Real-world durability challenges with nAMD treatments and the potential promise of gene therapy [0.03%]
nAMD治疗的现实耐久性挑战以及基因疗法的潜在前景
Marion Munk,Frank G Holz,David Chow et al.
Marion Munk et al.
The introduction of anti-vascular endothelial growth factor (VEGF) therapies changed the treatment landscape for neovascular age-related macular degeneration (nAMD), slowing the progression of central vision loss. However, current anti-VEGF...
Cortisol's role in difficult-to-control type 2 diabetes: Insights from the CATALYST study-a plain language review [0.03%]
皮质醇在难治性2型糖尿病中的作用：来自CATALYST研究的见解——一篇通俗语言综述
Vanita R Aroda,Guillermo E Umpierrez,Steven V Edelman et al.
Vanita R Aroda et al.
Real-world evidence bridging clinical trials and routine clinical practice to improve patient care [0.03%]
真实世界证据连接临床试验和常规临床实践以改善患者护理
Wendy D&#x;Souza,Sonali Dalwadi,Emilie Mai Anderberg et al.
Wendy D&#x;Souza et al.
Real-world evidence (RWE) has emerged as an essential complement to randomized controlled trial data, providing insights into the effectiveness, safety, and tolerability of healthcare interventions in routine practice. The increasing digita...
From survival to healthy aging: reframing HIV care for older adults [0.03%]
从生存到健康老龄化：重新审视老年人的艾滋病毒护理
Chisom Ogochukwu Ezenwaji,Ngozi Asadu,Kosy Nneoma Ezenwaji et al.
Chisom Ogochukwu Ezenwaji et al.
Background: Effective antiretroviral therapy (ART), has transformed HIV into a chronic condition, enabling more people with HIV to reach older age. However, longevity has exposed a growing burden of multimorbidity, frailt...
Pathophysiological crosstalk between chronic obstructive pulmonary disease and type 2 diabetes mellitus: implications for SGLT2 inhibitor-based intervention [0.03%]
慢性阻塞性肺疾病与2型糖尿病的病理生理相互作用及钠-葡萄糖协同转运蛋白2抑制剂干预的启示
Rongshuang Yang,Weiping Fu
Rongshuang Yang
The intertwined global epidemics of chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) pose an increasing challenge in chronic disease management, constituting a clinically significant bidirectional threat. Thi...
Predicting the risk of venous thromboembolism events in older adults with rheumatoid arthritis after initiating targeted disease-modifying antirheumatic drugs: a comparison of the random survival forest and regularized cox regression models [0.03%]
生物信息学方法预测类风湿关节炎患者使用靶向抗风湿病药物治疗后静脉血栓事件的风险：随机生存森林模型和正则化Cox回归模型的比较研究
Yinan Huang,Shadi Bazzazzadehgan,Shishir Maharjan et al.
Yinan Huang et al.
Objectives: To develop a random survival forest (RSF) machine learning (ML) model for predicting venous thromboembolism (VTE) risk in rheumatoid arthritis (RA) patients initiating biological (b) or targeted synthetic (ts)...
Adverse effect profile of amphotericin B deoxycholate administered with a standardized infusion protocol in hematologic patients: a prospective study in a resource-limited setting [0.03%]
氨苯矾联合标准滴注方案治疗血液系统疾病的不良反应：资源匮乏条件下的前瞻性研究
Sreeraj Vasudevan,Govind R Patel,Pravas Mishra et al.
Sreeraj Vasudevan et al.
Background: Amphotericin B deoxycholate (AmBD), an effective and inexpensive antifungal agent, has significant adverse effects. Studies demonstrating the use of protective measures to prevent or reduce different adverse e...
Beyond maximally tolerated statins: PCSK9 inhibitors as a critical adjunct for cardiovascular risk reduction in peripheral artery disease-a systematic review and meta-analysis [0.03%]
外用最大可耐受他汀类药物：PCSK9抑制剂作为外周动脉疾病心血管风险降低的有力辅助-系统评价和meta分析
Dwi Ariyanti,Muhammad Isra Rafidin Rayyan,Hammam Arif Shabri et al.
Dwi Ariyanti et al.
Background: The role of PCSK9 inhibitors in PAD remains uncertain, despite their established benefits in atherosclerotic cardiovascular disease. This meta-analysis aimed to evaluate their effects on cardiovascular, functi...
Clinical outcomes with ciltacabtagene autoleucel among patients with relapsed/refractory multiple myeloma after four or more prior lines of therapy overall and among subgroups based on age, frailty, and CRAB symptoms [0.03%]
多次治疗后复发/难治多发性骨髓瘤患者的临床转归——采用cilta-cel治疗四线及以上治疗后的患者及其亚组分析（按年龄、虚弱程度和CRAB症状分层）
Doris K Hansen,Omar Alexis Castaneda Puglianini,Ariel Grajales-Cruz et al.
Doris K Hansen et al.
Background: Ciltacabtagene autoleucel (cilta-cel), a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy, has shown deep and durable responses in clinical trials for relapsed/refractory multiple my...
Bypassing the failing heart: can we save the kidneys in acute decompensated heart failure? [0.03%]
绕过衰竭的心脏：能否在急性心力衰竭时挽救肾脏？
Kevin A Wu,Grace Kim,Steven Wu
Kevin A Wu
Acute kidney injury (AKI) occurs in up to 40% of hospitalizations for acute decompensated heart failure (ADHF) and is associated with higher morbidity, longer hospital stays, and increased mortality. Despite its prevalence, current manageme...