Amanda Morgan,Maeve G MacMurdo
Amanda Morgan
Purpose of review: Chronic beryllium disease (CBD) is a granulomatous lung disorder resulting from a cell-mediated immune response to beryllium exposure. Despite exposure regulations, new cases continue to emerge across b...
Markéta Bloomfield,Klára Šabatková,Zuzana Paračková
Markéta Bloomfield
Purpose of review: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is a central conduit linking cytokine signals to immune and tissue homeostasis. Over the past decade, a rapidly expan...
WHIM syndrome: from mechanism to targeted therapy - advances shaping clinical care [0.03%]
WHIM综合征：从发病机制到靶向治疗——影响临床实践的研究进展
Rahim Z Miller,Christoph B Geier,Jacob R Bledsoe et al.
Rahim Z Miller et al.
Purpose of review: Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is an autosomal dominant combined immunodeficiency (CID), often caused by increased CXCR4 pathway signaling. Against early-ons...
Stromal and immune cell interplay promotes neutrophilic inflammation in chronic rhinosinusitis with nasal polyps [0.03%]
间质和免疫细胞互作促进鼻息肉慢性鼻窦炎的中性粒细胞性炎症
Ruo-Yu Lu,Cui-Lian Guo,Zheng Liu
Ruo-Yu Lu
Purpose of review: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disorder, with neutrophilic inflammation representing a clinically challenging endotype due to its resistance to cortico...
Callum Lewandrowski,Brian P Peppers,Chadi A Makary
Callum Lewandrowski
Purpose of review: This review provides the current understanding on primary antibody deficiencies (PAD) in children with chronic rhinosinusitis (CRS). Re...
Update on occupational contact urticaria: a systematic narrative review [0.03%]
职业性接触性荨麻疹的最新研究进展：系统叙述综述
Mojca Bizjak-Suran,Ingrid Løken Jørgensen,Jose Hernán Alfonso
Mojca Bizjak-Suran
Purpose of review: Occupational contact urticaria (OCU) is an immediate-type skin reaction triggered by chemicals or proteins encountered in the workplace. It is classified as either nonimmunologic (irritant) or immunolog...
Ekta Perera,Christopher Codispoti,Mahboobeh Mahdavinia
Ekta Perera
Purpose of review: This review examines how environmental injustice contributes to disparities in allergic diseases, including asthma, allergic rhinitis, and atopic dermatitis. It focuses on the role of social, geographic...
Callan Krevanko,Coralynn Sack
Callan Krevanko
Purpose of review: The expansion of the legal cannabis market has driven rapid, exponential growth in its workforce. Emerging evidence suggests that occupational exposures during cannabis production contribute to respirat...
Environmental exposures, epithelial barrier dysfunction, and the evolving landscape of allergic disorders and asthma [0.03%]
环境暴露、上皮屏障功能障碍与过敏性疾病和哮喘的演变关系
Roman Fenner,Russell A Norris,Anne Maitland
Roman Fenner
Purpose of review: Immediate hypersensitivity disorders, such as asthma, food intolerance, and anaphylaxis, have risen dramatically since the 20th century, marking a shift in the global disease burden. While mast cells ha...
Environmental factors influencing the microbiome in adult asthma: emerging mechanistic insights [0.03%]
成人哮喘中影响微生物组的环境因素：机制见解逐渐阐明
Mário Morais-Almeida,Raquel Baptista-Pestana
Mário Morais-Almeida
Purpose of review: Asthma is a mosaic of phenotypes shaped by complex host-environment interactions. Among these, the microbiome has moved to a central determinant of disease expression, and airway and gut microbiome shou...