Assessing acute effects of methylphenidate and modafinil on inhibitory capacity, time estimation, attentional lapses, and compulsive-like behavior in rats [0.03%]
甲基苯环丙胺和莫达非尼对大鼠抑制能力、时间估计、注意力缺失和类似强迫行为的急性影响评估
Rodrigo Sosa,Pedro Espinosa-Villafranca,Pablo Saavedra et al.
Rodrigo Sosa et al.
Medications known as 'cognitive enhancers' are increasingly being consumed off-label by healthy people, raising concerns about their safety. The aim of our study was to profile behavioral performance upon oral administration of methylphenid...
The effects of xylazine on locomotion and motor behaviour in a planarian model [0.03%]
丁丙诺啡对扁形动物运动和行为影响的模型研究
Ryan Taylor,Eric Denette,Ellie Walter-Goodspeed et al.
Ryan Taylor et al.
In recent years, the recreational use of xylazine has increased dramatically in the USA. Although xylazine has been used as an anesthetic in veterinary medicine for decades, little is known about its behavioral effects. We took advantage of...
Morphine-induced side effects can be differentially modulated by cannabidiol in male and female rats [0.03%]
大麻二酚可差异调节吗啡在雄性与雌性大鼠中的副作用
Carlos Henrique Alves Jesus,Jaqueline Volpe,Bruna Bittencourt Sotomaior et al.
Carlos Henrique Alves Jesus et al.
Opioid use disorder is a public health problem that includes symptoms such as withdrawal syndrome and opioid-induced hyperalgesia. Currently, drugs to treat side effects of opioids also have undesirable effects, which lead to limitations. T...
Role of D1- and D2-like dopamine receptors within the CA1 hippocampal region in the stress-induced antinociceptive response in the exposure to acute pain [0.03%]
D1型和D2样多巴胺受体在急性疼痛暴露下作用于海马CA1区区域的应激引起的抗痛反应中的作用研究
Diba Shirmohammadi,Homayoon Golmohammadi,Fatemehsadat Seyedaghamiri et al.
Diba Shirmohammadi et al.
Exposure to stressful conditions such as forced swim stress (FSS) induces antinociception. Previous reports determined that dopamine receptors in the CA1 hippocampal area are important in chronic pain processing. Considering that neural mec...
Posttraumatic anxiety-like behaviour in zebrafish is dose-dependently attenuated by the alpha-2A receptor agonist, guanfacine [0.03%]
多剂量氯化锂处理对斑马鱼电休克后焦虑行为的影响及其机制研究
Cailin van Staden,David Weinshenker,Karin Finger-Baier et al.
Cailin van Staden et al.
Traumatic stress exposure increases noradrenaline (NA) release, which contributes to anxiety and impaired risk-appraisal. Guanfacine, a selective alpha-2A adrenergic receptor agonist, has been used to treat stress-related disorders characte...
Effect of acute treatment with the glucagon-like peptide-1 receptor agonist, liraglutide, and estrus phase on cue- and drug-induced fentanyl seeking in female rats [0.03%]
胰高血糖素样肽-1受体激动剂利拉格列汀的急性处理和发情期对雌性大鼠吗啡寻取的影响
Luke A Urbanik,Jennifer L Booth,Nikhil K Acharya et al.
Luke A Urbanik et al.
Opioid use disorder (OUD) is a crisis in the USA. Despite advances with medications for OUD, overdose deaths have continued to rise and are largely driven by fentanyl. We have previously found that male rats readily self-administer fentanyl...
Danielle Nykanen,Hannah Stiffler,Merrick Bay et al.
Danielle Nykanen et al.
Recent evidence suggests that cannabis can impair simple auditory processes, and these alterations might be due to cannabinoid agonism. The effect of cannabinoid agonism on relatively complex processes such as auditory discrimination is unk...
The antidepressant-like activity of ketamine in the rat chronic mild stress model requires activation of cortical 5-HT1A receptors [0.03%]
氯胺酮在慢性轻度脑部模型中的抗抑郁作用需要激活皮层五-羟色胺受体
Ronan Depoortère,Mariusz Papp,Piotr Gruca et al.
Ronan Depoortère et al.
Ketamine displays efficacious rapid-acting antidepressant (RAAD) activity in the rat chronic mild stress (CMS) model. It rapidly reverses anhedonia (CMS-induced sucrose consumption deficit) and attenuates working memory deficit (novel objec...
1,4-dihydroxy-2-naphthoic acid prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced motor function deficits [0.03%]
1,4-二羟基-2-萘甲酸预防1-甲基-4-苯基-1,2,3,6-四氢吡啶致运动功能缺损
Caitlin A Madison,Roanna A Debler,Paula L Gallegos et al.
Caitlin A Madison et al.
Parkinson's disease (PD), characterized by death of dopaminergic neurons in the substantia nigra, is the second most prevalent progressive neurodegenerative disease. However, the etiology of PD is largely elusive. This study employed the 1-...
Age is associated with altered locomotor and hypothermic response to acute nicotine [0.03%]
年龄与急性尼古丁致动物运动和产热反应改变有关
Carlos Novoa,Prescilla Garcia-Trevizo,Thomas J Gould
Carlos Novoa
Cigarette smoking is at an all-time low. However, nicotine consumption has diversified with the introduction of commercial tobacco products that include Electronic Nicotine Delivery Systems. Nicotine is the main psychoactive component of to...