Chronic caffeine decreases anxiety-like behavior in the marble burying task in adolescent rats [0.03%]
慢性咖啡因减少青春期大鼠迷宫埋藏行为的焦虑样表现
Gwi Park,Sarah M Turgeon
Gwi Park
Exposure to chronic caffeine during adolescence has been shown to produce decreased anxiety-like behaviors in rats as well as decreased immobility in the forced swim test (FST) suggesting an antidepressant-like effect. The effects of chroni...
Is impulsivity related to attentional bias in cigarette smokers? An exploration across levels of nicotine dependency and deprivation [0.03%]
冲动性与吸烟者的注意力偏向有关吗？不同尼古丁依赖程度和缺乏状态下的探讨
Katerina Z Kolokotroni,Therese E Fozard,Danielle L Selby et al.
Katerina Z Kolokotroni et al.
Research has largely focused on how attentional bias to smoking-related cues and impulsivity independently influence the development and maintenance of cigarette smoking, with limited exploration of the relationship between these mechanisms...
Crocin (bioactive compound of Crocus sativus L.) potently restores REM sleep deprivation-induced manic- and obsessive-compulsive-like behaviors in female rats [0.03%]
藏红花生物活性化合物克罗辛对雄性大鼠快速眼动睡眠剥夺诱导的躁狂样和强迫症样行为的治疗作用
Mohammad Houshyar,Hanie Karimi,Zahra Ghofrani-Jahromi et al.
Mohammad Houshyar et al.
Rapid-eye movement (REM) sleep deprivation (SD) can induce manic-like behaviors including hyperlocomotion. On the other hand, crocin (one of the main compounds of Crocus sativus L. or Saffron) may be beneficial in the improvement of mental ...
SKF82958, a dopamine D1 receptor agonist, disrupts prepulse inhibition in the medial prefrontal cortex and nucleus accumbens in C57BL/6J mice [0.03%]
SKF82958（多巴胺D1受体激动剂）通过中前额叶皮层和伏隔核破坏C57BL/6J小鼠的prepulse抑制效应
Chengmei Yang,Xiaoyu Chen,Jingyang Xu et al.
Chengmei Yang et al.
Prepulse inhibition (PPI) is a crucial indicator of sensorimotor gating that is often impaired in neuropsychiatric diseases. Although dopamine D1 receptor agonists have been found to disrupt PPI in mice, the underlying mechanisms are not fu...
Activation of mGlu 2/3 receptors with the orthosteric agonist LY-404,039 alleviates dyskinesia in experimental parkinsonism [0.03%]
新型mGlu2/3激动剂LY404039治疗帕金森病激越症状小鼠模型中的疗效研究
Woojin Kang,Imane Frouni,Cynthia Kwan et al.
Woojin Kang et al.
LY-404,039 is an orthosteric agonist at metabotropic glutamate 2 and 3 (mGlu 2/3 ) receptors, with a possible additional agonist effect at dopamine D 2 receptors. LY-404,039 and its pro-drug, LY-2140023, have previously been tested in clini...
Neuronal nicotinic acetylcholine receptor of the central amygdala modulates the ethanol-induced tolerance to anxiolysis and withdrawal-induced anxiety in male rats [0.03%]
中央杏仁核的神经元烟碱型乙酰胆碱受体调节雄性大鼠对酒精诱导的抗焦虑耐受性和戒断引起的焦虑情绪
Antariksha Duratkar,Richa Patel,Nishant Sudhir Jain
Antariksha Duratkar
The nicotine acetylcholinergic receptor (nAchR) in the central nucleus of the amygdala (CeA) is known to modulate anxiety traits as well as ethanol-induced behavioral effects. Therefore, the present study investigated the role of CeA nAChR ...
Antinociceptive and adverse effects of morphine:ketamine mixtures in rats [0.03%]
吗啡：氯胺酮混合物在大鼠中的镇痛和不良反应研究
Conor D Strumberger,Evangeline J D&#x;Epagnier,Kevin H Nguyen et al.
Conor D Strumberger et al.
Prescription opioids are the gold standard for treating moderate to severe pain despite their well-documented adverse effects. Of all prescription medications, opioids are abused most widely, and fatal overdoses have reached epidemic levels...
Opioid receptor antagonists reduce motivated wheel-running behavior in mice [0.03%]
阿片受体拮抗剂可降低小鼠的觅乐跑步行为
Nobue Kitanaka,Kanayo Arai,Kaoko Takehara et al.
Nobue Kitanaka et al.
We hypothesized that opioid receptor antagonists would inhibit motivated behavior produced by a natural reward. To evaluate motivated responses to a natural reward, mice were given access to running wheels for 71.5 h in a multi-configuratio...
Positive modulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors differentially alters spatial learning and memory in juvenile rats younger and older than three weeks [0.03%]
α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体的正向调节对三周龄以上和以下幼鼠的空间学习和记忆产生差异化影响
Nicholas R Mill,Richard H Ogoe,Nazanin Valibeigi et al.
Nicholas R Mill et al.
Remarkable performance improvements occur at the end of the third postnatal week in rodents tested in various tasks that require navigation according to spatial context. While alterations in hippocampal function at least partially subserve ...
Examination of the mechanisms underlying the discriminative stimulus properties of the atypical antipsychotic amisulpride [0.03%]
非典型抗精神病药物阿米舒必利区分刺激特性机制的研究
Timothy J Donahue,Todd M Hillhouse,Kevin A Webster et al.
Timothy J Donahue et al.
Amisulpride is an atypical benzamide antipsychotic/antidepressant, whose mechanism of action is thought to depend mainly on dopamine D2/3 receptor activity, but also with some serotonin 5-HT2B/7 effects. The present study examined the role ...