Ioana Agache,Liliana Rogozea
Ioana Agache
Purpose of review: The precision medicine concept is both appealing and challenging. We review here the recent findings in the endotype-driven approach for major allergic diseases. ...
Assessing the impact of air pollution on childhood asthma morbidity: how, when, and what to do [0.03%]
空气污染对儿童哮喘发病率的影响评估：如何做、何时做以及做什么
Allison J Burbank,David B Peden
Allison J Burbank
Purpose of review: Exposure to air pollutants is linked with poor asthma control in children and represents a potentially modifiable risk factor for impaired lung function, rescue medication use, and increased asthma-rela...
David Fishwick,Steve Forman
David Fishwick
Purpose of review: The outcome for workers with occupational asthma is improved for those with an earlier diagnosis. Health surveillance at work is in principle designed to identify such cases, so that the risks to the in...
Precision medicine in the treatment of primary immunodeficiency diseases [0.03%]
精准医疗在原发性免疫缺陷病治疗中的应用
Jennifer W Leiding,Mark Ballow
Jennifer W Leiding
Purpose of the review: Since the 1990s with the advances in molecular biology, a number of genetic defects have been described. The International Union of Immunological Sciences has recently updated the classification of ...
Cullen M Dutmer,Haejin Kim,Daniel A Searing et al.
Cullen M Dutmer et al.
Purpose of review: Children living in US inner cities experience disparate burdens of asthma, especially in severity, impairment, exacerbations, and morbidity. Investigations seeking to better understand the factors and m...
Louise Fleming
Louise Fleming
Purpose of review: Asthma attacks are frequent in children with asthma and can lead to significant adverse outcomes including time off school, hospital admission and death. Identifying children at risk of an asthma attack...
Silpa D Krefft,Carlyne D Cool,Cecile S Rose
Silpa D Krefft
Purpose of review: Exposure-related bronchiolitis is increasingly recognized as an important but challenging clinical diagnosis. Acute and chronic inhalational exposures are associated with variable clinical presentations...
Development of allergic sensitization and its relevance to paediatric asthma [0.03%]
过敏反应敏感性的发展及其与儿童哮喘的相关性
Ceyda Oksel,Adnan Custovic
Ceyda Oksel
Purpose of review: The purpose of this review is to summarize the recent evidence on the distinct atopic phenotypes and their relationship with childhood asthma. We start by considering definitions and phenotypic classifi...
Elizabeth J Davidson,Ivana V Yang
Elizabeth J Davidson
Purpose of review: Epigenetic marks are emerging as mediators of genetics and the environment on complex disease phenotypes, including childhood asthma and allergy. ...
Levi B Richards,Anne H Neerincx,Job J M H van Bragt et al.
Levi B Richards et al.
Purpose of review: Asthma features a high degree of heterogeneity in both pathophysiology and therapeutic response, resulting in many asthma patients being treated inadequately. Biomarkers indicative of underlying patholo...