First-line treatment with a combination of immunotherapy, anti-EGFR monoclonal antibodies, and chemotherapeutics for unresectable left KRAS/BRAF wild-type microsatellite-stable colorectal cancer: a case report [0.03%]
左半非RAS和BRAF突变型微卫星稳定不可切除结直肠癌一线免疫治疗联合抗EGFR单克隆抗体及化疗一例报告
Yaoyi Zhang,Dongfeng Wang,Ke Zhang et al.
Yaoyi Zhang et al.
Immunotherapy shows limited efficacy in microsatellite-stable (MSS) colorectal cancer. This case report describes a 40-year-old male with left-sided kirsten rat sarcoma viral oncogene homolog (KRAS)/v-raf murine sarcoma viral oncogene homol...
Benefit of switching to firmonertinib following almonertinib-induced interstitial pneumonitis in a patient with advanced non-small-cell lung cancer: a case report [0.03%]
艾洛替尼引起的间质性肺炎患者转化使用菲莫纳蒂尼的疗效：一例晚期非小细胞肺癌患者的报告
Lingying Wang,Pan Yang,Hu Luo
Lingying Wang
Almonertinib, a representative epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is the first-line standard treatment for EGFR-mutant advanced non-small-cell lung cancer; however, it may induce drug-related interstitial...
Denticleless homolog-mediated ubiquitin-proteasome degradation of forkhead box O1 contributes to development of carboplatin resistance in retinoblastoma [0.03%]
泛素-蛋白酶体降解FOXO1介导的DNTL同源物促进视网膜母细胞瘤顺铂耐药性的发生发展
Xian Liu,Shou-Feng Jiao,Chun-Yi Liu et al.
Xian Liu et al.
This study aimed to investigate the role of forkhead box O1 (FOXO1) in carboplatin-resistant retinoblastoma (RB) cells, focusing on its subcellular distribution and regulation through ubiquitin-dependent degradation mediated by denticleless...
APG-115 synergizes with bortezomib to induce apoptosis in cervical cancer cells [0.03%]
APG-115与硼替佐米联合诱导宫颈癌细胞凋亡
Chuanyue Sun,Xueqiong Meng,Xiaoxi Cui et al.
Chuanyue Sun et al.
Despite significant advancements in vaccination, screening, and therapeutic strategies have substantially reduced cervical cancer incidence, effective treatment for this disease remains a major clinical challenge. This study reveals that AP...
Early sensitivity and rapid resistance to drug therapy in primary pulmonary nuclear protein in testis carcinoma [0.03%]
睾丸肺原发性生殖细胞瘤对药物治疗早期敏感性和快速耐药性的体外试验评估
Ji Ma,Yaru Tian,Yan Zhang et al.
Ji Ma et al.
Nuclear protein in testis (NUT) carcinoma is a rare disease characterized by aggressive and rapid progression. There is no standard management of primary pulmonary NUT carcinoma until now, and the median overall survival is only 4.4 months....
A case of diabetic ketoacidosis triggered by immune checkpoint inhibitors in the treatment of recurrent nasopharyngeal carcinoma [0.03%]
免疫检查点抑制剂治疗复发性鼻咽癌诱发的糖尿病酮症酸中毒1例
Shuting Xian,Liu Yang,Chunmiao Wang et al.
Shuting Xian et al.
Immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) have been widely documented. Diabetic ketoacidosis (DKA), a severe irAEs, has not been previously reported in patients with nasopharyngeal carcinoma (NPC). ...
Rapid radiological response of leptomeningeal carcinosis and prolonged survival to encorafenib and binimetinib in BRAF-mutated melanoma [0.03%]
恩考芬尼和比美替尼治疗BRAF突变型黑色素瘤引起的硬膜弥漫性癌快速放射学反应及较长生存期的病例报告
Giacomo Corradi,Sara De Martino,Angela Rinaldi et al.
Giacomo Corradi et al.
Among solid tumors, malignant melanoma (MM) has the highest risk of metastasis to the leptomeninges, for which a specific therapeutic regimen has not been established yet. This case report describes a rapid partial response to leptomeningea...
Synthesis, characterization and evaluation of linoleic acid-loaded nano-carriers: a novel drug delivery system for efficient treatment of hepatocellular carcinoma [0.03%]
载亚油酸纳米载体的合成、表征及评价：一种高效治疗肝细胞癌的新药物递送系统
Mahsa Ghasemzad,Haleh Bakhshandeh,Roghayeh Naserkhaki et al.
Mahsa Ghasemzad et al.
Hepatocellular carcinoma is the main primary liver cancer. Due to the high recurrence rate and potential resistance to treatments, there is an urgent need to find more effective and targeted therapies. Combinational therapies and using adva...
Anlotinib for the treatment of pulmonary epithelioid inflammatory myofibroblastic sarcoma: a case report [0.03%]
安罗替尼治疗肺类上皮样炎性肌纤维母细胞瘤1例报告
Huanling Zeng,Xin Li,Shengli Chen et al.
Huanling Zeng et al.
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare subtype of inflammatory myofibrosarcoma. Anlotinib has demonstrated efficacy in the treatment of sarcoma. Nevertheless, to our knowledge, its use in EIMS has not been reporte...
Nivolumab- and ipilimumab-induced myositis, myasthenia gravis, and myocarditis in a patient with metastatic melanoma [0.03%]
一例黑色素瘤患者使用尼伏单抗和伊匹单抗引发的肌炎、重症肌无力及心肌炎病例报告
Berin Inan,Ulkuhan Duzgun,Zeynep Ergul-Ulger et al.
Berin Inan et al.
Immune checkpoint inhibitors (ICIs) have revolutionized advanced cancer treatment and prolonged survival; however, they are associated with several immune-related adverse events in up to 60% of patients, affecting various organ systems. A 7...