Cocaine and d-amphetamine self-administration under a differential reinforcement of low rates schedule of reinforcement in rats [0.03%]
大鼠在不同强化频率下的可卡因和d-安非他明自我给药行为研究
Rachel E Busselman,Kendall Kellerman,Morgan Hamersky et al.
Rachel E Busselman et al.
Stimulant misuse is strongly associated with behavioral impulsivity, including impairments in behavioral inhibition, yet few studies have examined drug self-administration in ways that directly assess inhibitory control. This study aimed to...
Effects of ethanol and nicotine coadministration on probability discounting in rats [0.03%]
乙醇和尼古丁联合使用对大鼠概率折扣的影响
Erin E Wylie,Karen G Anderson
Erin E Wylie
Ethanol and nicotine are among the most widely used drugs in the USA, and their combined use is associated with increased health risks. This study aimed to investigate the acute effects of ethanol alone and in combination with nicotine on r...
Ketamine and crocin exposure modulate anxiety, depression, memory, and pain processes in adolescent female Wistar rats [0.03%]
氯胺酮和藏红花黄对雌性韦斯特大鼠青春期焦虑、抑郁、记忆和疼痛过程的调节作用
Sakineh Alijanpour,Seyed Parsa Golshani,Mohaddeseh Ebrahimi-Ghiri et al.
Sakineh Alijanpour et al.
Ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, and crocin, the bioactive components of Crocus sativus L., affect anxiety, depression, memory, and pain processes. It has not yet been clarified that crocin can potentiate...
Ivermectin: a therapeutic strategy to treat patients with resistant epilepsy [0.03%]
伊维菌素：治疗难治性癫痫的策略
Diana Carolina Ortega,Luis Prieto-Valiente,Arnold H Zea et al.
Diana Carolina Ortega et al.
Drug-resistant epilepsy (DRE) remains a major clinical challenge, with up to one-third of patients experiencing uncontrolled seizures despite polytherapy. Ivermectin (IVM), a macrocyclic lactone with antiparasitic, neuromodulatory, and anti...
Parsing the hypophagic and anxiogenic effects of cocaine in male and female rats [0.03%]
分析可卡因在雄性和雌性大鼠中的厌食和焦虑效应
Karl T Schmidt,Sunil S Das,M Pilar Mengotti Estrada et al.
Karl T Schmidt et al.
Cocaine produces effects including euphoria, local anesthesia, hypophagia/anorexia, and anxiogenesis. The novelty-suppressed feeding (NSF) task is often used as a measure of anxiety-like behavior, except that this task is sensitive to chang...
Xylazine and opioid coadministration enhances stereotyped movements in planarians [0.03%]
苯二氮卓类和阿片类药物联合使用可增强涡虫的刻板运动
Amy D Stringer,Scott M Rawls
Amy D Stringer
Xylazine is a veterinary drug and α2-adrenoceptor agonist that has been increasingly misused as an adulterant in illicit opioids; however, only a few preclinical studies have investigated xylazine's pharmacological profile and impact on op...
5-Hydroxytryptamine 7 receptor agonist LP-211 in combination with gabapentin ameliorates neuropathic pain comorbidities associated with mechanical allodynia in diabetic and nerve-ligated rats [0.03%]
5-HT7受体激动剂LP-211联合加巴喷丁改善糖尿病和神经束扎坐骨神经损伤大鼠机械性异常疼痛共病症状的研究
Venkatesh Goura,Pradeep Jayarajan,Anoop Kishore et al.
Venkatesh Goura et al.
Neuropsychiatric disorders, such as depression and anxiety, are frequently associated with neuropathic pain. Despite the availability of various analgesics, their efficacy in treating neuropathic pain comorbidities has been limited. The aim...
Tsugunobu Andoh,Mami Suzuki,Jung-Bum Lee
Tsugunobu Andoh
In our clinical study, we found that itching had many different expressions (or qualities), including 'muzumuzu' (creepy-crawly itching, somewhat like tickling) and 'itch like mosquito bites'. Therefore, we investigated whether there were b...
Comparison of the hot-plate pain effect between three inhalation methods and subcutaneous injection of heroin [0.03%]
三种吸入方式和皮下注射海洛因热板法致痛效应的比较研究
Yawen Xu,Qinghua Liu,Yuanyuan Chen et al.
Yawen Xu et al.
Heroin, a widely abused opioid, is frequently consumed via inhalation; however, the majority of existing studies have focused on traditional administrations. This study aimed to compare the analgesic effects of heroin across different deliv...
Efficacy and safety of Qudu Huiyuan Pills in the treatment of opioid withdrawal syndrome: a randomized, double-blind, placebo-controlled clinical trial [0.03%]
补阳还五汤治疗戒毒人员阿片类药物戒断症状的有效性及安全性研究：随机、双盲、安慰剂平行对照试验
Jianbiao Xu,Jianhua Bai,Junfeng Wang et al.
Jianbiao Xu et al.
This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of Qudu Huiyuan Pills (QHP), a novel Traditional Chinese Medicine (TCM) formulation, in treating opioid withdrawal syndrome (OWS). The study involved ...