The role of regulatory T cells in preventing the development of drug hypersensitivity reactions [0.03%]
调节性T细胞在预防药物过敏反应发生中的作用
Lonnie MacDonald,Megan Mitchell,Paul Thomson
Lonnie MacDonald
Purpose of review: T-cell-mediated drug hypersensitivity reactions represent a major impediment to the drug discovery process whilst presenting a significant burden to the healthcare sector. These reactions are predominan...
Algorithms for the classification of patients with a β-lactam allergy label: a systematic review [0.03%]
β-内酰胺类抗生素过敏患者的分类算法：系统评价
Joana Sousa,Joana Balseiro,Mariana Barreto et al.
Joana Sousa et al.
Purpose of review: Beta-lactam allergy is frequently reported, but only a minority of cases correspond to true allergies. Tools to stratify the risk of a real allergic reaction can possibly help delabeling patients. We ai...
Management of patients with tuberculosis medication-induced drug reaction with eosinophilia and systemic symptoms [0.03%]
结核药物所致药疹型药物反应伴嗜酸性粒细胞增多和系统损害的处理
Jonny Peter,Helen Hoenck,Rannakoe Lehloenya
Jonny Peter
Purpose of review: Tuberculosis (TB) incidence is rising globally, and TB medication-associated drug reaction with eosinophilia and systemic symptoms (DRESS) presents a significant clinical challenge, particularly in peop...
Immune phenotyping impacts on management of severe cutaneous adverse reaction [0.03%]
免疫分型对重症药疹治疗策略的影响
Ryota Hayashi,Riichiro Abe
Ryota Hayashi
Purpose of review: Pathogenesis of severe cutaneous adverse reaction (SCAR) including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome/drug reaction with eosinophi...
Giovanni Costanzo,Valentina Marzio,Edoardo Cavaglià et al.
Giovanni Costanzo et al.
Purpose of review: To provide an accessible, comprehensive overview of past, present, imminent, and future therapies for systemic mastocytosis. Recent fin...
Advancing precision medicine for asthma by focusing on type 2 cytokines and alarmins [0.03%]
聚焦IL-4、IL-13和alarmin信号链，推进哮喘的精准医疗
Remo Poto,Andrea Portacci,Rory Chan et al.
Remo Poto et al.
Purpose of review: Asthma is a heterogeneous disease encompassing distinct phenotypes and endotypes. Advances in elucidating the pathogenic role of type 2 (T2) cytokines and epithelial-derived alarmins have profoundly res...