Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization [0.03%]
五羟色胺1b受体杂合和纯合基因敲除对麻黄素致行为敏化的不同作用
Yuki Moriya,Yoshiyuki Kasahara,Kana Ishihara et al.
Yuki Moriya et al.
The psychostimulant drug methamphetamine (METH) causes euphoria in humans and locomotor hyperactivity in rodents by acting on the mesolimbic dopamine (DA) pathway and has severe abuse and addiction liability. Behavioral sensitization, an in...
Methodological approach: using a within-subjects design in the marble burying assay [0.03%]
方法学思路：使用自身对照实验设计进行大理石掩埋试验
Kaitlyn J Partridge,Ruth Olson,Todd M Hillhouse
Kaitlyn J Partridge
In 2016, the National Institutes of Health mandated the use of both male and female mice in funded research. The use of both sexes is an important variable to consider; however, it comes with negative consequences such as increased animal e...
Attenuation of morphine conditioned place preference and reinstatement by vitamin D [0.03%]
维生素D削弱阿片类药物条件位置偏好及复吸现象
Mahdieh Akbari,Houman Parsaei,Katayoun Sedaghat et al.
Mahdieh Akbari et al.
Opioid action in the brain involves the dopamine-reward system as well as non-dopamine pathways. Since vitamin D also modulates the brain's dopamine system, the question of this study was how vitamin D might affect the opioid influences on ...
Dietary-induced binge-like eating impairs acoustic startle responses to acute nisoxetine in male mice [0.03%]
饮食诱导的类似暴食行为会损害雄性小鼠急性尼索替林的听觉惊跳反应
Lori L Scarpa,Nicholas T Bello
Lori L Scarpa
Sensorimotor gating disruptions have been noted in several psychiatric and neurodegenerative disorders. However, the involvement of sensorimotor gating processes in eating disorders has not been well characterized. Our objective was to exam...
Contingency learning in zebrafish exposed to apomorphine- and levetiracetam [0.03%]
施用英夫利昔和左乙拉西坦后的小鼠 contingency 学习能力测试
Christoffel van der Westhuizen,Tarryn L Botha,Karin Finger-Baier et al.
Christoffel van der Westhuizen et al.
Cognitive rigidity (CR) refers to inadequate executive adaptation in the face of changing circumstances. Increased CR is associated with a number of psychiatric disorders, for example, obsessive-compulsive disorder, and improving cognitive ...
Exogenous histamine and H 2 receptor activation and H 3 receptor inhibition in nucleus accumbens modulate formalin-induced orofacial nociception through opioid receptors [0.03%]
外源组胺和核Accumbens中的H2受体激活以及H3受体抑制通过阿片受体调节甲醛诱导的口面部痛觉异常
Azam Notaj,Amir Erfanparast,Esmaeal Tamaddonfard et al.
Azam Notaj et al.
It has been demonstrated that the nucleus accumbens (NAc) plays an important role in modulation of nociception due to its extensive connections with different regions of the brain. In addition, this nucleus receives histaminergic projection...
The integrative role of orexin-1 and orexin-2 receptors within the hippocampal dentate gyrus in the modulation of the stress-induced antinociception in the formalin pain test in the rat [0.03%]
下丘脑阿片黑素浓集肽受体1和2在海马dentategyrus区对大鼠炎症痛模型中应激抗痛作用的整合调控效应研究
Arad Bolouri-Roudsari,Matin Baghani,Kobra Askari et al.
Arad Bolouri-Roudsari et al.
The stressful experiences, by triggering a cascade of hormonal and neural changes, can produce antinociception commonly referred to as stress-induced antinociception (SIA). Orexin neuropeptides have an essential role in stress responses and...
Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats [0.03%]
雌二醇增强米塔扎平对雌性大鼠可卡因诱导的运动敏感性表达的作用
Susana Barbosa-Méndez,Alberto Salazar-Juárez
Susana Barbosa-Méndez
Epidemiological studies have mentioned that cocaine use disorder (CUD) has increased in the last decade among women; these show endocrine and reproductive disorders and a high propensity to stress and depression disorders. Mirtazapine-a tet...
Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia [0.03%]
zymosan A通过刺激海马小胶质细胞在慢性压力的小鼠中产生快速而持续的抗抑郁作用
Tao Zhu,Bingran Chen,Han Han et al.
Tao Zhu et al.
Recent studies had reported that compounds that stimulate microglia could be developed as potential drugs for the treatment of depression due to their reversal effect on depression-like behaviors in chronically stressed mice. Zymosan A is a...
The effectiveness of oxytocin in the treatment of stimulant use disorders: a systematic review [0.03%]
催产素在刺激性物质使用障碍治疗中有效性的系统综述研究
Stephen Lee-Cheong,Sacha A Ludgate,Tanisse C M Epp et al.
Stephen Lee-Cheong et al.
Objectives: The purpose of this review is to examine human study evidence on the effectiveness of oxytocin in this patient population. Despite stimulant use disorder being a major public health concern, there are no valid...