Pretreatment with LY2090314, a potent glycogen synthase kinase-3 inhibitor, suppresses methamphetamine-induced stereotyped behavior but not hyperlocomotion in mice [0.03%]
glycogen合成酶激酶-3抑制剂LY2090314预处理可减轻小鼠的甲基苯丙胺诱导的刻板行为但不影响多动行为
Kentaro Matsuda,Nobue Kitanaka,Frank Scott Hall et al.
Kentaro Matsuda et al.
Neuronal glycogen synthase kinase-3s (GSK-3α and the more abundant GSK-3β) are serine/threonine kinases that have been postulated to play roles in neuronal adaptations, including those that come from exposures to substances of abuse; howe...
Psilocybin inhibits formalin-induced nociception through 5-hydroxytryptamine 2A receptor in rats [0.03%]
裸头大鼠模型中psilocybin通过5-羟色胺2A受体抑制甲醛所致的疼痛反应
Saadet Inan,Paige Morris,Scott M Rawls et al.
Saadet Inan et al.
Psilocybin is found in a family of mushrooms commonly known as Psilocybe. We aimed to study the antinociceptive efficacy of psilocybin using formalin-induced noxious stimuli, a model that comprises both acute and persistent pain in rats. Ad...
Gut-brain axis and depression: focus on the amino acid and short-chain fatty acid metabolism [0.03%]
肠-脑轴与抑郁症关联：氨基酸和短链脂肪酸代谢的新焦点
Mengjing Chen,Qiuju Lyu,Lina Huang et al.
Mengjing Chen et al.
Depression, a major psychiatric disorder with profound societal impact, remains incompletely understood in its etiology. Identifying novel pathogenic pathways is therefore essential. The gut microbiota ('second brain') critically regulates ...
Valproic acid triggers a sex-independent autism-like deficits, gut-brain axis, and neurodegenerative changes in the autism model of Wistar rats [0.03%]
戊酸盐诱导Wistar大鼠自闭症模型中的性别无关的自闭症样缺陷、脑-肠轴改变和神经退行性变化
Ashish Jain,Neha Dhir,Amit Raj Sharma et al.
Ashish Jain et al.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in social interaction, communication, restricted interests, and repetitive behaviors. Its higher prevalence in males underscores the importan...
Haloperidol potentates the antinociceptive effect of buprenorphine and tramadol in rats [0.03%]
氟哌啶醇增强氯胺酮和右美沙芬的镇痛作用研究
Rolffy Ortiz-Andrade,Lilian Dolores Chel-Guerrero,Myrna Déciga-Campos
Rolffy Ortiz-Andrade
This study aimed to evaluate the pharmacological effects of haloperidol on the antinociceptive effects of buprenorphine and tramadol in rats. Dose-response curves were constructed for the individual administration of haloperidol, buprenorph...
Synbiotic diet produces antidepressant-like effects but alters ketamine activity in an avian model of treatment-resistant depression [0.03%]
合成益生菌饮食产生抗抑郁作用但会改变凯托米宁的活性：一种难治性抑郁症鸟类模型研究
Stephen W White,Tara D Clover,Kenneth J Sufka
Stephen W White
Pre- and probiotics promote a diverse and functional gut microbiota and have demonstrated both anxiolytic and antidepressant effects; however, how synbiotic diet interacts with antidepressant medications has not been fully investigated. Thi...
Haloperidol potentates the antinociceptive effect of buprenorphine and tramadol in rats [0.03%]
氟哌啶醇增强氯胺酮和右美托咪定的镇痛作用
Rolffy Ortiz-Andrade,Lilian Dolores Chel-Guerrero,Myrna Déciga-Campos
Rolffy Ortiz-Andrade
This study aimed to evaluate the pharmacological effects of haloperidol on the antinociceptive effects of buprenorphine and tramadol in rats. Dose-response curves were constructed for the individual administration of haloperidol, buprenorph...
Prevention of morphine dependence with a combination of ketotifen and l-carnitine in mice: a new potential therapeutic approach [0.03%]
克洛特非宁和左旋肉碱联合预防小鼠吗啡依赖：新的治疗策略
Bohloul Habibi Asl,Solmaz Fallahi,Sanam Bohlouli et al.
Bohloul Habibi Asl et al.
Morphine dependence is a complex clinical issue, coinciding with oxidative stress and increased neurotransmitter levels as key factors in this drug's reliance and tolerance. This study examines how l-carnitine, ketotifen, and their combinat...
Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk [0.03%]
化学信号指示捕食风险下氯硝西泮对特立尼达孔雀鱼的抗焦虑作用
Adam L Crane,Laurence E A Feyten,Alix J P Brusseau et al.
Adam L Crane et al.
The fear of predation is pervasive among vertebrate prey species, being characterized by neurobiological and behavioral changes induced by risk exposure. To understand the acquisition and attenuation of fearful phenotypes, such as dimension...
Interaction effect of lithium and crocin on memory performance and behavioral functions in rats exposed to chronic unpredictable mild stress [0.03%]
锂与红花黄色素对慢性不可预期轻度应激大鼠记忆及行为功能的交互作用效应研究
Delaram Khastoo,Fatemeh Jafari,Batool Ghorbani Yekta et al.
Delaram Khastoo et al.
Chronic unpredictable mild stress (CUMS) is an approved method for the induction of depression in rodents. Lithium, as one of the oldest psychiatric drugs, can induce beneficial effects on mood state under stressful conditions. On the other...