Will precision medicine be available for all patients in the near future? [0.03%]
精准医疗会在不久的将来面向所有患者吗？
René Maximiliano Gómez,Ignacio Ansotegui,Giorgio W Canonica
René Maximiliano Gómez
Purpose of review: Evidence-based medicine and guidelines directing the diagnosis and treatment of patients are changing. General recommendations are moving towards an individual focus, where technology evolution allows i...
Caroline Y Kuo
Caroline Y Kuo
Purpose of review: Conventional gene therapy has been a successful, curative treatment modality for many primary immune deficiencies with significant improvements in the last decade. However, the risk of leukemic transfor...
Emma C Tallantyre,Neil P Robertson,Stephen Jolles
Emma C Tallantyre
Purpose of review: Induction of lymphocyte depletion is increasingly used as a therapeutic strategy for central and peripheral neuroinflammatory disease. However, there is also a growing recognition of the treatment-relat...
William W Busse
William W Busse
Purpose of review: For patients with severe asthma, disease control is not achieved resulting in persistent morbidity and risks for exacerbations. The advent of biologics is providing a new form of treatment for many with...
Vritika Batura,Aleixo M Muise
Vritika Batura
Purpose of review: To summarize the current understanding and recent advances on the genetic aetiology in the pathogenesis of very early onset inflammatory bowel disease (VEO-IBD). ...
Kathleen E Sullivan,Maire Conrad,Judith R Kelsen
Kathleen E Sullivan
Purpose of review: Immune dysregulation disorders are among the most rapidly growing set of inborn errors of immunity. One particular subset is the category where early-onset inflammatory bowel disease (IBD) is the most c...
Mark W Tenn,Matthew Rawls,Anne K Ellis
Mark W Tenn
Purpose of review: The nasal allergen challenge (NAC) model can be a valuable diagnostic tool for allergic rhinitis. Alongside its clinical use, NACs can be used as primary and secondary endpoints in studies evaluating al...
What is new in HIES? Recent insights from the interface of primary immune deficiency and atopy [0.03%]
HIES的新认识：原发性免疫缺陷与特应症界面的最新见解
Mark J Ponsford,William Rae,Adam Klocperk
Mark J Ponsford
Purpose of review: Understanding the pathophysiology of monogenic primary immunodeficiency (PID) with atopic presentation has pivotal implications for intervention strategies and potentially wider polygenic atopic-related...
Carlo Lombardi,Giorgio W Canonica,Giovanni Passalacqua
Carlo Lombardi
Purpose of review: In this review, we sought to outline many of the recent evidences about the available clinical trials in which biologic agents [i.e. omalizumab (OMA)] were associated as add-on to allergen-specific immu...
Yin Yao,Zhi-Chao Wang,Di Yu et al.
Yin Yao et al.
Purpose of review: The discovery of novel T-cell subsets including follicular helper T (Tfh) cells has broadened our knowledge on the complex immune networks in allergic diseases. This review summarizes the evidence for T...