Effects of prenatal cocaine exposure on estrous cycle, and behavior and expression of estrogen receptor alpha and oxytocin during estrus and diestrus in mice offspring [0.03%]
产前接触可卡因对小鼠后代发情周期、雌激素受体α和催产素的行为及表达的影响
Yanghui Zheng,Guangchao Cheng,Xikai Lin et al.
Yanghui Zheng et al.
Increasing evidence indicates that prenatal cocaine exposure may result in many developmental and long-lasting neurological and behavioral effects. The behaviors of female animals are strongly associated with the estrous cycle. Estrogen rec...
Role of l -arginine/nitric oxide/cyclic GMP/K ATP channel signaling pathway and opioid receptors in the antinociceptive effect of rutin in mice [0.03%]
芦丁在小鼠体内的镇痛作用及机制研究：参与信号通路与阿片受体的作用关系研究
Sadaf Fayazzadeh,Sajad Fakhri,Fatemeh Abbaszadeh et al.
Sadaf Fayazzadeh et al.
The l -arginine ( l -Arg)/nitric oxide/cyclic GMP/potassium channel (K ATP ) pathway and opioid receptors are known to play critical roles in pain perception and the antinociceptive effects of various compounds. While there is evidence sugg...
Ultra-low doses of methamphetamine suppress 5-hydroxytryptophan-induced head-twitch response in mice during aging [0.03%]
微量甲基苯丙胺抑制小鼠在衰老过程中5-氢氧色氨酸诱导的摇头反应
Yina Sun,Seetha Chebolu,Nissar A Darmani
Yina Sun
The head-twitch response (HTR) in mice is considered a behavioral assay for activation of 5-HT 2A receptors in rodents. It can be evoked by direct-acting 5-HT 2A receptor agonists such as (±)-2,5-dimethoxy-4-iodoamphetamine, 5-hydroxytrypt...
Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice [0.03%]
里帕林I和II通过调节小鼠星形胶质细胞和小胶质细胞抑制累积应激引起的神经炎症以产生抗抑郁作用
Iardja S L Sales,Alana G de Souza,Adriano J M Chaves Filho et al.
Iardja S L Sales et al.
Depression is a common mood disorder and many patients do not respond to conventional pharmacotherapy or experience a variety of adverse effects. This work proposed that riparin I (RIP I) and riparin II (RIP II) present neuroprotective effe...
Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice [0.03%]
riparin I和riparin II通过调节小胶质细胞在慢性应激诱导的小鼠神经炎症中的抗抑郁作用
Iardja S L Sales,Alana G de Souza,Adriano J M Chaves Filho et al.
Iardja S L Sales et al.
Depression is a common mood disorder and many patients do not respond to conventional pharmacotherapy or experience a variety of adverse effects. This work proposed that riparin I (RIP I) and riparin II (RIP II) present neuroprotective effe...
Evaluation of potential punishing effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rhesus monkeys responding under a choice procedure [0.03%]
评估2,5二甲氧基-4-甲胺苯(DOM)在雄性恒河猴选择程序应对中的潜在惩罚效果
David R Maguire
David R Maguire
Objectives: There has been substantial and growing interest in the therapeutic utility of drugs acting at serotonin 2A subtype (5-HT 2A ) receptors, increasing the need for characterization of potential beneficial and adv...
Antidepressive synergism between crocin and D-AP5 in acute restraint-stressed mice [0.03%]
丙酮酸氨基氮杂环戊烯和藏红花素对急性束缚应激小鼠的抗抑郁协同作用
Sana-Sadat Gerami,Mohaddeseh Ebrahimi-Ghiri,Fatemeh Khakpai et al.
Sana-Sadat Gerami et al.
Emerging evidence suggests that crocin rescues stress-induced depressive symptoms in mice via stimulation of hippocampal neurogenesis. Glutamate modulators mainly involving N-methyl- d -aspartate (NMDA) receptors (NMDARs) have highlighted a...
Stimulation of central histaminergic transmission attenuates diazepam-induced motor disturbance on rota-rod and beam walking tests in mice [0.03%]
中枢组胺能传递的刺激可缓解地西泮致小鼠旋转棒和平衡木运动障碍作用
Richa Patel,Nishant Sudhir Jain
Richa Patel
Diazepam administration has been shown to influence the release of histamine in various brain areas involved in motor behavior. Therefore, the present study explored the plausible regulatory role of the central histaminergic system in diaze...
Antidepressant effect of PT-31, an α₂-adrenoceptor agonist, on lipopolysaccharide-induced depressive-like behavior in mice [0.03%]
PT-31抗抑郁作用研究及其对脂多糖所致小鼠类似抑郁行为的影响
Juliana Machado Kayser,Fernanda Petry,Maryelen Alijar Souza et al.
Juliana Machado Kayser et al.
Increasing evidence indicates that neuroinflammation, oxidative stress, and neurotrophic factors play a key role in the pathophysiology of major depressive disorder (MDD). In addition, the attenuation of inflammatory response has been consi...
A novel tramadol-polycaprolactone implant could palliate heroin conditioned place preference and withdrawal in rats: behavioral and neurochemical study [0.03%]
一项关于tramadol-聚己内酯植入剂可缓解大鼠海洛因条件位置偏爱和戒断的行为学和神经化学研究的新研究
Shaimaa A Elshebiney,Rania A Elgohary,Marwa E El-Shamarka et al.
Shaimaa A Elshebiney et al.
Drug dependence is a chronic brain disease characterized by craving and recurrent episodes of relapse. Tramadol HCl is a promising agent for withdrawal symptoms management, considering its relatively low abuse potential and safety. Oral adm...