Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project [0.03%]
五羟色胺转运蛋白基因多态性与生活事件的交互作用预测GENDEP项目中抗抑郁药物的疗效
R Keers,R Uher,P Huezo-Diaz et al.
R Keers et al.
There is substantial inter-individual variation in response to antidepressants, and genetic variation may, in part, explain these differences. For example, there is evidence to suggest that variation in the serotonin transporter gene (SLC6A...
Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia [0.03%]
多药耐药相关蛋白1和5-羟色胺2C受体基因多态性与女性精神分裂症患者抗精神病药物代谢障碍关联研究
M R Kuzman,V Medved,N Bozina et al.
M R Kuzman et al.
The objective of this study was to determine the association of 5-HT2C (serotonin 2C receptor) and MDR1 (multidrug resistant protein) genetic polymorphisms and antipsychotic-induced metabolic abnormalities among female patients with DSM IV ...
BDNF Val66Met genotype and 6-month remission rates in late-life depression [0.03%]
晚年的抑郁症患者中BDNF Val66Met基因型与6个月的缓解率之间的关系
W D Taylor,D R McQuoid,A Ashley-Koch et al.
W D Taylor et al.
Although not observed in younger adult cohorts, in older individuals the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with major depressive disorder (MDD) risk. It is further associated with subjective social...
Single nucleotide polymorphisms in genes that are associated with a modified response to statin therapy: the Rotterdam Study [0.03%]
与斯他汀类他汀耐药相关基因的单核苷酸多态性：从鹿特丹研究中获得的证据
C E de Keyser,M Eijgelsheim,A Hofman et al.
C E de Keyser et al.
The objective of this study was to investigate whether common variation in genes involved in lipid metabolism modify the effect of statins on serum total cholesterol concentration. Statin users were identified in the Rotterdam Study, a pros...
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity [0.03%]
羧酸酯酶基因多态性与异烟肼致肝毒性的关联研究
S Yamada,K Richardson,M Tang et al.
S Yamada et al.
Treatment of latent tuberculosis infection (LTBI) generally includes isoniazid (INH), a drug that can cause serious hepatotoxicity. Carboxylesterases (CES) are important in the metabolism of a variety of substrates, including xenobiotics. W...
Genetic modulation of the Let-7 microRNA binding to KRAS 3'-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan [0.03%]
Let-7微RNA与KRAS 3'非翻译区的结合力遗传调节对接受西妥昔单抗-伊立替康解救治疗的转移性结直肠癌患者的生存影响
F Graziano,E Canestrari,F Loupakis et al.
F Graziano et al.
There is increasing evidence that the Let-7 microRNA (miRNA) exerts an effect as a tumor suppressor by targeting the KRAS mRNA. The Let-7 complementary site (LCS6) T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding. We ana...
Clinical Trial
The pharmacogenomics journal. 2010 Oct;10(5):458-64. DOI:10.1038/tpj.2010.9 2010
In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor [0.03%]
基于计算机和体外的药理遗传学：aldo氧化酶快速代谢p38激酶抑制剂
X Zhang,H-H Liu,P Weller et al.
X Zhang et al.
The clinical development of a candidate p38 kinase inhibitor was terminated because of its unexpectedly rapid clearance in human subjects. Its short half-life and metabolic profile in human beings were vastly different from that in rats, do...
Clinical Trial
The pharmacogenomics journal. 2011 Feb;11(1):15-24. DOI:10.1038/tpj.2010.8 2011
Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer [0.03%]
用于预测患者在接受伊立替康和5-氟尿嘧啶治疗的晚期结直肠癌时出现毒性和反应的模型
B Glimelius,H Garmo,A Berglund et al.
B Glimelius et al.
Irinotecan and 5-fluorouracil (5-FU) are used to treat metastatic colorectal cancer. Irinotecan's active metabolite is inactivated by UDP-glucuronosyltransferase 1A1 (UGT1A1), which is deficient in Gilbert's syndrome. Irinotecan and metabol...
Randomized Controlled Trial
The pharmacogenomics journal. 2011 Feb;11(1):61-71. DOI:10.1038/tpj.2010.10 2011
SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance [0.03%]
ROS代谢和信号转导基因多态性与多西他赛清除率相关性研究
H Edvardsen,P F Brunsvig,H Solvang et al.
H Edvardsen et al.
The dose of docetaxel is currently calculated based on body surface area and does not reflect the pharmacokinetic, metabolic potential or genetic background of the patients. The influence of genetic variation on the clearance of docetaxel w...
Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines [0.03%]
药理表型的可遗传和非遗传因素在淋巴母细胞系中的变量作用
A L Stark,W Zhang,S Mi et al.
A L Stark et al.
Publicly available genetic and expression data on lymphoblastoid cell lines (LCLs) make them a unique resource for understanding the genetic underpinnings of pharmacological outcomes and disease. LCLs have been used for pharmacogenomic disc...