Claudia Crimi,Sebastian Ferri,Nunzio Crimi
Claudia Crimi
Purpose of review: To explore the latest insight of the literature on the asthma/bronchiectasis phenotype providing an updated overview about epidemiological, clinical and biological evidence linking these two conditions....
Michelle C Maciag,Wanda Phipatanakul
Michelle C Maciag
Purpose of review: To describe important precipitants of asthma and allergic disease, to highlight the links between these triggers and modifications within the immune system, and to examine innovative research regarding ...
Peggy S Lai,David C Christiani
Peggy S Lai
Purpose of review: Recent evidence suggests that environmental exposures change the adult human microbiome. Here, we review recent evidence on the impact of the work microbiome and work-related chemical, metal and particu...
Janice A Layhadi,Ibon Eguiluz-Gracia,Mohamed H Shamji
Janice A Layhadi
Purpose of review: Sublingual allergen immunotherapy (SLIT), a disease-modifying treatment for allergic rhinitis, can induce long-term clinical benefits which are mediated by immune responses that include generation of re...
Eugene H Chang
Eugene H Chang
Purpose of review: Surfactant protein-A (SP-A) is a collectin protein expressed in airway epithelia that is critical in the modulation of both innate and adaptive immunity against inhaled pathogens. In this review, we hig...
Obesity and adiposity indicators in asthma and allergic rhinitis in children [0.03%]
哮喘和过敏性鼻炎患儿的肥胖与脂肪指标研究
Hanako Tajima,Ruby Pawankar
Hanako Tajima
Purpose of review: The prevalence of obesity and allergic diseases, such as asthma and allergic rhinitis, is increasing worldwide not only in adults, but also in children. Experimental and clinical studies have demonstrat...
Ichiro Tojima,Takeshi Shimizu
Ichiro Tojima
Purpose of review: Chronic rhinosinusitis (CRS) is a heterogeneous disease and is recently classified into two phenotypes, eosinophilic CRS (ECRS) and non-ECRS. ECRS is characterized by Th2-biased eosinophilic inflammatio...
Helen Clare Ricketts,Douglas C Cowan
Helen Clare Ricketts
Purpose of review: Obese asthma is now widely recognized as a phenotype of difficult asthma that is common and less responsive to traditional asthma treatments, so identifying specific treatments is increasingly important...
Enrico Heffler,Diego Bagnasco,Giorgio W Canonica
Enrico Heffler
Purpose of review: Severe asthmatics, despite the chronic use of high inhaled corticosteroids (ICS) doses and frequent intake of systemic corticosteroids, remains clinically and/or functionally uncontrolled. These patient...
Interleukin-4/interleukin-13 versus interleukin-5: a comparison of molecular targets in biologic therapy for the treatment of severe asthma [0.03%]
白细胞介素-4/白细胞介素-13与白细胞介素-5：重度哮喘生物治疗的分子靶点比较
Albert Y Wu,Sanjiv Sur,J Andrew Grant et al.
Albert Y Wu et al.
Purpose of review: Asthma is a chronic, inflammatory disorder of the airways caused by a complex interplay of various biologic mechanisms. Several monoclonal antibody therapies targeting interleukin (IL)-4/IL-13 and IL-5 ...