Annick A J M van de Ven,Klaus Warnatz
Annick A J M van de Ven
Purpose of review: Autoimmune and inflammatory manifestations are the biggest clinical challenge in the care of patients with common variable immunodeficiency (CVID). The increasing pathogenic knowledge and potential ther...
Désirée Larenas-Linnemann
Désirée Larenas-Linnemann
Purpose of review: With the Food and Drug Administration's approval of sublingual allergen-specific immunotherapy (SL-AIT) tablets for grass and ragweed pollen, SL-AIT is progressively gathering importance not only in Eur...
The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome [0.03%]
X连锁免疫失调综合征的免疫学和遗传学基础
Khalid Bin Dhuban,Ciriaco A Piccirillo
Khalid Bin Dhuban
Purpose of review: This article presents a comprehensive review of the immunodysregulation, polyendocrinopathy, enteropathy and X-linked (IPEX) syndrome, covering both the clinical and molecular aspects of the disease. (F...
Newborn screening for severe combined immune deficiency (technical and political aspects) [0.03%]
严重联合免疫缺陷的新生儿筛查（技术和政治方面）
Lisa Kobrynski
Lisa Kobrynski
Purpose of review: Newborn screening for severe combined immune deficiency (SCID) has been implemented in more than half of the states in the United States. Despite the success of these programs, numerous challenges remai...
Zahra Aryan,Nima Rezaei
Zahra Aryan
Purpose of review: Toll-like receptors (TLRs) are novel and promising targets for allergen immunotherapy. Bench studies suggest that TLR agonists reduce Th2 responses and ameliorate airway hyper-responsiveness. In additio...
Fatima Dhalla,Siraj A Misbah
Fatima Dhalla
Purpose of review: Antibody deficiency can occur in the context of primary immune deficiency due to inherited genetic defects or secondary to a variety of causes. This review aims to summarize current data concerning the ...
Gain-of-function mutations and immunodeficiency: at a loss for proper tuning of lymphocyte signaling [0.03%]
功能获得性突变与免疫缺陷：淋巴细胞信号转导的调节失常
Swadhinya Arjunaraja,Andrew L Snow
Swadhinya Arjunaraja
Purpose of review: To present recent advances in the discovery and characterization of new immunodeficiency disorders linked to gain-of-function (GOF) mutations in immune signaling molecules. (Figure is included in full-t...
Faheem Latheef,Stephen Mark Wilkinson
Faheem Latheef
Purpose of review: The aim of this review was to examine the current outbreak of cases of contact allergy to methylisothiazolinone in Europe, a phenomenon that has also been observed worldwide, despite initial legislative...
Current novel approaches in systemic therapy of atopic dermatitis: specific inhibition of cutaneous Th2 polarized inflammation and itch [0.03%]
特应性皮炎系统治疗的最新方法：皮肤Th2炎症和止痒的特异性抑制
Thomas Werfel,Tilo Biedermann
Thomas Werfel
Purpose of review: This present review gives an overview on different approaches on systemic treatment of atopic dermatitis with a focus on molecules that are presently investigated as defined target structures in clinica...
Sergio E Chiarella,Rafle Fernandez,Pedro C Avila
Sergio E Chiarella
Purpose of review: In this review, we summarize the latest publications on the genetic and environmental determinants of allergic rhinitis. Recent finding...