Curcumin mitigates memory deficits induced by subcutaneous aluminum nanoparticle administration through modulation of hippocampal brain-derived neurotrophic factor and Akt signaling pathways [0.03%]
姜黄素通过调节海马脑源性神经营养因子和Akt信号通路来缓解皮下注射铝纳米颗粒诱导的记忆力减退
Samaneh Reiszadeh Jahromi,Zahra Keikhosravi,Roksana SoukhakLari et al.
Samaneh Reiszadeh Jahromi et al.
Research has indicated a strong link between exposure to aluminum (Al) and the development of Alzheimer's disease (AD). Given the rising use of Al nanoparticles, which are far more neurotoxic than Al, it is noteworthy to investigate the pos...
Gabapentin and D-cycloserine alone and in combination with naloxone in methadone-maintained humans responding under a naloxone novel-response discrimination procedure [0.03%]
加巴喷丁和D-环丝氨酸与纳洛酮联用或不与之联用对正在接受美沙酮维持治疗且处于新型反应辨别程序下的人体的作用效果研究
Lauren R Fitzgerald,Nichole C Stanley,Joseph B Guise et al.
Lauren R Fitzgerald et al.
The present study examined the impact of the N-type calcium channel blocker gabapentin (GBP) and the partial glycine agonist D-cycloserine (CYC) to attenuate the behavioral effects of naloxone in opioid-dependent humans responding under a n...
Slight and hidden hearing loss differentially affect short- and long-term memory in young rats [0.03%]
轻度和隐性听力损失对年轻大鼠短期记忆和长期记忆的不同影响
Joëlle D Jagersma,Sonja J Pyott,Jocelien D A Olivier
Joëlle D Jagersma
Mild forms of hearing loss (HL) have been linked to cognitive impairments in children, yet the neurobiological mechanisms underlying this connection remain unclear. Existing research using animal models mostly focuses on more severe levels ...
Mariangel Varela,Charlotte C Gard,Wiebke J Boeing
Mariangel Varela
Cannabidiol (CBD) was first isolated in the 1940s and its drug structure was established in the 1960s. It has risen significantly in popularity since then and has been observed to reduce inflammation and anxiety in patients. CBD is easy to ...
Self-synergy antinociceptive effect of diclofenac: effect of peripheral inhibition of nitric oxide synthase [0.03%]
硝酸盐合酶周围外抑制对氯酚唪自协同抗止痛作用的影响
Jorge Elías Torres-López,Mayra Martínez-Martínez,Leonor Ivonne Parra-Flores
Jorge Elías Torres-López
This study was conducted to characterize the interaction between the systemic and local peripheral antinociceptive effect of diclofenac, a nonsteroidal anti-inflammatory drug. As well as the effect of local peripheral administration of NG-n...
Investigating the effects of different herbal preparations, 5-hydroxytryptophan and involuntary exercise on affective bias modification in male Lister Hooded rats [0.03%]
不同草药制剂、5-羟色氨酸和非自主运动对雄性威斯特大鼠情绪偏好的影响研究
Justyna K Hinchcliffe,Sarah A Stuart,Emma S J Robinson
Justyna K Hinchcliffe
Mood disorders are a prevalent global health concern with natural health products, including herbal supplements, an increasingly popular choice as an alternative or complementary therapy. Despite their widespread use, few studies have teste...
Theobromine synergizes with nicotine to enhance animal motor abilities and cognitive function [0.03%]
可可碱与尼古丁协同作用以增强动物的运动能力和认知功能
Wenjuan Zhang,Xiao Yang,Baojiang He et al.
Wenjuan Zhang et al.
The societal consensus on the need for smoking cessation is well-established, yet the number of tobacco users continues to rise. This trend is largely driven by the potent physiological effects of nicotine, which significantly increase the ...
Leptin-dopamine interactions: unveiling the common link between type-2 diabetes and neuropsychiatric comorbidities [0.03%]
leptin与多巴胺的相互作用：揭开2型糖尿病和神经精神共病之间的共同联系
Allyson Gill,Madison Gill,Rahul Mittal et al.
Allyson Gill et al.
Clinical evidence highlights the central nervous system as a key target in type-2 diabetes-related complications, yet the mechanisms underlying the increased prevalence of mood disorder issues, mainly depression, in patients with diabetes r...
The effect of Psilocybe cubensis alkaloids on depressive-like behavior in mice exposed to maternal separation with respect to hippocampal gene expression and DNA methylation of Slc6a4 and Nr3c1 [0.03%]
不同种Psilocybe 立方体碱对与海马基因表达和Slc6a4和Nr3c1的DNA甲基化有关的分离抑郁小鼠行为的影响
Eghbal Jasemi,Ali Razmi,Salar Vaseghi et al.
Eghbal Jasemi et al.
Maternal separation as an early life stress can lead to long-lasting deleterious effects on cognitive and behavioral functions, and the mood state. On the other hand, Psilocybe cubensis (as one of the most well-known magic mushrooms) may be...
Priya Mullassaril,Lucy Brodkin,Jesse Brodkin
Priya Mullassaril
This study aimed to determine whether the second-generation cannabinoid receptor subtype 1 (CB1) antagonist, monlunabant - designed to treat obesity by targeting peripheral receptors - might actually exert its effects through CB1 receptors ...