Fulvio Braido,Ilaria Baiardini,Francesco Blasi et al.
Fulvio Braido et al.
Purpose of review: To highlight the state of the art and the current outlook on the adherence to treatment in asthma, starting from the 'Manifesto on Adherence to asthma treatment in respiratory allergy' endorsed by the W...
Ruby Pawankar,Miyuki Hayashi,Shingo Yamanishi et al.
Ruby Pawankar et al.
Purpose of review: Cytokines are immunomodulatory proteins important in cell signaling. Complex interactions of innate and adaptive immune cells, as well as structural cells and their cytokines, play crucial roles in regu...
Claudina A Pérez-Novo,Claus Bachert
Claudina A Pérez-Novo
Purpose of review: DNA methylation is an epigenetic mechanism that has been implicated in the pathogenesis of chronic inflammatory diseases by regulating differentiation, proliferation, apoptosis, and activation of immune...
Jin-Young Min,Bruce K Tan
Jin-Young Min
Purpose of review: To review the recent literature on risk factors for chronic rhinosinusitis (CRS) with an emphasis on genetic, comorbid diseases and environmental factors associated with CRS. Through identifying potenti...
Gene-environment interactions in the study of asthma in the postgenomewide association studies era [0.03%]
全基因组关联研究后哮喘的遗传-环境交互作用研究
Marta Rava,Lidwien A M Smit,Rachel Nadif
Marta Rava
Purpose of review: Asthma is a complex disease characterized by an intricate interplay of both heritable and environmental factors. Understanding the mechanisms through which genes and environment interact represents one ...
Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation [0.03%]
上皮细胞源性细胞因子（IL-33、IL-25 和胸腺间质淋巴细胞生成素）与过敏性疾病炎症的最新研究进展
Rohit Divekar,Hirohito Kita
Rohit Divekar
Purpose of review: Allergic diseases are thought to be driven by aberrant immune responses. Epithelium responds to various environmental factors by releasing key cytokines, such as thymic stromal lymphopoietin (TSLP), IL-...
GATA2 deficiency [0.03%]
GATA2缺乏症
Amy P Hsu,Lisa J McReynolds,Steven M Holland
Amy P Hsu
Purpose of review: GATA2 deficiency is a germline disease that causes a wide spectrum of phenotypes including viral and bacterial infections, cytopenias, myelodysplasia, myeloid leukemias, pulmonary alveolar proteinosis a...
Mark Ballow
Mark Ballow
Purpose of review: In the past few years there have been many advances in our understanding of the mechanisms by which intravenous immune globulin (IVIG) modulates immune function in autoimmune disorders. ...
When less is more: primary immunodeficiency with an autoinflammatory kick [0.03%]
当少即多：原发性免疫缺陷伴自身炎症性表现
Angeliki Giannelou,Qing Zhou,Daniel L Kastner
Angeliki Giannelou
Purpose of review: Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that targe...
Discovering susceptibility genes for allergic rhinitis and allergy using a genome-wide association study strategy [0.03%]
采用全基因组关联研究策略发现过敏性鼻炎和过敏易感基因
Jingyun Li,Yuan Zhang,Luo Zhang
Jingyun Li
Purpose of review: Allergic rhinitis and allergy are complex conditions, in which both genetic and environmental factors contribute to the pathogenesis. Genome-wide association studies (GWASs) employing common single-nucl...