Drug-specific effects of anxiety on high-dose oxycodone: age as a modifier for oxycodone response [0.03%]
焦虑对高剂量羟考酮的药物特异性效应：年龄作为羟考酮反应的调节因素
Longyue Wang,Wei Chai,Bingrong Wang et al.
Longyue Wang et al.
To investigate the association between preoperative anxiety and opioid tolerance in patients undergoing primary hip arthroplasty, focusing on heterogeneity across opioid types and the mechanisms underlying this association, this retrospecti...
Polygalic acid produces rapid antidepressant effects via modulation of hippocampal inflammation and brain-derived neurotrophic factor expression in mice [0.03%]
聚乙二醇酸通过调节小鼠海马炎症和脑源性神经营养因子表达产生快速抗抑郁作用
Jinjin Xie,Jie Dong,Haixiu Liao et al.
Jinjin Xie et al.
Major depressive disorder represents a critical global health burden with limited rapid-acting therapeutic options. This study investigated the natural triterpenoid saponin polygalic acid for rapid antidepressant efficacy and its mechanisti...
Behavioral and pharmacological validation of the differential reinforcement of low-rate behavior paradigm in non-human primates [0.03%]
用于非人灵长类动物低频行为差异增强范式的实验行为和药理学验证研究
Casey R Vanderlip,Shelby R Dunn,Jennifer L Basile et al.
Casey R Vanderlip et al.
Depression remains a leading cause of disability worldwide, yet the predictive validity of many preclinical behavioral assays for antidepressant efficacy remains limited. The differential reinforcement of low-rate behavior (DRL) task has cl...
Sex-dependent analgesic effects of phoenixin-14 on mechanical allodynia in mouse models of neuropathic and inflammatory pain [0.03%]
凤九肽-14缓解小鼠神经病理性疼痛和炎症性痛觉异常的性别差异依赖效应研究
Jing Li,WeiWei Li,Zhe Wang et al.
Jing Li et al.
Chronic pain is a common complication of many diseases, often leading to severe hyperalgesia and allodynia with limited therapeutic options. Opioids are restricted in widespread clinical use due to side effects such as addiction and toleran...
Shigeru Watanabe
Shigeru Watanabe
Some drugs possess reinforcing properties, which are commonly studied using the conditioned place preference (CPP) paradigm. CPP has been applied across a wide range of taxa, including nonmammalian vertebrates and invertebrates. In the pres...
Behavioural phenotyping with small aquatic model organisms: why digital video resolution and bitrate matter [0.03%]
基于小型水生模式生物的行为表型分析：视频数字化分辨率和比特率的影响
Hy Do,Florian Kreuder,Xuhui Han et al.
Hy Do et al.
Behavioural analysis with small aquatic model organisms is increasingly applied across diverse areas of biosciences and biomedicine, including ecology, pharmacology, and experimental neurobiology. High-throughput behavioural phenotyping wor...
Intermediate doses of d-amphetamine promote perseverative risky choices following the presentation of win-paired cues [0.03%]
intermediate剂量的d-安非他命会在呈现获胜配对线索后促进持续性冒险选择
Connor M Lambert,Karen G Anderson
Connor M Lambert
Choosing a relatively large reward with a lower chance of payoff compared with a relatively small reward with a higher chance of payoff can be operationalized as a risky choice. Risky choices are often observed in humans through gambling. G...
N-acetylcysteine: a promising strategy for alleviating damages induced by maternal deprivation in neonatal rats [0.03%]
N-乙酰半胱氨酸：一种有前景的策略，可减轻母体剥夺对新生大鼠损伤的影响
Hoda Shariatmadari,Mohammad Reza Bigdeli,Sepideh Khaksar et al.
Hoda Shariatmadari et al.
Maternal deprivation in the postnatal period triggers complex conditions along with impairment in brain development. Research indicates that N-acetyl-L-cysteine (NAC), a nootropic agent, restores glutathione levels for antioxidant protectio...
Increasing the number of extinction sessions suppresses context-specific sensitization in mice [0.03%]
增加消亡次数可抑制小鼠特定上下文敏感化反应
Anthony S Rauhut
Anthony S Rauhut
The present experiment examined the effects of the number of conditioned stimulus sessions on (a) the rate of extinction of conditioned hyperactivity and (b) the subsequent expression of context-specific sensitization in mice. Male, Swiss W...
Effects of gabapentin on heroin and cocaine self-administration in rats [0.03%]
加巴喷丁对大鼠海洛因和可卡因自给行为的影响
Shawn M Flynn,Han Namgoong,Charles P France
Shawn M Flynn
Reports of gabapentin misuse among people with opioid use disorder have increased, as has the presence of gabapentin in opioid overdose deaths. Despite these trends and known interactions between these drugs in other settings (e.g. gabapent...