Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy [0.03%]
患者遗传谱预测接受新辅助放化疗的直肠癌患者的肿瘤反应
E Cecchin,M Agostini,S Pucciarelli et al.
E Cecchin et al.
The aim of the study was the identification of a pharmacogenetic profile predictive of the tumor regression grade (TRG), considered as tumor response parameter, after neo-adjuvant treatment in rectal cancer patients. A total of 238 rectal c...
Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples [0.03%]
评估基因型不一致性的来源及其对包含HapMap样本的全基因组关联研究的影响
H Hong,L Shi,Z Su et al.
H Hong et al.
The discordance in results of independent genome-wide association studies (GWAS) indicates the potential for Type I and Type II errors. We assessed the repeatibility of current Affymetrix technologies that support GWAS. Reasonable reproduci...
A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion [0.03%]
低风险ZnT-8等位基因（W325）可预防环孢素A诱导的胰岛素分泌障碍及移植物糖尿病
I Kim,E S Kang,Y S Yim et al.
I Kim et al.
SLC30A8 encodes the β-cell-specific zinc transporter-8 (ZnT-8) expressed in insulin secretory granules. The single-nucleotide polymorphism rs13266634 of SLC30A8 is associated with susceptibility to post-transplantation diabetes mellitus (P...
A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants [0.03%]
一种GTP环化酶I反馈调节基因多态性改变转录活性并可能影响选择性5-羟色胺再摄取抑制剂抗抑郁药的疗效
P C McHugh,P R Joyce,X Deng et al.
P C McHugh et al.
Tetrahydrobiopterin (BH(4)) is an essential cofactor for synthesis of many neurotransmitters including serotonin. In serotonergic neurons, BH(4) is tightly regulated by GTP-cyclohydrolase I feedback regulator (GFRP). Given the pivotal role ...
Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function [0.03%]
ABCC2基因型对转录和转录后基因调控及功能的影响
S Laechelt,E Turrini,A Ruehmkorf et al.
S Laechelt et al.
ABCC2 (MRP2) is an important export pump, expressed at tissue barriers. The genetic variants -24C>T, 1249G>A and 3972C>T are leading to inter-individual differences of bioavailability of various endogenous and exogenous compounds. Consideri...
Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis [0.03%]
氯吡格雷患者的细胞色素P450 2C19*2多态性与心血管事件复发风险的meta分析研究
F Sofi,B Giusti,R Marcucci et al.
F Sofi et al.
Several polymorphisms in genes that encode platelet components (receptors or enzymes), or cytochrome P450 enzyme isoforms, involved in clopidogrel metabolism, have been proposed as possible mechanisms for nonresponsiveness to clopidogrel. A...
Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial [0.03%]
基于细胞色素P450 2D6、CYP2C19和SULT1A1基因型的他莫昔芬在中国人预防性试验中的疗效研究
D Serrano,M Lazzeroni,C-F Zambon et al.
D Serrano et al.
The role of pharmacogenomics and tamoxifen was investigated by analyzing several polymorphisms of cytochrome P450 and SULT1A1 gene in a nested case control study from the Italian Tamoxifen Prevention Trial. This study included 182 Caucasian...
Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians [0.03%]
性别和CYP3A5基因型影响总CYP3A活性：埃塞俄比亚人高的CYP3A活性及独特的CYP3A5变异等位基因分布
E Gebeyehu,E Engidawork,A Bijnsdorp et al.
E Gebeyehu et al.
The objectives of the this study were to assess the influence of CYP3A5 genotype and sex on the variability in total CYP3A activity and to compare 4β-hydroxycholesterol and omeprazole sulfoxidation as phenotypic markers for CYP3A activity ...
Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions [0.03%]
为什么青年女性会吸烟？第六部分：注意力的控制研究：尼古丁与表型的相互作用
A Rigbi,A Yakir,K Sarner-Kanyas et al.
A Rigbi et al.
In prior studies we found that young, female smokers manifest poorer performance than non-smokers on attention-related tasks and that these findings can be moderated by variation in nicotinic acetylcholine receptor (nAChR) genes. We predict...
Randomized Controlled Trial
The pharmacogenomics journal. 2011 Feb;11(1):45-52. DOI:10.1038/tpj.2010.15 2011
Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity [0.03%]
细胞色素P450 2C8和3A5的多态性与紫杉醇神经毒性有关
S Leskelä,C Jara,L J Leandro-García et al.
S Leskelä et al.
Neurotoxicity is one of the most relevant dose-limiting toxicities of the anticancer drug paclitaxel. It exhibits substantial interindividual variability of unknown molecular basis, and represents one of the major challenges for the improve...