New insights about the antidepressant-like effects of riparin A in a chronic murine model of depression [0.03%]
关于抑郁症慢性小鼠模型中riparin A抗抑郁作用的新见解
Cássio Prinholato da Silva,Denise Dias Oliveira,Bruno Iglesias Benincasa et al.
Cássio Prinholato da Silva et al.
Riparin A is a synthetic form of natural riparins. Acute scale studies that take into consideration the structure-activity relationship have shown preliminary evidence of antidepressant and anxiolytic effects of riparin A, similar to that a...
D2-like dopamine receptors blockade within the dentate gyrus shows a greater effect on stress-induced analgesia in the tail-flick test compared to D1-like dopamine receptors [0.03%]
与齿状回中D1样多巴胺受体相比，D2样多巴胺受体对热甩尾实验中应激诱导镇痛的影响更大
Homayoon Golmohammadi,Diba Shirmohammadi,Sajad Mazaheri et al.
Homayoon Golmohammadi et al.
Introduction: Acute stress, as a protective mechanism to respond to an aversive stimulus, can often be accompanied by suppressing pain perception via promoting consistent burst firing of dopamine neurons. Besides, sensiti...
Rebecca M Craft
Rebecca M Craft
This study determined whether consumption of a highly palatable liquid is a reliable measure of inflammatory pain and antinociception in male and female rats. After a 10-day acquisition period, the impact of intraplantar oil vs. complete Fr...
Propranolol attenuates the establishment of conditioned context aversions: differential effects compared to MK-801 in an animal model of anticipatory nausea and vomiting [0.03%]
普萘洛尔可减弱条件化情境厌恶的形成：与动物恶心和呕吐预期模型中的MK-801相比的作用差异性研究
Çinar Furkan İlhan,Esra Ülke,Gonzalo P Urcelay et al.
Çinar Furkan İlhan et al.
Cancer patients often experience anticipatory nausea and vomiting (ANV) due to Pavlovian conditioning. Both N-methyl-D-aspartate and beta-adrenergic receptors are known to mediate memory formation, but their role in the development of ANV r...
Comparative Study
Behavioural pharmacology. 2024 Aug 1;35(5):293-302. DOI:10.1097/FBP.0000000000000779 2024
Comparing withdrawal- and anxiety-like behaviors following oral and subcutaneous oxycodone administration in C57BL/6 mice [0.03%]
比较C57BL/6小鼠口服和皮下注射羟考酮后的戒断和焦虑样行为差异
Suzannah S De Almeida,Caryssa R Drinkuth,Gregory C Sartor
Suzannah S De Almeida
Excessive prescribing and misuse of prescription opioids, such as oxycodone, significantly contributed to the current opioid crisis. Although oxycodone is typically consumed orally by humans, parenteral routes of administration have primari...
Comparative Study
Behavioural pharmacology. 2024 Aug 1;35(5):269-279. DOI:10.1097/FBP.0000000000000780 2024
Lawrence M Carey,Saba Ghodrati,Charles P France
Lawrence M Carey
Cannabis is a pharmacologically complex plant consisting of hundreds of potentially active compounds. One class of compounds present in cannabis that has received little attention are terpenes. Traditionally thought to impart aroma and flav...
Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p [0.03%]
姜黄素活性成分藤黄茋通过下调miR-204-3p改善帕金森病模型小鼠症状
Mukaddes Pala,Ismail Meral,Nilgün Pala Acikgoz et al.
Mukaddes Pala et al.
microRNAs (miRNAs) play a significant role in the pathophysiology of Parkinson's disease. In this study, we evaluated the neuroprotective effect of thymoquinone on the expression profiles of miRNA and cognitive functions in the 6-hydroxydop...
Immunization with a low dose of zymosan A confers resistance to depression-like behavior and neuroinflammatory responses in chronically stressed mice [0.03%]
低剂量zymosan A免疫可增强慢性压力小鼠的抗抑郁作用和抗神经炎症作用
Huijun Liu,Tao Zhu,Linlin Zhang et al.
Huijun Liu et al.
Stimulation of the innate immune system prior to stress exposure is a possible strategy to prevent depression under stressful conditions. Based on the innate immune system stimulating activities of zymosan A, we hypothesize that zymosan A m...
NSC689857, an inhibitor of Skp2, produces antidepressant-like effects in mice [0.03%]
NSC689857，一种Skp2抑制剂，产生类似抗抑郁作用的效应
Qingqing Liu,Li Cheng,Fu Li et al.
Qingqing Liu et al.
We have previously reported that two inhibitors of an E3 ligase S-phase kinase-associated protein 2 (Skp2), SMIP004 and C1, have an antidepressant-like effect in non-stressed and chronically stressed mice. This prompted us to ask whether ot...
Prior cocaine self-administration does not impair the ability to delay gratification in rats during diminishing returns [0.03%]
先前的可卡因自给不会影响大鼠在回报递减时延迟满足的能力
H J Pribut,N Kang,Matthew R Roesch
H J Pribut
Previous exposure to drugs of abuse produces impairments in studies of reversal learning, delay discounting and response inhibition tasks. While these studies contribute to the understanding of normal decision-making and how it is impaired ...