Investigating the causal association between liver condition and melanoma: evidence from the National Health and Nutrition Examination Survey and Mendelian randomization [0.03%]
基于美国国家健康和营养调查及孟德尔随机化研究证据探讨肝病与黑色素瘤间的因果关联
Bendian Song,Shitong Guo,Qiuchen Li et al.
Bendian Song et al.
This study aimed to investigate the association between liver condition and the risk of melanoma. We first conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004, involvi...
Spatial T lymphocyte infiltration into the primary melanoma tumor associates with survival [0.03%]
肿瘤空间T淋巴细胞浸润与黑色素瘤患者的生存期相关性分析
Sharon N Edmiston,Yi-Hsuan S Tsai,David L Corcoran et al.
Sharon N Edmiston et al.
Tumor infiltrating lymphocyte grade is a prognostic indicator for patients with cutaneous invasive primary melanoma and assigned one of three-levels (brisk, nonbrisk, or absent). We sought to develop objective, quantitative measures of T ly...
Scalp melanoma presents with greater Breslow thickness and higher metastatic burden: analysis of 105 Korean cutaneous head and neck melanoma patients [0.03%]
头皮黑色素瘤的Breslow厚度更大、转移负荷更高——105例韩国头颈部皮肤黑色素瘤患者的分析
Hong Euy Kim,Jinkyeong Kim,Dong Hoon Lee et al.
Hong Euy Kim et al.
Cutaneous head and neck melanoma (CHNM) accounts for a disproportionate share of melanoma-related mortality, yet the prognostic value of its precise anatomical site remains uncertain. We retrospectively reviewed 105 patients with CHNM diagn...
Hemophagocytic lymphohistiocytosis and posterior reversible encephalopathy syndrome during BRAF/MEK inhibitor therapy following immune checkpoint blockade in metastatic melanoma: a case report [0.03%]
抗PD-1治疗后使用BRAF/MEK抑制剂治疗黑色素瘤期间出现噬血细胞综合征和可逆性后部脑病综合征一例报告
Nina Bonkat,Jonas Hafele,Ivan Tancevski
Nina Bonkat
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially life-threatening hyperinflammatory syndrome characterized by uncontrolled immune activation and cytokine release. Secondary HLH has increasingly been reported in association...
A modern review of uveal melanoma: molecular insights, clinical management, and emerging therapies [0.03%]
眼脉络膜黑色素瘤的现代综述：分子见解、临床管理和新兴疗法
Bhanupriya Dhabhai,Abhijit Beura,Janvi Bhatankar et al.
Bhanupriya Dhabhai et al.
Uveal melanoma is the most frequent primary intraocular malignancy in adults and is characterized by an aggressive clinical course, high propensity for hepatic metastasis, and poor survival after metastatic progression. Improvements in ocul...
Endothelial protein C receptor expression as a marker of reduced metastatic risk in primary melanoma [0.03%]
内皮蛋白C受体表达作为原发性黑色素瘤降低转移风险的标记物
Takayuki Fusumae,Takeru Funakoshi,Ikuko Hirai et al.
Takayuki Fusumae et al.
Malignant melanoma has a strong propensity for early metastatic dissemination, yet conventional clinicopathological predictors such as Breslow thickness do not fully capture individual metastatic risk. The endothelial protein C receptor (EP...
Nectin-4 as predictive biomarker of immune-related adverse event subtypes in adjuvant anti-programmed-death-1 treatment of melanoma [0.03%]
nectin-4作为预测免疫检查点抑制剂治疗黑色素瘤术后复发的生物标志物及其介导的不良事件亚型的标记物研究
Sabrina Bruno,Andrew D Knight,Caroline J Layding et al.
Sabrina Bruno et al.
Immune checkpoint inhibitors have transformed melanoma management; however, immune-related adverse events (irAEs) remain a major source of morbidity. Soluble immunomodulatory proteins are established biomarkers of autoimmune reactivity but ...
Dissecting cellular heterogeneity across two ocular melanoma subtypes by single-cell RNA sequencing [0.03%]
通过单细胞RNA测序剖析两种眼黑色素瘤亚型的细胞异质性
Ziqi Gong,Fenghao Zhang,Yuxian Feng et al.
Ziqi Gong et al.
Ocular melanoma, the most common primary ocular malignancy in adults, is a rare subtype of melanoma characterized by high malignancy and poor prognosis. The aim of this study is to investigate the tumor cells and microenvironmental heteroge...
Wenhui Liu,Ya Xu,Yixin Yang et al.
Wenhui Liu et al.
To develop and deploy a publicly accessible online risk estimation tool for cutaneous melanoma that prioritizes high recall to minimize missed diagnoses, using real-world clinical photographs rather than dermoscopic images, and to bridge th...
The role of circulating tumor DNA in the management of melanoma: a literature review [0.03%]
循环肿瘤DNA在黑色素瘤管理中的作用：文献综述
Victoria Dos Santos,John Ochieng,Sahar Borna et al.
Victoria Dos Santos et al.
Circulating tumor DNA (ctDNA) is an emerging noninvasive biomarker in melanoma, yet its clinical relevance varies by disease stage and tumor biology. This literature review integrates mechanistic concepts with clinical evidence to clarify w...