Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps [0.03%]
IL-25作为慢性鼻窦炎和鼻息肉治疗的新靶点
Mingyu Lee,Dae Woo Kim,Hyun-Woo Shin
Mingyu Lee
Purpose of review: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disorder with a poorly understood pathophysiology. Recent findings show that epithelial-derived cytokines, including thy...
Dendritic cell subset expression in severe chronic rhinosinusitis with nasal polyps [0.03%]
伴有鼻息肉的严重慢性鼻窦炎中树突状细胞亚群的表达
Claudina Perez-Novo,Rogério Pezato
Claudina Perez-Novo
Purpose of review: Two main pillars are implicated in nasal polyposis development: a severe imbalance in immunomodulation and a mechanical dysfunction because of an abnormal remodeling process. Dendritic cells play a cruc...
Asthma-chronic obstructive pulmonary disease overlap syndrome: a controversial concept [0.03%]
哮喘-慢性阻塞性肺病重叠综合征：一个有争议的概念
Gustavo J Rodrigo,Hugo Neffen,Vicente Plaza
Gustavo J Rodrigo
Purpose of review: To illustrate the scant evidence and the shortcomings of the concept of 'asthma-COPD overlap syndrome' (ACOS) in terms of clinical utility. ...
Magdalena M Gorska
Magdalena M Gorska
Purpose of review: This review article discusses current knowledge on natural killer (NK) cells in asthma. Recent findings: It is now w...
Anticytokine autoantibodies in infection and inflammation: an update [0.03%]
感染和炎症中的抗细胞因子自身抗体：最新研究进展
Gabriela Barcenas-Morales,Peter Jandus,Rainer Döffinger
Gabriela Barcenas-Morales
Purpose of review: Concise overview of the field of anticytokine autoantibodies with a focus on recent developments. Recent findings: A...
No! When the immunologist becomes a virologist: Norovirus - an emerging infection in immune deficiency diseases [0.03%]
当免疫学家成为病毒学家时——诺如病毒感染在免疫缺陷病中的流行与防治
Stella Hartono,Amrita Bhagia,Avni Y Joshi
Stella Hartono
Purpose of review: Norovirus infection is an emerging chronic infection in immunocompromised hosts. The aim of this review is to discuss the pathophysiology of Norovirus infection and explore mechanistic models for chroni...
Ulrich Wahn
Ulrich Wahn
Purpose of review: Currently, dramatic changes in allergy treatment can be observed in many countries: The availability of monocomponent products with pharmaceutical quality for sublingual immunotherapy is likely to have ...
Venetia Bigley,Dawn Barge,Matthew Collin
Venetia Bigley
Purpose of review: Dendritic cells are specialized antigen-presenting cells which link innate and adaptive immunity, through recognition and presentation of antigen to T cells. Although the importance of dendritic cells h...
Requirements for human natural killer cell development informed by primary immunodeficiency [0.03%]
人天然杀伤细胞发育的需求主要由免疫缺陷决定
Emily M Mace
Emily M Mace
Purpose of review: Human natural killer (NK) cell development is poorly understood; however, we gain important insight from cases of human primary immunodeficiency that affect the generation of mature human NK cell subset...
Novel tools for primary immunodeficiency diagnosis: making a case for deep profiling [0.03%]
原发性免疫缺陷诊断的新工具：深入分析案例
Elena W Y Hsieh,Joseph D Hernandez
Elena W Y Hsieh
Purpose of review: This review gives an overview of the systems-immunology single-cell proteomic and transcriptomic approaches that can be applied to study primary immunodeficiency. It also introduces recent advances in m...