INTERVERTEBRAL DISC DEGENERATION INSTIGATES VERTEBRAL ENDPLATE REMODELING AND FACET JOINT PATHOLOGY IN A LARGE ANIMAL MODEL [0.03%]
椎间盘退变诱发大型动物模型椎体终板重塑及小关节病理性改变
S E Gullbrand,B S Orozco,M Fainor et al.
S E Gullbrand et al.
Although the intervertebral discs are the most studied region of the spinal motion segment with respect to their degeneration and contributions to back pain, it is becoming increasingly evident that degeneration of adjacent structures inclu...
Ginny Ching-Yun Hsu
Ginny Ching-Yun Hsu
Temporomandibular joint osteoarthritis (TMJ OA) occurs in 8 to 16 % of the population. Currently available animal models do not faithfully simulate the native disease progression of TMJ OA. The initiation of TMJ OA requires both local traum...
DESIGNER FAT CELLS: ADIPOGENIC DIFFERENTIATION OF CRISPR-CAS9 GENOME-ENGINEERED INDUCED PLURIPOTENT STEM CELLS [0.03%]
经CRISPR-Cas9基因编辑的诱导多能干细胞向脂肪细胞分化：设计感的脂肪细胞
E V Ely,A T Kapinski,S G Paradi et al.
E V Ely et al.
Adipose tissue is an active endocrine organ that can signal bidirectionally to many tissues and organ systems in the body. With obesity, adipose tissue can serve as a source of low-level inflammation that contributes to various co-morbiditi...
Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects [0.03%]
一种用于治疗大型负重关节软骨缺损的生物可吸收复合支架的开发（具有合适的机械性能）
M Joyce,T Hodgkinson,M Lemoine et al.
M Joyce et al.
Extracellular matrix (ECM) biomaterials have shown promise for treating small artucular-joint defetcs. However, ECM-based biomaterials generally lack appropriate mechanical properties to support physiological loads and are prone to delamina...
Understanding the effects of mesenchymal stromal cell therapy for treating osteoarthritis using an in vitro co-culture model [0.03%]
利用体外共培养模型理解间充质基质细胞治疗骨关节炎的效果
V Shang,J Li,C B Little et al.
V Shang et al.
Osteoarthritis (OA) is a leading cause of chronic pain and disability, for which there is no cure. Mesenchymal stromal cells (MSCs) have been used in clinical trials for treating OA due to their unique ability to generate paracrine anti-inf...
Disrupting mechanical homeostasis promotes matrix metalloproteinase-13 mediated processing of neuron glial antigen 2 in mandibular condylar cartilage [0.03%]
机械稳态紊乱促进下颌髁软骨中基质金属蛋白酶-13介导的神经胶质前体蛋白-2加工反应
M Bagheri Varzaneh,Y Zhao,J Rozynek et al.
M Bagheri Varzaneh et al.
Post-traumatic osteoarthritis in the temporomandibular joint (TMJ OA) is associated dysfunctional cellmatrix mediated signalling resulting from changes in the pericellular microenvironment after injury. Matrix metalloproteinase (MMP)-13 is ...
Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation [0.03%]
离体椎间盘培养：退变诱导方法及其临床转化意义
E Salzer,T C Schmitz,V Hm Mouser et al.
E Salzer et al.
Because low back pain is frequently a result of intervertebral disc degeneration (IVDD), strategies to regenerate or repair the IVD are currently being investigated. Often, ex vivo disc cultures of non-human IVD organs or tissue explants ar...
Three-dimensional culture model to study the biology of vacuolated notochordal cells from mouse nucleus pulposus explants [0.03%]
小鼠椎间盘髓核组织块中囊性腔细胞的三维培养及其生物学特性研究
L Paillat,K Coutant,M Dutilleul et al.
L Paillat et al.
Intervertebral disc degeneration (IDD) involves cellular changes in the nucleus pulposus (NP) characterised by a decline of the large vacuolated notochordal cells (vNCs) and a rise of smaller vacuole-free mature chondrocyte-like NP cells. A...
Microstructural adaptations of the subchondral bone are related to the mechanical axis deviation in end stage varus oa knees [0.03%]
晚期内翻膝骨关节炎的股骨远端皮质骨微结构变化与机械轴偏移的关系研究
W Colyn,F Azari,J Bellemans et al.
W Colyn et al.
Recent studies highlighted the crucial contribution of subchondral bone to OA development. Yet, only limited data have been reported on the relation between alteration to cartilage morphology, structural properties of the subchondral bone p...
Mandibular condylar process remodeling in rats with different bite-altering devices [0.03%]
不同矫正装置改变咬合对大鼠下颌关节髁突改建的影响
W Li,S Trbojevic,J B Pineda-Farias et al.
W Li et al.
The objective was to compare different dental splint models and materials for inducing abnormal loading on the gross morphology and histological appearance of the mandibular condylar processes of Sprague Dawley rats. Three different types o...