Restricted psychological horizon in active methamphetamine users: future, past, probability, and social discounting [0.03%]
冰毒使用者的心理局限性：未来、过去、概率和社会折现理论中的表现缺陷
Richard Yi,Anne E Carter,Reid D Landes
Richard Yi
Methamphetamine users (MAU) exhibit an exaggerated bias for immediate rewards that reflects a restricted time horizon, where outcomes in the future are excessively discounted. An accumulating literature indicates that time in the future sha...
Parametric studies of antipsychotic-induced sensitization in the conditioned avoidance response model: roles of number of drug exposure, drug dose, and test-retest interval [0.03%]
条件性逃避反应模型中抗精神病药物敏感化现象的参数研究：给药次数、剂量及测验间隔的角色分析
Natashia Swalve,Ming Li
Natashia Swalve
Repeated haloperidol and olanzapine treatment produces an enhanced disruption of avoidance responding, a validated measure of antipsychotic activity. Experimental parameters affecting this sensitization-like effect have not been thoroughly ...
Comparative Study
Behavioural pharmacology. 2012 Aug;23(4):380-91. DOI:10.1097/FBP.0b013e32835651ea 2012
Ontogeny of methamphetamine-induced and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats [0.03%]
断乳前期和青春期大鼠一次性伏隔核给予甲基苯丙胺或可卡因后行为敏感化的发生发展研究
Olga O Kozanian,Arnold Gutierrez,Alena Mohd-Yusof et al.
Olga O Kozanian et al.
The ontogenetic profile of psychostimulant-induced one-trial behavioral sensitization has not been determined. The purpose of this study was to systematically assess the ontogeny of methamphetamine-induced and cocaine-induced behavioral sen...
Comparative Study
Behavioural pharmacology. 2012 Aug;23(4):367-79. DOI:10.1097/FBP.0b013e32835651c9 2012
Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice [0.03%]
N-去甲基氯氮平，不典型抗精神病药物氯氮平的主要活性代谢产物，在C57BL/6小鼠中的辨別刺激属性
Jason M Wiebelhaus,Sarah A Vunck,Herbert Y Meltzer et al.
Jason M Wiebelhaus et al.
N-desmethylclozapine (NDMC) is the major active metabolite of the atypical antipsychotic drug clozapine and may contribute to the therapeutic efficacy of clozapine. Although they share many pharmacological features, it is noteworthy that ND...
Preference reversals and effects of D-amphetamine on delay discounting in rats [0.03%]
D-安非他明对大鼠延迟折扣偏好的反转效应
Christopher A Krebs,Karen G Anderson
Christopher A Krebs
Impulsive choice is correlated with behavioral problems such as attention-deficit/hyperactivity disorder and substance abuse. Effects of stimulant drug administration on impulsive choice are not consistent and may depend on baseline differe...
Coadministration of cannabinoid CB1-receptor and adenosine A1-receptor antagonists improves the acquisition of spatial memory in mice: participation of glutamatergic neurotransmission [0.03%]
大麻素CB1受体和腺苷A1受体拮抗剂联合给药通过谷氨酸能神经传递改善小鼠空间记忆的获得
Fabrício Luiz Assini,Carina Akemi Nakamura,Tetsade Camboim Piermartiri et al.
Fabrício Luiz Assini et al.
The aim of this study was to characterize the interaction of adenosine A1-receptor and cannabinoid CB1-receptor antagonists in the water maze and object-location tasks, and to evaluate the participation of glutamatergic neurotransmission in...
The phosphodiesterase inhibitor isobutylmethylxanthine attenuates behavioral sensitization to cocaine [0.03%]
磷酸二酯酶抑制剂异丁基甲基黄嘌呤可减轻可卡因的行为敏感化作用
Joseph A Schroeder,Jeffrey D Ruta,Jessica S Gordon et al.
Joseph A Schroeder et al.
The factors influencing sensitization to cocaine are complex and likely include both cellular and neural systems factors. Upregulation of the striatal dopamine cAMP-signaling pathway and enhanced accumbens adenosine tone are two mechanisms ...
Potential involvement of tyrosine phosphatase and calpain-related pathways in opioid withdrawal syndrome in mice [0.03%]
小鼠阿片类药物戒断综合征中酪氨酸磷酸酶和钙蛋白酶相关通路的潜在作用
Ashish K Rehni,Nirmal Singh
Ashish K Rehni
The present study was designed to determine the effect of N'-[6,7-dichloro-4-(4-methoxy-phenyl)-3-oxo-3,4-dihydroquinoxalin-2-yl] hydrazide (SJA 7019), a selective nonpeptide inhibitor of calpain, and sodium orthovanadate, a selective inhib...
Effects of repeated oxycodone administration on its analgesic and subjective effects in normal, healthy volunteers [0.03%]
反复使用羟考酮对正常健康志愿者镇痛作用和主观感受的影响
Ziva D Cooper,Maria A Sullivan,Suzanne K Vosburg et al.
Ziva D Cooper et al.
Tolerance to the analgesic effects of opioids has been demonstrated in laboratory animals after repeated drug administration; yet, this effect has been studied less frequently under controlled laboratory conditions in humans. This within-su...
Controlled Clinical Trial
Behavioural pharmacology. 2012 Jun;23(3):271-9. DOI:10.1097/FBP.0b013e3283536d6f 2012
A comparison of dehydroepiandrosterone and 7-keto dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule [0.03%]
一项关于DHEA和7-酮-DHEA与其他调控大鼠乙醇摄入药物的比较研究（在执行多重任务的日程下）
Russell Joseph Amato,Mary Worrel Hulin,Peter John Winsauer
Russell Joseph Amato
Dehydroepiandrosterone (DHEA), 7-keto DHEA, and several comparison drugs (ethanol, chlordiazepoxide, rauwolscine, and RO15-4513) were administered to male rats responding under a multiple schedule of food and ethanol presentation to determi...
Comparative Study
Behavioural pharmacology. 2012 Jun;23(3):250-61. DOI:10.1097/FBP.0b013e32835342d2 2012