Real-life data on adjuvant trastuzumab emtansine treatment in early-stage HER2-positive breast cancer: a Turkish Oncology Group study [0.03%]
早期HER2阳性乳腺癌辅助emtansine曲妥珠单抗治疗的现实世界数据：土耳其肿瘤组研究
Selin Akturk Esen,Ismet Seven,Gonca Akdere Ates et al.
Selin Akturk Esen et al.
In this Turkish Oncology Group study, we aimed to evaluate the effectiveness of trastuzumab emtansine (TDM1) in the adjuvant treatment of early-stage human epidermal growth factor receptor-2 (HER2)-positive breast cancer with residual disea...
Correlative analysis of immune-related thyroid dysfunction and prognosis in patients with advanced esophageal squamous cell carcinoma [0.03%]
晚期食管鳞状细胞癌患者免疫相关甲状腺功能障碍与预后相关性分析
Liangshan Da,Ziting Qu,Yiyin Zhang et al.
Liangshan Da et al.
To explore the clinical characteristics of immune-related thyroid dysfunction (TD) and its correlation with prognosis. By collecting the clinical data of 116 patients with advanced esophageal squamous cell carcinoma (ESCC) who received prog...
Treatment of RET/ALK comutated advanced lung large cell neuroendocrine carcinoma: a case report and literature review [0.03%]
RET/ALK共突变治疗晚期肺大细胞神经内分泌癌一例报告及文献回顾
Ying Luo,De Li,Qi Yang et al.
Ying Luo et al.
The prognosis of advanced lung large-cell neuroendocrine carcinoma is poor, and the efficacy of targeted therapy is still being explored. A case of RET fusion mutation combined with ALK rearrangement positive advanced lung complex large cel...
Metformin-induced E6/E7 inhibition prevents HPV-positive cancer progression through p53 reactivation [0.03%]
二甲双胍诱导的E6 / E7抑制通过p53活化防止HPV阳性癌症进展
Ruiyang Zhang,Feifei Hou,Jianguo Gan et al.
Ruiyang Zhang et al.
The human papillomavirus (HPV) is implicated in multiple lethal cancers, although it is more sensitive to certain therapies than HPV-negative cancers. Therefore, the development of more targeted therapeutic strategies is imperative. The HPV...
FV-429 suppresses cancer cell migration and invasion by EMT via the Hippo/YAP1 pathway in pancreatic cancer cells [0.03%]
FV-429通过Hippo / YAP1通路抑制胰腺癌细胞中的EMT从而抑制癌症细胞的迁移和侵袭
Zhiying Wang,Xingxing Pan,Xinyue Ma et al.
Zhiying Wang et al.
Pancreatic cancer is one of the most common malignant tumors of the digestive system, with the majority of patients not succumbing to the primary tumor but rather to metastasis. Epithelial-mesenchymal transition (EMT) is abnormally activate...
GZ17-6.02 interacts with carboplatin and etoposide to kill neuroblastoma cells [0.03%]
GZ17-6.02与卡铂和依托泊苷相互作用以杀死神经母细胞瘤细胞
Michael R Booth,Laurence Booth,Jane L Roberts et al.
Michael R Booth et al.
The biology of GZ17-6.02 alone and more so in combination with either of the standard-of-care agents etoposide or carboplatin killed MYCN overexpressing neuroblastoma (NB) cells is unknown. The methods involved in this study are in-cell imm...
Efficacy of disitamab vedotin (RC48) for previously treated human epidermal growth factor receptor 2-positive breast cancer with symptomatic brain metastases: a case report and review of the literature [0.03%]
迪西塔木单抗维多汀（RC48）对既往治疗过的HER2阳性伴症状性脑转移乳腺癌的疗效：一例病例报告及文献回顾
Can Yang,Cui Zhang,Yisidan Huang et al.
Can Yang et al.
Local radiotherapy or surgery is the standard of care for treating brain metastases among patients with breast cancer. However, affected by tumor subtype, more than 50% of human epidermal growth factor receptor 2 (HER2)-positive metastatic ...
Identification and validation of mitochondria-related LncRNA signatures as a novel prognostic model for glioma [0.03%]
与线粒体相关的LncRNA标志物的识别和验证作为新型胶质瘤预后模型
Kaihan Deng,Wei Zhao,Lin Dai et al.
Kaihan Deng et al.
A predictive model for long-term survival is needed, and mitochondrial dysfunction is a key feature of cancer metabolism, though its link to glioma is not well understood. The aim of this study was to identify the molecular characteristics ...
Thrombospondin-2 induces M2 macrophage polarization through fatty acid metabolism to drive lung adenocarcinoma proliferation [0.03%]
血小板生成素-2通过脂肪酸代谢诱导M2巨噬细胞极化以驱动肺腺癌增殖
Meiling Weng,Xiaoping Zhu
Meiling Weng
Tumor-associated macrophages play a critical role in regulating the progression of lung adenocarcinoma (LUAD). Platelet-derived protein thrombospondin-2 (THBS2) has been identified as a tumor marker and is known to be overexpressed in LUAD....
BTK inhibitors enhance NKG2D ligand expression by regulating IL-10/STAT3 pathway in activated non-GCB diffuse large B-cell lymphoma cells [0.03%]
BTK抑制剂通过调节激活的非GCB弥漫性大B细胞淋巴瘤细胞中的IL-10 / STAT3通路增强NKG2D配体的表达
Zhu-Xia Jia,Bi-Tao Xiao,Jin Li et al.
Zhu-Xia Jia et al.
The aim of this study is to explore the role of the IL-10/STAT3 pathway in the upregulation of natural killer group 2, member D (NKG2D) ligands (MICA and ULBP2) induced by Bruton's tyrosine kinase (BTK) inhibitors in non-germinal center B-c...