Clinical development and evaluation of a VEGF-D assay in plasma from patients with metastatic colorectal cancer in the RAISE study [0.03%]
评估RAISE研究中转移性结直肠癌患者血浆VEGF-D检测的方法学开发和临床价值
Hiroya Taniguchi,Takayuki Yoshino,Kensei Yamaguchi et al.
Hiroya Taniguchi et al.
Background: Vascular endothelial growth factor (VEGF)-D was identified as a potential predictive biomarker for ramucirumab efficacy in second-line metastatic colorectal cancer using a research use only (RUO) assay. We des...
Randomized Controlled Trial
Current medical research and opinion. 2021 Oct;37(10):1769-1778. DOI:10.1080/03007995.2021.1940908 2021
Characteristics, treatment patterns, healthcare resource use, and costs among pediatric patients diagnosed with neurofibromatosis type 1 and plexiform neurofibromas: a retrospective database analysis of a medicaid population [0.03%]
一项基于医疗补助人口数据库的回顾性分析：神经纤维瘤病Ⅰ型伴丛状神经纤维瘤儿童患者的临床特征、治疗模式、医疗卫生资源利用及费用状况
Xiaoqin Yang,Kaushal Desai,Neha Agrawal et al.
Xiaoqin Yang et al.
Objectives: The objectives of this study were to describe the characteristics and initial treatment patterns, healthcare resource use (HCRU), and costs of patients newly diagnosed with neurofibromatosis type 1 (NF1)-relat...
A multicenter retrospective study on evaluation of predicative factors for positive biopsy of prostate cancer in real-world setting [0.03%]
一项关于真实世界阳性前列腺癌活检预测因素的多中心回顾性研究
Ben Xu,Gonghui Li,Chuize Kong et al.
Ben Xu et al.
Objective: This study aimed to evaluate the predictors for positive biopsy in prostate cancer (PCa) patients and develop a risk-stratification score model for positive biopsy rate in patients with prostate specific antige...
Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study [0.03%]
玻璃酸钠关节腔注射单次给药在膝骨关节炎患者中安全性研究：一项多中心前瞻性队列研究
Ki-Mo Jang,Yong-Geun Park,Won Kee Choi et al.
Ki-Mo Jang et al.
Objective: LBSA0103 is a recently developed high-molecular-weight, cross-linked, non-animal hyaluronic acid (HA). The safety of LBSA0103 has been investigated only in a limited number of patients, therefore this prospecti...
A varied approach to left ventricular assist device follow-up improves cost-effectiveness [0.03%]
多种方法进行左心室辅助装置术后随访可提高成本效益
Mustafa M Ahmed,Piaopiao Li,Lauren E Meece et al.
Mustafa M Ahmed et al.
Background: Left ventricular assist device (LVAD) implantation improves outcomes in advanced heart failure, however, the optimal frequency of outpatient assessments to improve cost-effectiveness and potentially avert read...
A medicine adoption model for assessing the expected effects of additional real-world evidence (RWE) at product launch [0.03%]
一种药品采纳模型：通过该模型可评估产品上市时额外的真实世界证据(RWE)的预期效果
Ravi Jandhyala
Ravi Jandhyala
Introduction: The optimal launch and adoption of novel medicines require effective navigation of the commercial and regulatory landscape, including three key gatekeeper groups: regulators, payors, and prescribers. Traditi...
Randomized Controlled Trial
Current medical research and opinion. 2021 Sep;37(9):1645-1655. DOI:10.1080/03007995.2021.1947218 2021
Current utilization patterns for long-acting insulin analogues including biosimilars among selected Asian countries and the implications for the future [0.03%]
selected亚洲国家的长效胰岛素类似物（包括生物仿制药）当前应用情况及其对未来的影响
Brian Godman,Mainul Haque,Santosh Kumar et al.
Brian Godman et al.
Introduction: Prevalence rates for diabetes mellitus continue to rise, which, coupled with increasing costs of complications, has appreciably increased expenditure in recent years. Poor glycaemic control including hypogly...
Development and validation of a claims-based model to identify patients at risk of chronic thromboembolic pulmonary hypertension following acute pulmonary embolism [0.03%]
基于索赔的模型的发展与验证：用于识别急性肺栓塞后慢性血栓栓塞性肺动脉高压高危患者的模型
Manreet K Kanwar,Michele Cole,Marjolaine Gauthier-Loiselle et al.
Manreet K Kanwar et al.
Objective: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease that often follows pulmonary embolism (PE). Screening for CTEPH is challenging, often delaying diagnosis and worsening prognosis. Predicti...
Increased risk of adverse cardiovascular events by strict glycemic control after percutaneous coronary intervention (HbA1c < 6.5% at 2 years) in type 2 diabetes mellitus combined with acute coronary syndrome: a 5-years follow-up study [0.03%]
2型糖尿病合并急性冠脉综合征患者经皮冠状动脉介入治疗后严格血糖控制（HBA1C
Tiangui Yang,Peng Fu,Jie Chen et al.
Tiangui Yang et al.
Objective: This study assessed the association between HbA1c level measured 2 years after percutaneous coronary intervention (PCI) and long-term clinical outcomes in type 2 diabetes mellitus combined with acute coronary s...
Observational Study
Current medical research and opinion. 2021 Sep;37(9):1517-1528. DOI:10.1080/03007995.2021.1947219 2021
Kidney, limb and ophthalmic complications, and death in patients with nonvalvular atrial fibrillation and type 2 diabetes prescribed rivaroxaban or warfarin: an electronic health record analysis [0.03%]
非瓣膜性房颤和2型糖尿病患者使用利伐沙班或华法林后的肾脏、肢体和眼部并发症以及死亡：一项电子健康记录分析
Olivia S Costa,Bridget O&#x;Donnell,Burcu Vardar et al.
Olivia S Costa et al.
Background: Patients with nonvalvular atrial fibrillation (NVAF) and type 2 diabetes are at risk of kidney, limb, and ophthalmic complications. We evaluated the rate of these complications and death in patients with NVAF ...