A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs [0.03%]
一个新的Cdh23基因小鼠突变体模型早期出现听力损失，有助于评估耳保护药物的效果
F Han,H Yu,C Tian et al.
F Han et al.
We report a novel mutation (erlong, erl) of the cadherin 23 (Cdh23) gene in a mouse model for DFNB12 characterized by progressive hearing loss beginning from postnatal day 27 (P27). Genetic and sequencing analysis revealed a 208 T >C transi...
Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease [0.03%]
载脂蛋白E和丁酰胆碱酯酶基因多态性对阿尔茨海默病不同阶段患者乙酰胆碱酯酶抑制剂疗效的影响
C E Patterson,S A Todd,A P Passmore
C E Patterson
Factors that influence response to drug treatment are of increasing importance. We report an analysis of genetic factors affecting response to cholinesterase inhibitor therapy in 165 subjects with Alzheimer's disease (AD). The presence of a...
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer [0.03%]
一种大规模候选基因方法确定SOD2和IL13中的SNPs可作为预测直肠癌新辅助放化疗疗效的标志物
A Ho-Pun-Cheung,E Assenat,C Bascoul-Mollevi et al.
A Ho-Pun-Cheung et al.
Neoadjuvant radiochemotherapy followed by total mesorectal excision is now the standard treatment for locally advanced rectal cancer. However, tumor response to chemoradiation varies widely among individuals and cannot be determined before ...
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate [0.03%]
酒精依赖、复发风险和acamprosate治疗反应与心房利钠肽转录因子GATA4的关系
F Kiefer,S H Witt,J Frank et al.
F Kiefer et al.
In alcoholism, both relapse to alcohol drinking and treatment response are suggested to be genetically modulated. This study set out to determine whether the top 15 single nucleotide polymorphisms (SNPs) of a recent genome-wide association ...
Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan [0.03%]
原发性微小RNA多态性变异在5-氟尿嘧啶和伊立替康治疗转移性结直肠癌患者中的作用
V Boni,R Zarate,J C Villa et al.
V Boni et al.
MicroRNAs are non-coding RNAs that can block mRNA translation and influence mRNA stability. Recent evidence indicates that miRNA variations can affect drug resistance, efficacy, and metabolism, opening new avenues of pharmacogenomics resear...
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions [0.03%]
基于基因型的有机阳离子转运体OCT1抑制剂的作用效应及代谢性磷酸化物相互作用的预测
G Ahlin,L Chen,L Lazorova et al.
G Ahlin et al.
Common genetic variants of the liver-specific human organic cation transporter 1 (OCT1; SLC22A1) have reduced transport capacity for substrates such as the antidiabetic drug metformin. The effect of the reduced OCT1 function on drug interac...
Gender-related survival differences associated with polymorphic variants of estrogen receptor-β (ERβ) in patients with metastatic colon cancer [0.03%]
与转移性结直肠癌患者雌激素受体-β多态性变异相关的性别差异生存分析
O A Press,W Zhang,M A Gordon et al.
O A Press et al.
Estrogen replacement therapy in women has shown a protective effect on the development of colonic carcinomas. Gender-related differences in the development of colonic carcinomas have also been reported. Estrogen receptor-β (ERβ) is expres...
High-efficiency genotype analysis from formalin-fixed, paraffin-embedded tumor tissues [0.03%]
高效分析甲醛固定石蜡包埋的肿瘤组织基因型
M J Sikora,J N Thibert,J Salter et al.
M J Sikora et al.
Single-nucleotide polymorphisms (SNPs) can be assayed using DNA isolated from archival formalin-fixed, paraffin-embedded (FFPE) samples, making retrospective pharmacogenetic studies possible. In this study, we describe methods that signific...
Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors [0.03%]
多态人前列腺素H合成酶-2蛋白及其与环氧化酶底物和抑制剂的相互作用
W Liu,E M Poole,C M Ulrich et al.
W Liu et al.
The cyclooxygenase (COX) activity of prostaglandin H synthase-2 (PGHS-2) is implicated in colorectal cancer and is targeted by nonsteroidal anti-inflammatory drugs (NSAIDs) and dietary n-3 fatty acids. We used purified, recombinant proteins...
Changes in the gene expression profile of gastric cancer cells in response to ibuprofen: a gene pathway analysis [0.03%]
基因路径分析指导的吲哚美辛诱导的胃癌细胞系中的基因表达谱变化研究
P Bonelli,F M Tuccillo,R Calemma et al.
P Bonelli et al.
Nonsteroidal anti-inflammatory drugs possess antiproliferative activities that can affect cancer cells. The aim of this study was to examine the antiproliferative effects of ibuprofen on the MKN-45 cell line. Cells were treated with ibuprof...