D430-2307 inhibits breast cancer cell growth by dual induction of apoptosis and G0/G1 arrest via phosphatidylinositol 3-kinase/protein kinase B signaling [0.03%]
Jingge Xu,Shuling Ni,Yi Yang et al.
Jingge Xu et al.
D430-2307 is a novel small-molecule compound identified through virtual screening of the Chemdiv database that markedly inhibited the proliferation of both MCF-7 and MDA-MB-231 breast cancer cells. In the present study, the anticancer activ...
APG-1252 enhances the anticancer role of paclitaxel in non-small-cell lung cancer cells by suppressing the extracellular regulated protein kinases/myeloid cell leukemia 1 pathway [0.03%]
APG-1252通过抑制外源性调节蛋白激酶/髓系细胞白血病1途径增强对非小细胞肺癌细胞的抗癌作用
Luxi Qian,Zizhang Guo,Xiang Cao et al.
Luxi Qian et al.
The efficacy of paclitaxel (PTX), an important chemotherapy drug in non-small-cell lung cancer (NSCLC) cells, is limited by its resistance. APG-1252 has an inhibitory role in cancer and can inhibit myeloid cell leukemia 1 (MCL-1) to enhance...
The good, the bad, and the manageable: real-world outcomes with CDK4/6 inhibitors [0.03%]
CDK4/6抑制剂的现实世界结局：好的、坏的和可管理的
Alexandra Paulet,Silvia Mancini,Martina Catalano et al.
Alexandra Paulet et al.
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in combination with endocrine therapy represent the standard of care for hormone receptor-positive (HR+), HER2-negative metastatic breast cancer (mBC). While clinical trials established their...
Dual checkpoint inhibition achieves successful treatment of diffuse bilateral lung metastasis in giant advanced liver cancer: a case report [0.03%]
两种检查点抑制剂联合治疗巨大晚期肝癌伴双肺弥漫转移的成功病例报告
Ting-Ting Xie,Wang Chen,Zi-Han Zeng et al.
Ting-Ting Xie et al.
Advanced hepatocellular carcinoma (HCC) with extensive metastases is associated with a poor prognosis, highlighting the need for individualized, multimodal treatment strategies. We present the case of a 54-year-old male with advanced HCC (c...
Human Epidermal Growth Factor Receptor-2 positive metastatic salivary duct carcinoma with remarkable response to targeted therapy: a case report and therapeutic implications [0.03%]
人类表皮生长因子受体-2阳性腮腺导管癌伴转移病灶对靶向治疗反应良好：一例报告及治疗启示
Clara Rodrigo Juan,Carla Climent Vicente,Francisco Xavier Avilés Jurado et al.
Clara Rodrigo Juan et al.
Salivary duct carcinoma (SDC) is a rare and highly aggressive malignancy that frequently overexpresses Human Epidermal Growth Factor Receptor 2 (HER2). Despite the increasing recognition of HER2-targeted strategies, evidence remains limited...
Acquired FGFR2 mutation leads resistance to pemigatinib in a patient with FGFR2-driven Borrmann type IV gastric cancer [0.03%]
获得FGFR2突变导致FGFR2驱动的鲍曼四型胃癌患者佩米昔替尼耐药
Qiong Sun,Sicheng Du,Jing Meng et al.
Qiong Sun et al.
Scirrhous gastric cancer (SGC), including the Borrmann type IV subtype, is characterized by a desmoplastic stroma, rapid progression, and a poor prognosis with limited effective treatment options. While fibroblast growth factor receptor 2 (...
Dauricine induces ferroptosis in neuroblastoma by inhibiting methyltransferase-like 1-mediated N7-methylguanosine methylation of solute carrier family 3 member 2 [0.03%]
胆色素脱氧核苷酸通过抑制N7-甲基鸟苷酸甲基化酶样蛋白1介导的SLC3A2甲基化在神经母细胞瘤中诱导铁死亡
Liping Tang,Na Huang,Tianyun Li et al.
Liping Tang et al.
Neuroblastoma is one of the most common extracranial solid tumors in children, characterized by high heterogeneity, aggressive biological behavior, and poor clinical prognosis. Ferroptosis, a form of programmed cell death driven by iron acc...
The PITX2/CKMT1B axis promotes lung adenocarcinoma stemness via lipid accumulation [0.03%]
PITX2/CKMT1B轴通过脂质积累促进肺腺癌干细胞特性
Longshan Zhou,Xiaoping Jin,Yuchao Shen et al.
Longshan Zhou et al.
Dysregulated expression of mitochondrial creatine kinase 1B (CKMT1B), a member of the creatine kinase family, has been linked to tumor progression. However, its specific function in lung adenocarcinoma (LUAD) remains unclear. Bioinformatics...
Isovanillin regulates gastric cancer cells apoptosis and metastasis by targeting ROS-mediated MAPK and PI3K signaling pathways [0.03%]
异香豆素通过靶向ROS介导的MAPK和PI3K信号通路调节胃癌细胞凋亡及转移
Jing-Jing Wen,Xiao-Yu Jin,Ying-Hua Luo et al.
Jing-Jing Wen et al.
Isovanillin, a natural coumarin compound, exhibits biological functions; however, its anti-gastric cancer process is not well understood. This research examined the pathway underlying isovanillin's effects on gastric cancer cells. Cell viab...
Evaluation of the protective effect of chamomile oral solution on the incidence of neurotoxicity caused by paclitaxel in breast cancer patients [0.03%]
评估洋甘菊口服溶液对乳腺癌患者因紫杉醇所致神经毒性的保护作用评价
Nasim Nikkhah,Hedyieh Karbasforooshan,Soodabeh Shahid Sales et al.
Nasim Nikkhah et al.
Neurotoxicity is one of the major complications in cancer patients following paclitaxel-containing regimens. Matricaria chamomilla L., isolated from the German chamomile, has anti-inflammatory and antioxidant features. In this study we eval...