Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis [0.03%]
苦味受体T2R38在上呼吸道感染和慢性鼻窦炎中的作用
Robert J Lee,Noam A Cohen
Robert J Lee
Purpose of review: Taste receptor family 2 (T2R) bitter taste receptors were originally identified and named on the basis of their role in type 2 taste cells of the tongue, in which they serve to detect the presence of po...
Marek Jutel,Cezmi A Akdis
Marek Jutel
Purpose of review: Allergen-specific immunotherapy is the only curative treatment for allergic diseases. In spite of the great progress in both vaccine development and the methods of allergen immunotherapy (AIT) in recent...
Stem cell transplantation for primary immunodeficiencies: the European experience [0.03%]
造血干细胞移植治疗原发性免疫缺陷病的欧洲经验
Marina Cavazzana,Fabien Touzot,Despina Moshous et al.
Marina Cavazzana et al.
Purpose of review: Primary immunodeficiencies (PIDs) constitute a heterogeneous group of inherited disorders affecting the development and/or function of the immune system. This review focuses on the recent advances in he...
Stem cell transplantation for primary immunodeficiency diseases: the North American experience [0.03%]
造血干细胞移植治疗原发性免疫缺陷病的北美洲经验
Sung-Yun Pai,Morton J Cowan
Sung-Yun Pai
Purpose of review: This review describes recent studies on outcomes after allogeneic hematopoietic cell transplantation for primary immunodeficiency in North America, including severe combined immunodeficiency (SCID), Wis...
Jean-Pierre Allam,Natalija Novak
Jean-Pierre Allam
Purpose of review: This review aims to recap recent published data on immunological mechanisms underlying sublingual immunotherapy (SLIT). Recent findings...
Gerhard Kindle,Benjamin Gathmann,Bodo Grimbacher
Gerhard Kindle
Purpose of review: We provide an overview on the latest developments in primary immunodeficiency registries worldwide, on the basis of the recent literature amended by some older references to achieve completeness. ...
Progress in gene therapy for primary immunodeficiencies using lentiviral vectors [0.03%]
改良 Lentiviral载体进行基因治疗以改善原发性免疫缺陷病的研究进展
Aisha V Sauer,Biagio Di Lorenzo,Nicola Carriglio et al.
Aisha V Sauer et al.
Purpose of review: This review gives an overview over the most recent progress in the field of lentiviral gene therapy for primary immunodeficiencies (PIDs). The history and state-of-the-art of lentiviral vector developme...
Nicole Pleskovic,Ashton Bartholow,David P Skoner
Nicole Pleskovic
Purpose of review: Sublingual immunotherapy (SLIT) is indicated for the use in pediatric patients suffering from allergic rhinitis or allergic rhinoconjunctivitis caused by environmental allergens, such as ragweed pollen,...
Simone M Hayen,Atanaska I Kostadinova,Johan Garssen et al.
Simone M Hayen et al.
Purpose of review: Despite reaching high percentages of desensitization using allergen-specific immunotherapy (SIT) in patients with food allergy, recent studies suggest only a low number of patients to reach persistent c...
Anti-interleukin 4 and 13 for asthma treatment in the era of endotypes [0.03%]
终结型时代的抗IL-4和抗IL-13哮喘治疗
Andrew L Kau,Phillip E Korenblat
Andrew L Kau
Purpose of review: To summarize recent advances in IL-4 and IL-13 blockade in the treatment of asthma. Recent findings: Historically, a...