Update on questionnaires for assessing adherence to inhaler devices in respiratory patients [0.03%]
评估呼吸系统疾病患者吸入装置依从性的问卷的更新
Vicente Plaza
Vicente Plaza
Purpose of review: It has been estimated that adherence to inhaled medications in patients with asthma and chronic obstructive pulmonary disease (COPD) is around 50%. This low adherence rate increases morbidity and mortal...
Gustavo J Rodrigo
Gustavo J Rodrigo
Purpose of review: To provide a fast overview about the introduction and development of anticholinergic drugs in Western medicine to their current indications particularly in asthma. ...
Inherited and acquired clinical phenotypes associated with neuroendocrine tumors [0.03%]
与神经内分泌肿瘤相关的遗传和获得性临床表型
Rory E Nicolaides,M Teresa de la Morena
Rory E Nicolaides
Purpose of review: Overview of neuroendocrine neoplasms in the context of their associations with primary and secondary immunodeficiency states. Recent fi...
An update on gain-of-function mutations in primary immunodeficiency diseases [0.03%]
原发性免疫缺陷病中功能获得性突变研究进展
Rekha D Jhamnani,Sergio D Rosenzweig
Rekha D Jhamnani
Purpose of review: Most primary immunodeficiencies described since 1952 were associated with loss-of-function defects. With the advent and popularization of unbiased next-generation sequencing diagnostic approaches follow...
A history into genetic and epigenetic evolution of food tolerance: how humanity rapidly evolved by drinking milk and eating wheat [0.03%]
从遗传和表观遗传进化的角度探究食物耐受性的历史：人类为何以及如何通过饮牛奶食小麦而迅速进化适应
Carine Blanchard
Carine Blanchard
Purpose of review: Human exposure to wheat and milk is almost global worldwide. Yet the introduction of milk and wheat is very recent (5000-10 000 years) when compared to the human evolution. The last 4 decades have seen ...
Critical appraisal of the unmet needs in the treatment of chronic spontaneous urticaria with omalizumab: an Italian perspective [0.03%]
意大利视角下对慢性自发性荨麻疹患者使用奥马珠单抗治疗未尽需求的批判性评估
Riccardo Asero,Giorgio W Canonica,Antonio Cristaudo et al.
Riccardo Asero et al.
Purpose of review: The humanized anti-IgE antibody omalizumab has been available for patients with chronic spontaneous urticaria (CSU) in Italy since 2015. This review summarizes the unresolved issues and unmet therapeuti...
Approaches to the removal of T-lymphocytes to minimize graft-versus-host disease in patients with primary immunodeficiencies who do not have a matched sibling donor [0.03%]
去除T淋巴细胞以减少移植物抗宿主病的发生率——供者为非全合亲缘的原发性免疫缺陷患者行造血干细胞移植时的处理方法
Mary A Slatter,Andrew R Gennery
Mary A Slatter
Purpose of review: Since the advent of T-lymphocyte depletion in hematopoietic stem cell transplantation (HSCT) for primary immunodeficiency, survival following this procedure has remained poor compared to results when us...
Preventing new sensitization and asthma onset by allergen immunotherapy: the current evidence [0.03%]
过敏免疫治疗预防新的过敏和哮喘起病的现有证据
Ulrich Wahn
Ulrich Wahn
Purpose of review: Specific allergen immunotherapy is considered a key candidate for a successful preventive intervention in atopic diseases. The strong association of atopic manifestations such as rhinitis and asthma wit...
Willem van de Veen
Willem van de Veen
Purpose of review: Allergen immunotherapy (AIT) is currently the only curative treatment available for allergic diseases, and has been used in clinical practice for over a century. Induction and maintenance of immune tole...
NLRC4 inflammasomopathies [0.03%]
NLRC4炎症小体病
Neil Romberg,Tiphanie P Vogel,Scott W Canna
Neil Romberg
Purpose of review: The purpose of the review is to highlight developments in autoinflammatory diseases associated with gain-of-function mutations in the gene encoding NLR-family CARD-containing protein 4 (NLRC4), the NLRC...