Eugenol as a game-changer: overcoming osimertinib resistance in non-small cell lung cancer by inhibiting glycolysis via the tripartite motif containing 59/extracellular signal-regulated kinase pathway [0.03%]
丁香酚通过三聚体亮氨酸重复结构域59/细胞外信号调节激酶途径抑制糖酵解克服非小细胞肺癌中奥希替尼耐药性研究
Kun Zhao,Wei Wang,Yansha Sun et al.
Kun Zhao et al.
Eugenol plays a significant role in various cancers and can influence the sensitivity of cancer cells to chemotherapy. This study aimed to investigate the mechanism by which eugenol regulates glycolysis through the tripartite motif containi...
Treatment of HRD-positive elderly ovarian cancer patient: a case report [0.03%]
HRD阳性老年卵巢癌患者的治疗：1例报告
Yuxin Jiang,Qijun Yi,Yueer Wang et al.
Yuxin Jiang et al.
The standard treatment for advanced ovarian cancer follows a comprehensive 'surgery-chemotherapy-maintenance therapy' mode, typically involving initial cytoreductive surgery aiming for R0 resection, six cycles of platinum-based chemotherapy...
EP4 influences bortezomib resistance in multiple myeloma by modulating endoplasmic reticulum stress via the phosphatidylinositol 3-kinase/protein kinase B pathway [0.03%]
EP4通过磷脂酰肌醇3-激酶/蛋白激酶B途径调节内质网应激影响骨髓瘤硼替佐米抗性
Tengfei Shi,Yao Chen,Zhiqiang Liu et al.
Tengfei Shi et al.
Multiple myeloma, a hematologic malignancy characterized by the uncontrolled proliferation of plasma cells, presents a significant therapeutic challenge, particularly due to the development of resistance to bortezomib, a cornerstone in its ...
A new anilinoquinazoline derivative, F307 induces autophagy and differential apoptosis in wild-type and mutated-epidermal growth factor receptor non-small cell lung cancer cell lines [0.03%]
一种新的茋类衍生物F307能够诱导野生型和突变型表皮生长因子受体非小细胞肺癌细胞系的自噬及差异性凋亡
Rashidi Dzul Keflee,Kok Hoong Leong,Muhammad Kumayl Abdulwahab et al.
Rashidi Dzul Keflee et al.
Non-small-cell lung cancer (NSCLC) often develops epidermal growth factor receptor (EGFR) mutations that respond poorly to chemotherapy with complicated resistance mechanisms, limiting the long-term treatment success. This study is to deter...
Precision design of an HLA-I-targeted multiepitope vaccine against human papillomavirus 16 oncoproteins E6/E7: integrated immunoinformatic and immunogenicity profiling [0.03%]
一种针对人类乳头瘤病毒16型致癌蛋白E6/E7的HLA-I靶向多表位疫苗的精确诊疗及对免疫信息和免疫学特征的综合评价
Jie Dai,Rui Yang,Yina Cun et al.
Jie Dai et al.
Viral oncogenes E6 and E7 are ideal targets for therapeutic vaccines against human papillomavirus (HPV)-associated cervical cancer (CC). T cell-mediated immunity plays a crucial role in the clearance of HPV infection and regression of intra...
Ubiquitylation-oxaliplatin-related prognosis signature reveals the landscapes of immune responses, cell communication, and therapeutic sensitivity for colorectal cancer [0.03%]
泛素化-奥沙利铂相关预后标志物揭示结直肠癌免疫反应、细胞通讯和治疗敏感性的景观特征
Gongjun Zhang,Xinye Chen
Gongjun Zhang
Ubiquitylation plays a crucial role in posttranslational modification, and its dysregulation is linked to chemosensitivity. However, its role in oxaliplatin (OXA) resistance in colorectal cancer (CRC) remains unclear. Transcriptomic data fr...
Activation of the caspase-1/gasdermin D pathway via α-linolenic acid-mediated GPR120 signaling induces pyroptosis and suppresses ovarian cancer tumor growth [0.03%]
α-亚麻酸通过GPR120信号激活caspase-1/GSDMD通路诱导卵巢癌细胞pyroptosis及抑制肿瘤生长
Shijie Sun,Li Qian
Shijie Sun
To investigate the role and underlying mechanism of α-linolenic acid (ALA) in ovarian cancer (OC), particularly its relationship with pyroptosis and the GPR120/caspase-1/Gasdermin D (GSDMD) pathway. Human OC cell lines (SKOV3, A2780), THP-...
A novel anticancer natural product SP09 selectively targets KRAS-mutant NSCLC through LKB1/AMPK/mTOR modulation: implications for novel therapeutic development [0.03%]
一种新型天然抗癌产物SP09通过LKB1/AMPK/mTOR调节靶向KRAS突变的非小细胞肺癌：对开发新疗法的意义
Peng Yue,Chitin Hon,Xiaoping Zhao et al.
Peng Yue et al.
KRAS-mutant non-small cell lung cancer (NSCLC) remains a major therapeutic challenge due to the paucity of effective targeted agents. Although covalent KRAS^G12C inhibitorsi such as sotorasib and adagrasib have demonstrated clinical activit...
Comparative efficacy and safety of S-1 plus oxaliplatin with sintilimab vs. paclitaxel-S-1-oxaliplatin and docetaxel-oxaliplatin-5-fluorouracil as first-line therapy for advanced gastric cancer [0.03%]
替雷利珠单抗联合S-1和奥沙利铂对比其他化疗方案作为晚期胃癌一线治疗的疗效和安全性比较研究
Yicong Wang,Bingyang Ma,Chenguang Zhang et al.
Yicong Wang et al.
This study compared the efficacy and safety of S-1 + oxaliplatin (SOX) plus sintilimab, albumin-bound paclitaxel + oxaliplatin (P-SOX), and docetaxel + oxaliplatin + 5-fluorouracil (DOF) as neoadjuvant regimens for advanced gastric cancer. ...
Unlocking the role of prostate transmembrane androgen inducible protein 1 in gemcitabine resistance: modulation of P38-mitogen-activated protein kinase/C-C motif chemokine ligand 2 and M2 macrophage polarization in bladder cancer [0.03%]
前列腺膜结合雄激素诱导蛋白1在吉西他滨耐药中作用的解析：P38-丝裂原活化蛋白激酶/C-C基序趋化因子配体2及M2型巨噬细胞极化在膀胱癌中的调节作用
Gang Yang,Xiaoyu Zhu,Wu Wei et al.
Gang Yang et al.
Bladder cancer (BLCA) is a highly aggressive malignancy, with chemotherapy resistance being a significant factor in treatment failure. In the tumor microenvironment, M2 macrophage polarization is essential for immune suppression and treatme...