Elevated Interleukin-8 in Spinocerebellar Ataxia Type 2: A Distinct Peripheral Immune Signature Unrelated To Disease Severity [0.03%]
脊髓小脑共济失调 II 型患者外周血中 IL-8 升高：与疾病严重程度无关的外周免疫特征
Yaimeé Vázquez-Mojena,Roberto Rodríguez-Labrada,Yanetsy Córdova-Rodríguez et al.
Yaimeé Vázquez-Mojena et al.
Growing experimental and clinical evidence demonstrates that immune activation influences Spinocerebellar Ataxia type 2 (SCA2) phenotype, yet the specific role of proinflammatory cytokines remains unexplored. This stuyd aims to measure peri...
Deletion of the Voltage-Gated Calcium Channel Gene, CaV1.3, Reduces Purkinje Cell Dendritic Complexity Without Altering Cerebellar-Mediated Eyeblink Conditioning [0.03%]
电压门控钙通道基因CaV1.3的缺失减少了浦肯野细胞树突复杂性而不改变眼睑条件反射行为
Annette Klomp,Martha Pace,Jacqueline Mehr et al.
Annette Klomp et al.
Genetic variation in CACNA1D, the gene that encodes the pore-forming subunit of the L-type calcium channel CaV1.3, has been associated with increased risk for neuropsychiatric disorders that display abnormalities in cerebellar structures. W...
Cognitive Deficits in Spinocerebellar Ataxia Type 2: A Comparative Analysis of Pre-ataxic and Ataxic Stages [0.03%]
脊髓小脑共济失调2型的认知障碍：前共济失调期和共济失调期的比较分析
Renata Barreto Tenorio,Andressa Aline Vieira,Walter Oleschko Arruda et al.
Renata Barreto Tenorio et al.
Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disorder characterized by cerebellar motor symptoms. The extent and timing of cognitive involvement, particularly in pre-ataxic carriers, remain unclear. To assess cognitive perfor...
Comparative Study
Cerebellum (London, England). 2025 Oct 10;24(6):163. DOI:10.1007/s12311-025-01918-8 2025
Cerebellar Hemispheric Contribution to the Dynamics of Visuomotor Learning during Interlimb Coordination: Insights from an rTMS Study [0.03%]
重复经颅磁刺激研究提示小脑半球在跨侧上肢协调运动视觉运动学习中的作用
Akiyoshi Matsugi,Keisuke Tani,Satoru Nishishita et al.
Akiyoshi Matsugi et al.
This study investigated the effects of repetitive transcranial magnetic stimulation (rTMS) over the right cerebellar hemisphere on visuomotor adaptation and interlimb coordination learning. Specifically, we examined the impact of cerebellar...
Enhancing Balance Control in Aging Through Cerebellar Theta-Burst Stimulation [0.03%]
通过小脑θ节律刺激改善老龄化平衡控制能力
Ashwini Sansare,Madison Weinrich,Jessica A Bernard et al.
Ashwini Sansare et al.
The cerebellum undergoes significant age-related changes linked to poor balance in older adults. Although multi-session cerebellar iTBS combined with rehabilitation has been used in some clinical populations, its isolated effects in communi...
Randomized Controlled Trial
Cerebellum (London, England). 2025 Oct 8;24(6):161. DOI:10.1007/s12311-025-01915-x 2025
Lateral Cerebellar Theta Burst Stimulation Can Modulate Default Mode Network Connectivity in Autistic Adults [0.03%]
成人自闭症患者侧小脑经颅 theta 爆破刺激可调节默认模式网络连接性
Hsing-Chang Ni,Heng Chien,Chun-Hung Yeh et al.
Hsing-Chang Ni et al.
Developing effective neuromodulation strategies for core autistic symptoms remains a critical need. The lateral cerebellum, implicated in socio-cognitive functions often affected in autism, represents a promising target for repetitive trans...
Novel SACS Variants not Recorded in ClinVar Identified in a Chinese Patient with Late-Onset Hereditary Neuropathy: a Case Report and Literature Review [0.03%]
中国晚发性遗传性神经病患者中鉴定出的新型SACS变异：病例报告和文献回顾
Meiyuan Chen,Xiaochuan Wang,Xiaojun Ye et al.
Meiyuan Chen et al.
Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is a rare neurodegenerative disorder due to mutations in the SACS gene. While the typical phenotype is characterized by cerebellar ataxia, spasticity, and peripheral neuropa...
Article Title: Impact of Dysphagia on Quality of Life in Machado-Joseph Disease [0.03%]
马查多-约瑟夫病患者吞咽困难对其生活质量的影响
Joana Paz Mota,Inês Tello Rodrigues,Ana Filipa Ferreira et al.
Joana Paz Mota et al.
Dysphagia is a frequent symptom of spinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD), being associated with alterations in nutritional intake and hydration, as well as an increased risk of aspiration pneumonia. This study ai...
Longitudinal Study and Characterization of Gait Impairment in a Mouse Model of SCA1 [0.03%]
用于研究脊髓小脑萎缩症1型纵向步态障碍特征的小鼠模型
Siddhartha Maharjan,Eliyahu Kochman,Tatiana Gervase et al.
Siddhartha Maharjan et al.
Spinocerebellar ataxia 1 (SCA1) is a rare autosomal dominant neurodegenerative disease characterized by impaired gait, coordination, and balance. SCA1 results from an expanded CAG repeat in the Atxn1 gene, inducing protein aggregation and u...
Submovements Derived from Wearable Sensors Capture Ataxia Severity and Differ Across Motor Tasks and Directions of Motion [0.03%]
源自可穿戴传感器的次级运动捕捉了共济失调的严重程度并在不同的运动任务和运动方向之间有所不同
Siddharth Patel,Brandon Oubre,Christopher D Stephen et al.
Siddharth Patel et al.
Digital measures derived from wearable sensors are a promising approach for assessing motor impairment in clinical trials. Submovements, which are velocity curves extracted from time series data, have been successful in characterizing impai...