An-Soo Jang,Young Joon Jun,Moo Kyun Park
An-Soo Jang
Purpose of review: We discuss the effects of air pollutants on upper airway disease; the topic has hitherto received little attention. Recent findings: ...
Hongfei Lou,Chengshuo Wang,Luo Zhang
Hongfei Lou
Purpose of review: Chronic rhinosinusitis (CRS) is a challenging disease entity, affecting 8-15% of the general population. Topical steroids have been recommended as an integral part of the strategy for management of CRS....
Differential short palate, lung, and nasal epithelial clone 1 suppression in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps: implications for pathogenesis and treatment [0.03%]
变应性和非变应性鼻息肉中SPLUNC1的不同抑制及其发病机制和治疗的含义
Yi Wei,Miaomiao Han,Weiping Wen et al.
Yi Wei et al.
Purpose of review: Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) is an epithelium-secreted protein that is involved in innate immunity. A protective role for SPLUNC1 in lower respiratory inflammation and chro...
Sarah Vreugde,Peter-John Wormald
Sarah Vreugde
Purpose of review: Innate lymphoid type 2 cells (ILC2) have a critical role in the initiation and regulation of type 2 immune responses and are recognized as an important source of type-2 cytokines. Here, we present recen...
Lorenzo Cosmi,Francesco Liotta,Francesco Annunziato
Lorenzo Cosmi
Purpose of review: Th17 lymphocytes are now widely believed to be critical for the regulation of various chronic immune diseases, including asthma and chronic obstructive pulmonary disease. In this review, we discuss the ...
Matteo Ferrando,Diego Bagnasco,Fulvio Braido et al.
Matteo Ferrando et al.
Purpose of review: This article realizes an overview on the world of biological and biosimilar drugs in allergic and immunologic diseases' treatment strategies. We started talking about the history of asthma treatment's p...
Stephen Holding,Stephen Jolles
Stephen Holding
Purpose of review: Diagnostic delay is a major problem for rare diseases including primary antibody deficiency (PAD). The aim of this review is to discuss the opportunities and challenges of current and future screening a...
Erik Wambre
Erik Wambre
Purpose of review: The aims of this review are to discuss the impact of chronic high-dose allergen exposure on allergen-specific CD4(+) T-cell subset during allergen-specific immunotherapy (AIT) and discuss recent advance...
Mark Gorelik,Pamela A Frischmeyer-Guerrerio
Mark Gorelik
Purpose of review: In allergic disease, dendritic cells play a critical role in orchestrating immune responses to innate stimuli and promoting the formation of T helper 2 (TH2) effector versus T-regulatory cells. Here, we...
Désirée Larenas-Linnemann
Désirée Larenas-Linnemann
Purpose of review: Allergen immunotherapy (AIT) is still the only causal treatment for allergic rhinitis and asthma. However, conventional subcutaneous AIT administration schedules are time-consuming and safety issues sti...