Evaluation of scopoletin as a potential therapeutic agent in fibromyalgia: evidence from a reserpine-induced mouse model [0.03%]
斯科ポ林作为纤维肌痛潜在治疗药物的评估：来源于撤可平诱导的小鼠模型证据
Yousra Bseiso,Badriyah S Alotaibi,Alaa A A Aljabali et al.
Yousra Bseiso et al.
Fibromyalgia is a nociplastic pain disorder with musculoskeletal pain. Current treatments are frequently ineffective and produce unwanted side effects. Antinociceptive and neuroprotective activities of scopoletin have not yet been tested in...
Sleep effects of hydrophilic and lipophilic statins: a comparative narrative review of clinical and experimental evidence [0.03%]
他汀类药物的睡眠效应：临床和实验证据的比较叙述性回顾
Sofia Salari,Yasamin Moeinipour,Ghazaleh Elahabadi et al.
Sofia Salari et al.
Statins inhibit 3-hydroxy-3-methylglutaryl CoA reductase to reduce cardiovascular risk, but may induce neuropsychiatric adverse effects. Sleep disturbances, especially insomnia and vivid dreams, are frequently reported, particularly with li...
Naltrexone treatment improves anxiety- and depression-like behavior in alcohol-exposed mice [0.03%]
纳曲酮治疗可改善酒精暴露小鼠的类似焦虑和抑郁的行为
Shuangyi Yang,Liang Tong,Le Zhang et al.
Shuangyi Yang et al.
Chronic alcohol exposure threatens central nervous system homeostasis, linking to interconnected dysregulated emotional behavior and robust neuroinflammation. Clinically, individuals with alcohol use disorder (AUD) frequently present comorb...
Microinjection of morphine into the nucleus accumbens and CA1 modulates pain-related behaviors in an animal model of inflammatory pain in male rats [0.03%]
吗啡注射对炎性痛动物模型大鼠疼痛行为的影响及机制研究
Sara Dinparast,Mina Sadeghi,Negar Baharloui et al.
Sara Dinparast et al.
Studies showed that the nucleus accumbens (NAc) and the CA1 of hippocampus involved in multiple functions. Opioid receptors play a critical role in antinociceptive mechanisms. This study explored the involvement of the opioidergic system in...
Wortmannin, a potent phosphatidylinositol 3-kinase inhibitor, suppresses methamphetamine-induced stereotypy and hyperlocomotion in mice [0.03%]
wortmannin通过抑制磷脂酰肌醇3-激酶减轻小鼠安非他明致立体定向行为和超量运动作用的研究
Takahiro Hamana,Nobue Kitanaka,Frank Scott Hall et al.
Takahiro Hamana et al.
Phosphatidylinositol 3-kinase (PI3K) (EC2.7.1.137) is an enzyme essential for a variety of biological processes, including inflammation and neuroplasticity. There is a close, positive relationship between these biological functions and the ...
Prediction model for medication adherence using a medication event monitoring system in recurrent major depressive disorder [0.03%]
基于药物事件监测系统的心境障碍复发再住院患者的用药依从性预测模型研究
Pan Lin,Chunting Hou,Jinjie Ji et al.
Pan Lin et al.
To investigate the risk factors associated with nonadherence to antidepressive drugs in patients with recurrent major depressive disorder (MDD). A total of 847 patients undergoing maintenance treatment for recurrent MDD were prospectively e...
Investigation of p-coumaric acid on intracerebroventricular lipopolysaccharide-induced spatial memory impairment and neuroinflammation in rats [0.03%]
苯甲酰葡萄糖对脑室内注射脂多糖所致大鼠空间记忆损伤及神经炎症的影响研究
Manas Kinra,Madhavan Nampoothiri,Prasada Chowdari Gurram et al.
Manas Kinra et al.
Neuroinflammation mediated by the activation of microglia and subsequent release of proinflammatory cytokines is a key contributor to the pathogenesis of neurodegenerative disorders. In this study, we investigated the neuroprotective effect...
Limited effects of zolmitriptan maintenance on the pharmacodynamic profile of intravenous cocaine in humans [0.03%]
佐米曲普坦维持治疗对人类静脉注射可卡因药理学特征的有限影响
William W Stoops,Joshua A Lile,Joseph L Alcorn rd et al.
William W Stoops et al.
Serotonin 1b (5-HT 1b ) receptors play an important role in preclinical cocaine effects. Zolmitriptan, a commercially available 5-HT 1b / 1d agonist migraine medication, selectively attenuates the reinforcing and other abuse-related effects...
Reinforcing effects of fentanyl/xylazine mixtures in monkeys responding under a food-versus-drug choice procedure [0.03%]
在食物与药物选择情境下分析喷他佐辛和氯胺酮复合物在猴身上的效果增强作用
David R Maguire
David R Maguire
Overdose deaths involving opioids and xylazine, a nonopioid adulterant with sedative, analgesic, and muscle-relaxant properties, have increased dramatically over the past decade. Anecdotal reports suggest xylazine enhances some effects of o...
Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease [0.03%]
硫酸氢甲基硫onium和石南在阿尔茨海默病药理小鼠模型中的效果
Lianne Robinson,Jack Bray,Valeria Melis et al.
Lianne Robinson et al.
The results from clinical trials have indicated that the tau aggregation inhibitor hydromethylthionine mesylate (HMTM) produces disease-modifying effects in Alzheimer's disease (AD) patients when administered alone, but less of an effect wh...