Kathryn Smiley,Nora Zuhdi,Bob Geng
Kathryn Smiley
Purpose of review: To summarize the effects of type 2 (T2) cytokine-targeting therapies on respiratory infection risk in patients with allergic diseases, with a focus on the interplay between epithelial barrier restoratio...
Gabriele Simonetti,Francesca Mori,Greta Tronconi et al.
Gabriele Simonetti et al.
Purpose of review: While itch is the hallmark symptom of atopic dermatitis (AD), skin pain is increasingly recognized as a common and burdensome symptom even in the pediatric population. Despite its prevalence, pain remai...
Rebekah L Browning,Onyinye I Iweala,Maya R Jerath
Rebekah L Browning
Purpose of review: Alpha-gal syndrome (AGS) is a unique allergy to the carbohydrate galactose-alpha-1,3-galactose, which is found in mammalian products, excluding humans and Old World primates. As its prevalence increases...
Modifying the course of asthma: mechanisms and strategies for clinical remission [0.03%]
哮喘病程的改变：临床缓解的机制和策略
Benedetta Bondi,Diego Bagnasco,Fulvio Braido
Benedetta Bondi
Purpose of review: Asthma management is ongoing a paradigm shift from symptom control and exacerbation prevention toward the more comprehensive goal of clinical remission. This review is timely because biologic therapies,...
Moving towards asthma remission from mechanistic understanding to clinical practice [0.03%]
从机制认识至临床实践促进哮喘缓解
J Christian Virchow,Giovanni Paoletti,Marek Lommatzsch et al.
J Christian Virchow et al.
Purpose of review: In the past, treatment of asthma aimed primarily at "control" of symptoms and a reduction of future risk. Recently, however, the concept of remission has been introduced which is broader than control an...
Crystalline killer: the molecular cascade of silica toxicity from inflammation to fibrosis [0.03%]
结晶杀手：二氧化硅毒性从炎症到纤维化的分子级联反应
Maggie Lam,Michelle D Tate
Maggie Lam
Purpose of review: Silicosis, a progressive fibrotic lung disease caused by inhalation of crystalline silica, is resurging due to increased exposure in high-risk industries such as engineered stone fabrication. Characteri...
Regina Treudler
Regina Treudler
Purpose of review: Occupational anaphylaxis refers to anaphylactic reactions triggered by substances encountered in the workplace. Management of occupational anaphylaxis includes emergency treatment, substitution of elici...
Depemokimab: a new long-acting anti-IL5 treatment for severe asthma and chronic rhinosinusitis with nasal polyps [0.03%]
德普莫单抗：一种治疗重度哮喘和鼻息肉慢性鼻窦炎的新长效抗IL-5疗法
David I Bernstein
David I Bernstein
Purpose of review: Clinical data are reviewed pertaining to depemokimab, the first extended life anti-IL5 mAb, for treating severe eosinophilic asthma. This molecule was engineered through amino acid modification (YTE mut...
Hao Tseng,Robert A Wood
Hao Tseng
Purpose of review: Omalizumab was approved by the U.S. Food and Drug Administration (FDA) to reduce allergic reactions from accidental exposures to food allergens in 2024. This review examines the current state of play in...
Pregnancy complications in women with an inborn error of immunity: a systematic review [0.03%]
遗传性免疫缺陷女性的妊娠并发症：系统评价研究
Bengisu Yakut,Anna C R Knaapen,Xin Yu Cui et al.
Bengisu Yakut et al.
Purpose of review: Many patients with inborn errors of immunity (IEI) reach the reproductive age these days. This systematic review focuses on possible complications during pregnancy in women with IEI. ...