority of cases correspond to true allergies. Tools to stratify the risk of a real allergic reaction can possibly help delabeling patients. We ai...