Unveiling the anti-inflammatory and antinociceptive effects of limonene in two models of carrageenan-induced inflammation and formalin-induced pain: role of l-arginine/nitric oxide/cGMP/KATP channel signaling pathways, opioidergic, and benzodiazepine receptors [0.03%]
探讨D-柠檬烯抗炎及镇痛作用：在两种卡拉胶诱导的炎症和福尔马林致痛模型中的作用机制以及L-精氨酸/一氧化氮/cGMP/KATP通道信号通路、阿片受体和苯二氮卓受体的作用
Sajad Fakhri,Mostafa Yarmohammadi,Fatemeh Abbaszadeh et al.
Sajad Fakhri et al.
Pain and inflammation are critical and complex biological responses to tissue damage or disease, which significantly impair life quality. The complex pathophysiological mechanisms highlight the necessity for multitarget therapeutic interven...
Procognitive effects of methyl 2-amino-3-methoxybenzoate (or daopine) may involve the dorsal striatal anthranilic acid pathway and mutimetabolite-multitarget pharmacology [0.03%]
甲基2-氨基-3-甲氧苯甲酸（或daopine）的促认知作用可能涉及背侧纹状体抗坏血酸通路和多重代谢产物-多重靶标药物学
Yami Bright,Helene I V Amatdjais-Groenen,Michel M M Verheij et al.
Yami Bright et al.
Multifunctional drug treatment is currently the most promising approach in neuropsychopharmacology to overcome complex disorders, such as schizophrenia. We previously showed that the natural protoalkaloid, methyl 2-amino-3-methoxybenzoate [...
Effect of Alcea aucheri (Bioss.) Alef extract against scopolamine-induced memory impairment in rats [0.03%]
阿尔塞斯提取物对丁公藤诱发的大鼠记忆损伤的影响作用研究
Tajmah Mombeini,Hamid Gholami Pourbadie,Mohammad Kamalinejad et al.
Tajmah Mombeini et al.
Memory impairment is a core feature of neurodegenerative diseases such as Alzheimer's disease, often modeled using scopolamine-induced cognitive dysfunction in animals. While Alcea aucheri (Boiss.) Alef has demonstrated anxiolytic propertie...
Pirfenidone alone or combined with either dulaglutide or empagliflozin protects against fructose-induced Parkinsonian features in rats [0.03%]
吡非尼酮单独或联合杜拉鲁肽或恩格列净对保护弗鲁糖诱导的帕金森病特征的作用
Alaa S Wahba,Hoda E Mohamad,Dina M Abo-Elmatty et al.
Alaa S Wahba et al.
This study aimed to investigate and characterize Parkinson's-like behavioral, histological, and biochemical changes induced by feeding fructose (10% w/v) for 24 weeks in rats. Additionally, we aimed to evaluate the potential protective effe...
Cannabidiol and cognition: a literature review of human randomized controlled trials [0.03%]
大麻二酚与认知：人体随机对照试验的文献回顾
Jyotpal Singh,Chase J Ellingson,M Abdullah Shafiq et al.
Jyotpal Singh et al.
Cannabidiol (CBD) is a phytocannabinoid without intoxicating properties. While CBD can improve neurophysiological functions and subjective symptoms, its effect on cognitive function remains unclear. We summarized the available randomized co...
Role of serotonin 5HT2C receptors in the discriminative stimulus properties of lorcaserin in male C57BL/6 mice [0.03%]
五氯卡塞宁在雄性C57BL/6小鼠上辨别刺激作用中的五-羟色胺2C受体的作用研究
Fan Zhang,Katherine L Nicholson,Keith L Shelton et al.
Fan Zhang et al.
The serotonin 2C receptor (5-HT2C) has been investigated as a potential therapeutic target for a variety of psychiatric disorders, as well as the treatment of obesity. A stumbling block in the development of these medications is identifying...
Neurobehavioral manifestations in female rats after intermittent exposure to an anticancer agent, paclitaxel [0.03%]
间断接触抗肿瘤药物紫杉醇后雌性大鼠的神经行为表现
Deepika Pathak,K P Singh
Deepika Pathak
Paclitaxel (PTX), a widely used chemotherapeutic agent, causes both peripheral and central neurotoxicity, leading to significant behavioral impairments. However, inadequate literature is available on PTX-induced neurobehavioral sequelae ass...
5-HT2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats [0.03%]
五羟色胺2A受体拮抗剂可减轻大鼠的阿片类药物戒断综合征及其厌恶反应
Ping-Hsun Tsai,Erica R Morales,Yvonne Y Reed et al.
Ping-Hsun Tsai et al.
This study explored a potential role for the 5-hydroxytryptamine2A (5-HT2A) serotonin receptor in opiate physical dependence. Rats were rendered opiate-dependent by 7 days of continuous subcutaneous (s.c.) morphine sulfate infusion. Pimavan...
Deciphering the antinociceptive and anti-inflammatory effects of pelargonidin through L-arginine/nitric oxide/cyclic GMP/ATP-sensitive potassium channel signaling pathway and gamma-aminobutyric acid/opioidergic receptors [0.03%]
通过L-精氨酸/一氧化氮/环鸟苷酸/腺苷酸调激酶通道信号通路和γ氨基丁酸/阿片受体解读花青素pelargonidin的镇痛和抗炎作用
Sona Hamidi,Fatemeh Abbaszadeh,Amir Kiani et al.
Sona Hamidi et al.
There are complex dysregulated pathways behind the pathogenesis of pain and inflammation. Because most of the present drugs have certain side effects or are not effective enough, providing novel multitargeting and potent therapeutic agents ...