Genome-wide association studies in asthma; perhaps, the end of the beginning [0.03%]
哮喘的全基因组关联研究；也许，开始的终结
Gabrielle A Lockett,John W Holloway
Gabrielle A Lockett
Purpose of review: A large number of genetic loci contribute towards an individual's susceptibility to asthma and other complex diseases. Genome-wide association studies (GWASs) have provided us with a wealth of loci asso...
Environmental and genetic contribution in airway epithelial barrier in asthma pathogenesis [0.03%]
哮喘发病机制中环境和遗传因素对气道上皮屏障的贡献
Anne Tsicopoulos,Patricia de Nadai,Corine Glineur
Anne Tsicopoulos
Purpose of review: To examine the recent, most relevant genetic and epigenetic modifications of the epithelial barrier in response to the environmental factors, including allergens, viruses, and pollutants, susceptible to...
Yohan Bossé
Yohan Bossé
Purpose of review: Expression quantitative trait loci (eQTL) mapping studies are the next most important step in genomics to identify susceptibility genes and molecular pathways involved in human diseases following the co...
Shared genetic determinants between eczema and other immune-related diseases [0.03%]
特应性皮炎与其他免疫相关疾病共有的遗传决定因子
Ingo Marenholz,Jorge Esparza-Gordillo,Young-Ae Lee
Ingo Marenholz
Purpose of review: Eczema and other allergic disorders are complex diseases caused by multiple genetic and environmental factors. Here, we review recent success in the identification of novel susceptibility loci for eczem...
Leonard Bielory,Basharut A Syed
Leonard Bielory
Purpose of review: Anterior ocular inflammatory disease (AOID) affects more that 40% of the U.S. population, which includes ocular allergies, various forms of infectious conjunctivitis, and dry eye diseases (tear film dys...
Valérie Gouilleux-Gruart,Nicolas Schleinitz,Alain Fischer
Valérie Gouilleux-Gruart
Management of secondary immune deficiencies: what is the role of immunoglobulins? [0.03%]
次发性免疫缺陷的治疗：免疫球蛋白的作用是什么？
Luc Mouthon,Jean-Paul Fermand,Jacques-Eric Gottenberg
Luc Mouthon
Loïc Guillevin
Loïc Guillevin
Susanne Lau
Susanne Lau
Purpose of review: In the concept of food allergy prevention, no successful strategy could be identified until now. Although interventional trials using probiotics, prebiotics, hydrolyzed formula and bacterial lysates ear...