More than an opioid: dissociable analgesic and behavioral effects of kratom in planarians [0.03%]
超越阿片类药物：婆罗门参在扁虫中的镇痛作用和行为效应是可以分离的
Lindsey S Brasfield,Jeff R Kelly,Haley Daugherty et al.
Lindsey S Brasfield et al.
Kratom (Mitragyna speciosa) is a psychoactive plant with stimulant, sedative, and analgesic properties, yet the mechanisms underlying its behavioral effects remain incompletely understood. In particular, it is unclear whether kratom's effec...
Acute glucagon-like peptide-1 receptor agonist, semaglutide, attenuates cue-, drug-, and stress-induced fentanyl seeking in male Sprague-Dawley rats [0.03%]
GLP-1受体激动剂索马鲁肽能减弱Sprague-Dawley大鼠的芬太尼成瘾行为
Brianna Evans,Nikhil Acharya,Christopher G Brandl et al.
Brianna Evans et al.
Opioid overdose deaths continue to be a significant public health problem worldwide, with fentanyl, the primary driver of these losses of life. Indeed, in the USA, overdose deaths continue despite the availability of three food and drug adm...
Delta opioid receptors on parvalbumin cells are necessary for the convulsant and anxiolytic effects of the delta agonist SNC80 [0.03%]
δ阿片受体在parvalbumin细胞中对δ激动剂SNC80的致惊厥和抗焦虑作用是必需的
Marie C Walicki,Matthew R Mueller,Nina Raigosa Garza et al.
Marie C Walicki et al.
The delta opioid receptor (DOR) is expressed broadly throughout the central and peripheral nervous systems. Activation of DOR by exogenous and endogenous ligands regulates pain, motivation, emotion, and memory, but the cells and neural circ...
Psilocybin induces stereotyped movements and reduces defensive responding in planarians through 5-hydroxytryptamine mechanisms [0.03%]
裸露涡虫中通过五羟色胺机制诱发类(ps)精神病行为和减少防御反应
Razeen J Akbar,Amy D Stringer,Sonita Wiah et al.
Razeen J Akbar et al.
Psilocybin is a serotonergic 5-HT2AR agonist that causes psychedelic and anxiolytic effects in human users. To delineate conservation of psilocybin pharmacology, we investigated behavioral effects of psilocybin in planarians (Dugesia doroto...
Determining methamphetamine doses that produce comparable and stable locomotor activity in male and female rats using dose escalation and repeated administration [0.03%]
利用剂量递增和反复给药确定甲基苯丙胺的施用剂量 使雄性和雌性大鼠产生相当且稳定的运动活动反应
Isaac Dickess,Jessica Branford,Hannah R Turner et al.
Isaac Dickess et al.
Biological sex influences sensitivity to the stimulant and toxic effects of methamphetamine (METH) in both humans and rodents, with females exhibiting greater behavioral responsiveness than males. The clinical treatment target of METH-induc...
Announcement of special issue: 'Behavioural pharmacology of ketamine and psychedelic drugs' [0.03%]
专刊介绍:“氯胺酮和迷幻药物的行为药理学”
Bart A Ellenbroek,Gernot Riedel
Bart A Ellenbroek
The 5-HT7 receptor antagonist SB-656104A fails to affect breakpoints for cocaine self-administration in male rats [0.03%]
选择性5-HT7受体拮抗剂SB-656104A对雄性大鼠可卡因自我给药无影响
Serena E Rodarte,Perrin S Steel,Amanda M Acuña et al.
Serena E Rodarte et al.
The availability of efficacious pharmacotherapies for the treatment of cocaine use disorders remains a significant unmet societal need. Cocaine exerts its psychoactive effects primarily by inhibiting presynaptic reuptake of monoamine neurot...
Cecilia Barajas,Lukas D Caye,Parker Jones et al.
Cecilia Barajas et al.
Opioids, including oxycodone, are effective at providing analgesia to patients suffering from pain but carry with them the risk of abuse. Rodent models of self-administration are utilized to evaluate the motivational drive of subjects to se...
Evaluation of scopoletin as a potential therapeutic agent in fibromyalgia: evidence from a reserpine-induced mouse model [0.03%]
斯科ポ林作为纤维肌痛潜在治疗药物的评估：来源于撤可平诱导的小鼠模型证据
Yousra Bseiso,Badriyah S Alotaibi,Alaa A A Aljabali et al.
Yousra Bseiso et al.
Fibromyalgia is a nociplastic pain disorder with musculoskeletal pain. Current treatments are frequently ineffective and produce unwanted side effects. Antinociceptive and neuroprotective activities of scopoletin have not yet been tested in...
Sleep effects of hydrophilic and lipophilic statins: a comparative narrative review of clinical and experimental evidence [0.03%]
他汀类药物的睡眠效应：临床和实验证据的比较叙述性回顾
Sofia Salari,Yasamin Moeinipour,Ghazaleh Elahabadi et al.
Sofia Salari et al.
Statins inhibit 3-hydroxy-3-methylglutaryl CoA reductase to reduce cardiovascular risk, but may induce neuropsychiatric adverse effects. Sleep disturbances, especially insomnia and vivid dreams, are frequently reported, particularly with li...