Using UAS-Gal4 designer receptors exclusively activated by designer drugs to elucidate nondopaminergic modulation of methamphetamine-induced locomotion in Drosophila [0.03%]
采用仅用设计药物激活的UAS-Gal4设计师受体揭示Drosophila中甲基苯丙胺诱导运动的非多巴胺能调节作用
Meghan Hibicke,Charles D Nichols
Meghan Hibicke
Methamphetamine (METH) use disorder is a serious public health problem with no Food and Drug Administration-approved therapeutic drugs to aid recovery. METH's primary mechanism of action increases dopaminergic neurotransmission in brain reg...
Effects of three tryptamines: alpha-methyltryptamine, 5-methoxy-alpha-methyltryptamine, and 5-methoxy-N,N-diisopropyltryptamine on acute toxicity, locomotor activity, and hallucinogenic behavior in mice [0.03%]
三种色胺：α-甲基色胺、5-甲氧基-α-甲基色胺和5-甲氧基-N，N-二异丙基色胺对急性毒性、运动活动和幻觉行为的影响
Kaixi Li,Nan Li,Yuanyuan Chen et al.
Kaixi Li et al.
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are synthetic tryptamines with hallucinogenic-like properties that are widely abused worldwide. There, however,...
Unveiling the anti-inflammatory and antinociceptive effects of limonene in two models of carrageenan-induced inflammation and formalin-induced pain: role of l-arginine/nitric oxide/cGMP/KATP channel signaling pathways, opioidergic, and benzodiazepine receptors [0.03%]
探讨D-柠檬烯抗炎及镇痛作用：在两种卡拉胶诱导的炎症和福尔马林致痛模型中的作用机制以及L-精氨酸/一氧化氮/cGMP/KATP通道信号通路、阿片受体和苯二氮卓受体的作用
Sajad Fakhri,Mostafa Yarmohammadi,Fatemeh Abbaszadeh et al.
Sajad Fakhri et al.
Pain and inflammation are critical and complex biological responses to tissue damage or disease, which significantly impair life quality. The complex pathophysiological mechanisms highlight the necessity for multitarget therapeutic interven...
Procognitive effects of methyl 2-amino-3-methoxybenzoate (or daopine) may involve the dorsal striatal anthranilic acid pathway and mutimetabolite-multitarget pharmacology [0.03%]
甲基2-氨基-3-甲氧苯甲酸（或daopine）的促认知作用可能涉及背侧纹状体抗坏血酸通路和多重代谢产物-多重靶标药物学
Yami Bright,Helene I V Amatdjais-Groenen,Michel M M Verheij et al.
Yami Bright et al.
Multifunctional drug treatment is currently the most promising approach in neuropsychopharmacology to overcome complex disorders, such as schizophrenia. We previously showed that the natural protoalkaloid, methyl 2-amino-3-methoxybenzoate [...
Effect of Alcea aucheri (Bioss.) Alef extract against scopolamine-induced memory impairment in rats [0.03%]
阿尔塞斯提取物对丁公藤诱发的大鼠记忆损伤的影响作用研究
Tajmah Mombeini,Hamid Gholami Pourbadie,Mohammad Kamalinejad et al.
Tajmah Mombeini et al.
Memory impairment is a core feature of neurodegenerative diseases such as Alzheimer's disease, often modeled using scopolamine-induced cognitive dysfunction in animals. While Alcea aucheri (Boiss.) Alef has demonstrated anxiolytic propertie...
Pirfenidone alone or combined with either dulaglutide or empagliflozin protects against fructose-induced Parkinsonian features in rats [0.03%]
吡非尼酮单独或联合杜拉鲁肽或恩格列净对保护弗鲁糖诱导的帕金森病特征的作用
Alaa S Wahba,Hoda E Mohamad,Dina M Abo-Elmatty et al.
Alaa S Wahba et al.
This study aimed to investigate and characterize Parkinson's-like behavioral, histological, and biochemical changes induced by feeding fructose (10% w/v) for 24 weeks in rats. Additionally, we aimed to evaluate the potential protective effe...
Cannabidiol and cognition: a literature review of human randomized controlled trials [0.03%]
大麻二酚与认知：人体随机对照试验的文献回顾
Jyotpal Singh,Chase J Ellingson,M Abdullah Shafiq et al.
Jyotpal Singh et al.
Cannabidiol (CBD) is a phytocannabinoid without intoxicating properties. While CBD can improve neurophysiological functions and subjective symptoms, its effect on cognitive function remains unclear. We summarized the available randomized co...
Role of serotonin 5HT2C receptors in the discriminative stimulus properties of lorcaserin in male C57BL/6 mice [0.03%]
五氯卡塞宁在雄性C57BL/6小鼠上辨别刺激作用中的五-羟色胺2C受体的作用研究
Fan Zhang,Katherine L Nicholson,Keith L Shelton et al.
Fan Zhang et al.
The serotonin 2C receptor (5-HT2C) has been investigated as a potential therapeutic target for a variety of psychiatric disorders, as well as the treatment of obesity. A stumbling block in the development of these medications is identifying...
Neurobehavioral manifestations in female rats after intermittent exposure to an anticancer agent, paclitaxel [0.03%]
间断接触抗肿瘤药物紫杉醇后雌性大鼠的神经行为表现
Deepika Pathak,K P Singh
Deepika Pathak
Paclitaxel (PTX), a widely used chemotherapeutic agent, causes both peripheral and central neurotoxicity, leading to significant behavioral impairments. However, inadequate literature is available on PTX-induced neurobehavioral sequelae ass...