Valproic acid triggers a sex-independent autism-like deficits, gut-brain axis, and neurodegenerative changes in the autism model of Wistar rats [0.03%]
戊酸盐诱导孤独症模型大鼠出现性别无关的自闭症缺陷、脑肠轴改变及神经退行性变化
Ashish Jain,Neha Dhir,Amit Raj Sharma et al.
Ashish Jain et al.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in social interaction, communication, restricted interests, and repetitive behaviors. Its higher prevalence in males underscores the importan...
Gut-brain axis and depression: focus on the amino acid and short-chain fatty acid metabolism [0.03%]
肠-脑轴与抑郁症：氨基ogenesis及短链脂肪酸代谢的研究焦点
Mengjing Chen,Qiuju Lyu,Lina Huang et al.
Mengjing Chen et al.
Depression, a major psychiatric disorder with profound societal impact, remains incompletely understood in its etiology. Identifying novel pathogenic pathways is therefore essential. The gut microbiota ('second brain') critically regulates ...
Prevention of morphine dependence with a combination of ketotifen and l-carnitine in mice: a new potential therapeutic approach [0.03%]
一种可以预防小鼠吗啡依赖的酮替芬和左旋肉碱联合疗法：新的潜在治疗手段
Bohloul Habibi Asl,Solmaz Fallahi,Sanam Bohlouli et al.
Bohloul Habibi Asl et al.
Morphine dependence is a complex clinical issue, coinciding with oxidative stress and increased neurotransmitter levels as key factors in this drug's reliance and tolerance. This study examines how l-carnitine, ketotifen, and their combinat...
Synbiotic diet produces antidepressant-like effects but alters ketamine activity in an avian model of treatment-resistant depression [0.03%]
合成益生菌饮食产生类似抗抑郁的作用，但会改变凯那明的活性：一种难治性抑郁症禽类模型中的作用研究
Stephen W White,Tara D Clover,Kenneth J Sufka
Stephen W White
Pre- and probiotics promote a diverse and functional gut microbiota and have demonstrated both anxiolytic and antidepressant effects; however, how synbiotic diet interacts with antidepressant medications has not been fully investigated. Thi...
Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk [0.03%]
化学线索指示捕食风险下盐酸地西泮对特立尼达剑尾鱼焦虑行为的影响研究
Adam L Crane,Laurence E A Feyten,Alix J P Brusseau et al.
Adam L Crane et al.
The fear of predation is pervasive among vertebrate prey species, being characterized by neurobiological and behavioral changes induced by risk exposure. To understand the acquisition and attenuation of fearful phenotypes, such as dimension...
The effect of lithium on behavioral functions in adolescent rats exposed to chronic unpredictable mild stress with respect to brain-derived neurotrophic factor and glycogen synthase kinase-3 beta levels in the prefrontal cortex [0.03%]
锂对慢性轻度不可预测应激下大鼠行为功能的影响及与海马脑源性神经营养因子和糖原合成酶激酶-β的关系研究
Maryam Abbasi Mehmandost Sofla,Mahdie Gholami,Salar Vaseghi et al.
Maryam Abbasi Mehmandost Sofla et al.
Chronic unpredictable mild stress (CUMS) is widely used as a reliable method to induce depressive states and anhedonia in rodents. Lithium is one of the well-known drugs used for the alleviation of symptoms in different neuropsychiatric dis...
Antidepressant effect or bias? Systematic review and meta-analysis of studies using the forced swimming test [0.03%]
抗抑郁作用还是偏倚？使用强迫游泳法研究的系统评价和荟萃分析
Tamires Martins,Ana B Ramos-Hryb,Marcus Antonio B da Silva et al.
Tamires Martins et al.
The forced swim test (FST) assesses antidepressant activity in rodents by measuring suppression of immobility. This study reviewed the literature to evaluate how experimental conditions, study quality, and bias influence antidepressant effi...
Resveratrol improves ovariectomy and chronic restraint stress-induced depression-like behaviors in mice through brain-derived neurotrophic factor associated structural synaptic remodeling [0.03%]
白藜芦醇通过脑源性神经营养因子相关结构突触重塑改善卵巢切除和慢性束缚应激诱导的小鼠抑郁样行为
Hui Xu,Zhen-Qiang Zhang,Geng Chen et al.
Hui Xu et al.
Previous studies have shown that resveratrol has antidepressant effects in a variety of depression models, but the effect and mechanism of resveratrol on menopausal depression are unclear. In this study, transgenic mice were ovariectomized ...
Using UAS-Gal4 designer receptors exclusively activated by designer drugs to elucidate nondopaminergic modulation of methamphetamine-induced locomotion in Drosophila [0.03%]
采用仅用设计药物激活的UAS-Gal4设计师受体揭示Drosophila中甲基苯丙胺诱导运动的非多巴胺能调节作用
Meghan Hibicke,Charles D Nichols
Meghan Hibicke
Methamphetamine (METH) use disorder is a serious public health problem with no Food and Drug Administration-approved therapeutic drugs to aid recovery. METH's primary mechanism of action increases dopaminergic neurotransmission in brain reg...
Effects of three tryptamines: alpha-methyltryptamine, 5-methoxy-alpha-methyltryptamine, and 5-methoxy-N,N-diisopropyltryptamine on acute toxicity, locomotor activity, and hallucinogenic behavior in mice [0.03%]
三种色胺：α-甲基色胺、5-甲氧基-α-甲基色胺和5-甲氧基-N，N-二异丙基色胺对急性毒性、运动活动和幻觉行为的影响
Kaixi Li,Nan Li,Yuanyuan Chen et al.
Kaixi Li et al.
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are synthetic tryptamines with hallucinogenic-like properties that are widely abused worldwide. There, however,...